ReviewStem cells international2016
Engineering Tendon: Scaffolds, Bioreactors, and Models of Regeneration.
Review in Stem cells international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review.Advanced healthcare materials · 2026Review
- Biomimetic Constructs for Achilles Tendon Regeneration and their Translation to Human Medicine.Tissue engineering and regenerative medicine · 2026Review
- Historical evolution, hotspots, and trends in tendon tissue engineering: A bibliometric analysis.Regenerative therapy · 2025Article
- Article
- Engineered Decellularized Tendon Matrix Putty Preserves Native Tendon Bioactivity to Promote Cell Proliferation and Enthesis Repair.Journal of tissue engineering and regenerative medicine · 2023Article
- Biomechanical Forces in the Tissue Engineering and Regeneration of Shoulder, Hip, Knee, and Ankle Joints.Journal of biotechnology and biomedicine · 2023Article
- An overview of the material science and knowledge of nanomedicine, bioscaffolds, and tissue engineering for tendon restoration.Frontiers in bioengineering and biotechnology · 2023Review
- Automated Assessment of Cell Infiltration and Removal in Decellularized Scaffolds - Experimental Study in Rabbits.Revista brasileira de ortopedia · 2022Article
- Humanoid robots to mechanically stress human cells grown in soft bioreactors.Communications engineering · 2022Article
- Mesenchymal Stromal Cells Adapt to Chronic Tendon Disease Environment with an Initial Reduction in Matrix Remodeling.International journal of molecular sciences · 2021Article
- Fibrous Systems as Potential Solutions for Tendon and Ligament Repair, Healing, and Regeneration.Advanced healthcare materials · 2021Review
- Tendon Tissue Repair in Prospective of Drug Delivery, Regenerative Medicines, and Innovative Bioscaffolds.Stem cells international · 2021Review
- The Lack of a Representative Tendinopathy Model Hampers Fundamental Mesenchymal Stem Cell Research.Frontiers in cell and developmental biology · 2021Review
- A brief history of tendon and ligament bioreactors: Impact and future prospects.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Review
- Review
- Independent, Controllable Stretch-Perfusion Bioreactor Chambers to Functionalize Cell-Seeded Decellularized Tendons.Annals of biomedical engineering · 2020Article
- Design of a Bioreactor to Assess the Effect of Passive Joint Loading in a Live Chick EmbryoTissue engineering. Part C, Methods · 2019Article
- Orthopaedic regenerative tissue engineering en route to the holy grail: disequilibrium between the demand and the supply in the operating room.Journal of experimental orthopaedics · 2018Review
- Boosting tendon repair: interplay of cells, growth factors and scaffold-free and gel-based carriers.Journal of experimental orthopaedics · 2018Review
- Combination of biochemical and mechanical cues for tendon tissue engineering.Journal of cellular and molecular medicine · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tendons bridge muscle and bone, translating forces to the skeleton and increasing the safety and efficiency of locomotion. When tendons fail or degenerate, there are no effective pharmacological interventions. The lack of available options to treat damaged tendons has created a need to better understand and improve the repair process, particularly when suitable autologous donor tissue is unavailable for transplantation. Cells within tendon dynamically react to loading conditions and undergo phenotypic changes in response to mechanobiological stimuli. Tenocytes respond to ultrastructural topography and mechanical deformation via a complex set of behaviors involving force-sensitive membrane receptor activity, changes in cytoskeletal contractility, and transcriptional regulation. Effective ex vivo model systems are needed to emulate the native environment of a tissue and to translate cell-matrix forces with high fidelity. While early bioreactor designs have greatly expanded our knowledge of mechanotransduction, traditional scaffolds do not fully model the topography, composition, and mechanical properties of native tendon. Decellularized tendon is an ideal scaffold for cultivating replacement tissue and modeling tendon regeneration. Decellularized tendon scaffolds (DTS) possess high clinical relevance, faithfully translate forces to the cellular scale, and have bulk material properties that match natural tissue. This review summarizes progress in tendon tissue engineering, with a focus on DTS and bioreactor systems.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.