Evidence map›Paper›PMID 26839563›Full record

ArticleStem cells international2016

Comparison of Signaling Pathways Gene Expression in CD34(-) Umbilical Cord Blood and Bone Marrow Stem Cells.

Rafał Stojko, Monika Bojdys-Szyndlar, Agnieszka Drosdzol-Cop, Andrzej Madej, Krzysztof Wilk

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. The role of the CCN family of proteins in blood cancers.Journal of cell communication and signaling · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Rafał StojkoSchool of Health Sciences in Katowice, Chair of Woman's Health, Medical University of Silesia, Ulicy Medyków 12, 40-752 Katowice, Poland; Department of Obstetrics and Gynecology, The Boni Fratres Catoviensis Hospital, Ulica Księdza Leopolda Markiefki 87, 40-211 Katowice, Poland.
Monika Bojdys-SzyndlarDepartment of Obstetrics and Gynecology, The Boni Fratres Catoviensis Hospital, Ulica Księdza Leopolda Markiefki 87, 40-211 Katowice, Poland.
Agnieszka Drosdzol-CopSchool of Health Sciences in Katowice, Chair of Woman's Health, Medical University of Silesia, Ulicy Medyków 12, 40-752 Katowice, Poland; Department of Obstetrics and Gynecology, The Boni Fratres Catoviensis Hospital, Ulica Księdza Leopolda Markiefki 87, 40-211 Katowice, Poland.
Andrzej MadejSchool of Health Sciences in Katowice, Chair of Woman's Health, Medical University of Silesia, Ulicy Medyków 12, 40-752 Katowice, Poland.
Krzysztof WilkDepartment of Obstetrics and Gynecology, The Boni Fratres Catoviensis Hospital, Ulica Księdza Leopolda Markiefki 87, 40-211 Katowice, Poland.
General Hospital of Attica · GRMedical University of Silesia · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the study was to compare the biological activity of the total pool of genes in CD34(-) umbilical cord blood and bone marrow stem cells and to search for the differences in signaling pathway gene expression responsible for the biological processes. The introductory analysis revealed a big similarity of gene expression among stem cells. When analyzing GO terms for biological processes, we observed an increased activity of JAK-STAT signaling pathway, calcium-mediated, cytokine-mediated, integrin-mediated signaling pathway, and MAPK in a cluster of upregulating genes in CD34(-) umbilical cord blood stem cells. At the same time, we observed a decreased activity of BMP signaling pathways, TGF-beta pathway, and VEGF receptor signaling pathway in a cluster of downregulating genes in CD34(-) umbilical cord blood stem cells. In accordance with KEGG classification, the cytokine-cytokine receptor interaction, toll-like receptor signaling pathway, and JAK-STAT signaling pathway are overrepresented in CD34(-) umbilical cord blood stem cells. A similar gene expression in both CD34(-) UCB and BM stem cells was characteristic for such biological processes as cell division, cell cycle gene expression, mitosis, telomere maintenance with telomerase, RNA and DNA treatment processes during cell division, and similar genes activity of Notch and Wnt signaling pathways.

Identifiers

PMID26839563
PMCPMC4709787
OpenAlexW1941678176

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.