Evidence map›Paper›PMID 26839554›Full record

ReviewStem cells international2016

Emerging Implications for Extracellular Matrix-Based Technologies in Vascularized Composite Allotransplantation.

Ricardo Londono, Vijay S Gorantla, Stephen F Badylak

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cells international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Ricardo LondonoMcGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 152192, USA; School of Medicine, University of Pittsburgh, Pittsburgh, PA 152613, USA.
Vijay S GorantlaMcGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 152192, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 152134, USA; Department of Plastic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 152615, USA.
Stephen F BadylakMcGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 152192, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 152134, USA; Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA.
University of Pittsburgh · USMcGowan Institute for Regenerative Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite recent progress in vascularized composite allotransplantation (VCA), limitations including complex, high dose immunosuppression regimens, lifelong risk of toxicity from immunosuppressants, acute and most critically chronic graft rejection, and suboptimal nerve regeneration remain particularly challenging obstacles restricting clinical progress. When properly configured, customized, and implemented, biomaterials derived from the extracellular matrix (ECM) retain bioactive molecules and immunomodulatory properties that can promote stem cell migration, proliferation and differentiation, and constructive functional tissue remodeling. The present paper reviews the emerging implications of ECM-based technologies in VCA, including local immunomodulation, tissue repair, nerve regeneration, minimally invasive graft targeted drug delivery, stem cell transplantation, and other donor graft manipulation.

Identifiers

PMID26839554
PMCPMC4709778
OpenAlexW2208622513

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.