ReviewStem cells international2016
Metaboloepigenetic Regulation of Pluripotent Stem Cells.
Review in Stem cells international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 62 citations in OpenAlex.
- Priming of human iPSCs with doxorubicin causes genome-wide transcriptional reprogramming and functional impairments in iPSC-derived cardiomyocytes.NPJ Regenerative medicine · 2026Article
- Blastocyst-Derived Lactate as a Key Facilitator of Implantation.Biomolecules · 2025Review
- Epigenetic regulation and factors that influence the effect of iPSCs-derived neural stem/progenitor cells (NS/PCs) in the treatment of spinal cord injury.Clinical epigenetics · 2024Review
- β-hydroxybutyrate reduces blastocyst viability via trophectoderm-mediated metabolic aberrations in mice.Human reproduction (Oxford, England) · 2022Article
- Integrating spatial transcriptomics with single-cell transcriptomics reveals a spatiotemporal gene landscape of the human developing kidney.Cell & bioscience · 2022Article
- Mining RNAseq data reveals dynamic metaboloepigenetic profiles in human, mouse and bovine pre-implantation embryos.iScience · 2022Article
- Chromatin as a sensor of metabolic changes during early development.Frontiers in cell and developmental biology · 2022Review
- Early cleaving embryos result in blastocysts with increased aspartate and glucose consumption, which exhibit different metabolic gene expression that persists in placental and fetal tissues.Journal of assisted reproduction and genetics · 2021Article
- c-MYC Triggers Lipid Remodelling During Early Somatic Cell Reprogramming to Pluripotency.Stem cell reviews and reports · 2021Article
- Article
- Metabolic programming of nephron progenitor cell fate.Pediatric nephrology (Berlin, Germany) · 2021Review
- Developmental and molecular response of bovine embryos to reduced nutrientsReproduction & fertility · 2020Article
- Unveiling dynamic metabolic signatures in human induced pluripotent and neural stem cells.PLoS computational biology · 2020Article
- Simulated microgravity significantly altered metabolism in epidermal stem cells.In vitro cellular & developmental biology. Animal · 2020Article
- Energy Metabolism Regulates Stem Cell Pluripotency.Frontiers in cell and developmental biology · 2020Review
- Lipid Mediated Regulation of Adult Stem Cell Behavior.Frontiers in cell and developmental biology · 2020Review
- Interplay between Metabolites and the Epigenome in Regulating Embryonic and Adult Stem Cell Potency and Maintenance.Stem cell reports · 2019Review
- Modeling Mammalian Commitment to the Neural Lineage Using Embryos and Embryonic Stem Cells.Frontiers in physiology · 2019Review
- Oxygen Regulates Human Pluripotent Stem Cell Metabolic Flux.Stem cells international · 2019Article
- Metabolism Is a Key Regulator of Induced Pluripotent Stem Cell Reprogramming.Stem cells international · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The differentiation of pluripotent stem cells is associated with extensive changes in metabolism, as well as widespread remodeling of the epigenetic landscape. Epigenetic regulation is essential for the modulation of differentiation, being responsible for cell type specific gene expression patterns through the modification of DNA and histones, thereby establishing cell identity. Each cell type has its own idiosyncratic pattern regarding the use of specific metabolic pathways. Rather than simply being perceived as a means of generating ATP and building blocks for cell growth and division, cellular metabolism can directly influence cellular regulation and the epigenome. Consequently, the significance of nutrients and metabolites as regulators of differentiation is central to understanding how cells interact with their immediate environment. This review serves to integrate studies on pluripotent stem cell metabolism, and the regulation of DNA methylation and acetylation and identifies areas in which current knowledge is limited.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.