Evidence map›Paper›PMID 26839569›Full record

ReviewStem cells international2016

Endothelial Progenitor Cells for Diagnosis and Prognosis in Cardiovascular Disease.

Caterina Oriana Aragona, Egidio Imbalzano, Federica Mamone, Valentina Cairo, Alberto Lo Gullo, Angela D'Ascola, Maria Adriana Sardo, Michele Scuruchi, Giorgio Basile, Antonino Saitta and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Stem cells international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 66 citations in OpenAlex.

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  12. Endothelial progenitor cells predict vascular damage progression in naive hypertensive patients according to sex.Hypertension research : official journal of the Japanese Society of Hypertension · 2021
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  19. TERT assists GDF11 to rejuvenate senescent VEGFR2Laboratory investigation; a journal of technical methods and pathology · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Caterina Oriana AragonaDepartment of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, Gazzi, 98125 Messina, Italy.ORCID 0000-0002-1314-6602
Egidio ImbalzanoDepartment of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, Gazzi, 98125 Messina, Italy.ORCID 0000-0003-2656-5467
Federica MamoneDepartment of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, Gazzi, 98125 Messina, Italy.ORCID 0000-0003-2959-7472
Valentina CairoDepartment of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, Gazzi, 98125 Messina, Italy.
Alberto Lo GulloDepartment of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, Gazzi, 98125 Messina, Italy.ORCID 0000-0003-4383-0314
Angela D'AscolaDepartment of Biochemical, Physiological and Nutritional Sciences, University of Messina, Via Consolare Valeria, Gazzi, 98125 Messina, Italy.
Maria Adriana SardoDepartment of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, Gazzi, 98125 Messina, Italy.ORCID 0000-0003-2872-2542
Michele ScuruchiDepartment of Biochemical, Physiological and Nutritional Sciences, University of Messina, Via Consolare Valeria, Gazzi, 98125 Messina, Italy.
Giorgio BasileDepartment of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, Gazzi, 98125 Messina, Italy.
Antonino SaittaDepartment of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, Gazzi, 98125 Messina, Italy.ORCID 0000-0002-2577-5676
Giuseppe MandraffinoDepartment of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, Gazzi, 98125 Messina, Italy.
University of Messina · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective. To identify, evaluate, and synthesize evidence on the predictive power of circulating endothelial progenitor cells (EPCs) in cardiovascular disease, through a systematic review of quantitative studies. Data Sources. MEDLINE was searched using keywords related to "endothelial progenitor cells" and "endothelium" and, for the different categories, respectively, "smoking"; "blood pressure"; "diabetes mellitus" or "insulin resistance"; "dyslipidemia"; "aging" or "elderly"; "angina pectoris" or "myocardial infarction"; "stroke" or "cerebrovascular disease"; "homocysteine"; "C-reactive protein"; "vitamin D". Study Selection. Database hits were evaluated against explicit inclusion criteria. From 927 database hits, 43 quantitative studies were included. Data Syntheses. EPC count has been suggested for cardiovascular risk estimation in the clinical practice, since it is currently accepted that EPCs can work as proangiogenic support cells, maintaining their importance as regenerative/reparative potential, and also as prognostic markers. Conclusions. EPCs showed an important role in identifying cardiovascular risk conditions, and to suggest their evaluation as predictor of outcomes appears to be reasonable in different defined clinical settings. Due to their capability of proliferation, circulation, and the development of functional progeny, great interest has been directed to therapeutic use of progenitor cells in atherosclerotic diseases. This trial is registered with registration number: Prospero CRD42015023717.

Identifiers

PMID26839569
PMCPMC4709789
OpenAlexW2255090278

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.