ArticleCirculation research2016
A Large-Scale Investigation of Hypoxia-Preconditioned Allogeneic Mesenchymal Stem Cells for Myocardial Repair in Nonhuman Primates: Paracrine Activity Without Remuscularization.
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Article in Circulation research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers.
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121 citing papers in PubMed.
- Stem Cell Therapy: Past, Present, and Future Aspects.Biomedicines · 2026Review
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- Comparison of the Safety and Efficacy of Hypoxia-Conditioned Mesenchymal Stem Cells and Their Extracellular Vesicles in a Spinal Cord Injury Rat Model.Molecular neurobiology · 2026Article
- Hypoxic preconditioned mesenchymal stem cell-derived exosomes alleviate oxidative stress-induced cardiomyocyte apoptosis through miR-486-5p.World journal of stem cells · 2025Article
- Effects of hypoxic and photobiomodulation preconditioning on mesenchymal stem cell-derived exosomes: an in vitro study with an osteogenic potential approach.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025Article
- MSCs ameliorates hyperglycemia-induced endothelial injury through modulation of mitochondrial dynamics.Cell death & disease · 2025Article
- Intranasal delivery of hypoxia-preconditioned extracellular vesicles derived from BMSCs alleviates neuroinflammation and brain dysfunction in TBI.Stem cell research & therapy · 2025Article
- Rapid manufacturing of angiogenic cellular collagen patches for ischemic cardiomyopathy.Stem cells translational medicine · 2025Article
- Current status and new horizons in stem cell therapy in cardiovascular regenerative medicine (CaVaReM): an update.European journal of medical research · 2025Review
- Targeted delivery of engineered adipose-derived stem cell secretome to promote cardiac repair after myocardial infarction.Journal of controlled release : official journal of the Controlled Release Society · 2025Article
- PRMT1 inhibition enhances the cardioprotective effect of adipose-derived mesenchymal stem cells against myocardial infarction through RUNX1.Stem cell research & therapy · 2025Article
- Multifunctional magneto-electric and exosome-loaded hydrogel enhances neuronal differentiation and immunoregulation through remote non-invasive electrical stimulation for neurological recovery after spinal cord injury.Bioactive materials · 2025Article
- Interpenetrating network hydrogel-loaded embryonic stem cell-derived endocardial cells improves cardiac function after myocardial infarction.Journal of translational medicine · 2025Article
- L-arginine from elder human mesenchymal stem cells induces angiogenesis and enhances therapeutic effects on ischemic heart diseases.World journal of stem cells · 2025Article
- Innovative approaches to boost mesenchymal stem cells efficacy in myocardial infarction therapy.Materials today. Bio · 2025Review
- Cardiac preservation usingFrontiers in cardiovascular medicine · 2025Article
- Therapeutic Potential of Mesenchymal Stem Cell-Derived Exosomes in Spinal Cord Injury.Molecular neurobiology · 2025Review
- microRNAs shuttled by mesenchymal stromal cell-derived exosomes in coronary artery disease: A systematic review of preclinical studies.BioImpacts : BI · 2025Review
- N-CADHERINStem cell research & therapy · 2024Article
- Pretreatment with Notoginsenoside R1 enhances the efficacy of neonatal rat mesenchymal stem cell transplantation in model of myocardial infarction through regulating PI3K/Akt/FoxO1 signaling pathways.Stem cell research & therapy · 2024Article
61 more citing papers are in PubMed but not listed here.
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33 authors.
Xinyang HuFrom the Department of Cardiology (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J. L., J.Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.), Department of Cardiovascular Surgery (H.C., M.K.), Department of Anesthesiology (F.Z., Q.C.), Department of Radiology, (J.S., Qian Li), Department of Nuclear Medicine (H.Z.), and Department of Ultrasonography (Q.Y., L.Y.), Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, People's Republic of China (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J.L., J. Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.); Institute of Translational Medicine, Zhejiang University, Hangzhou, People's Republic of China (J.C.); and Department of Biomedical Engineering, University of Alabama at Birmingham (J. Zhang).
Yinchuan XuFrom the Department of Cardiology (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J. L., J.Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.), Department of Cardiovascular Surgery (H.C., M.K.), Department of Anesthesiology (F.Z., Q.C.), Department of Radiology, (J.S., Qian Li), Department of Nuclear Medicine (H.Z.), and Department of Ultrasonography (Q.Y., L.Y.), Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, People's Republic of China (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J.L., J. Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.); Institute of Translational Medicine, Zhejiang University, Hangzhou, People's Republic of China (J.C.); and Department of Biomedical Engineering, University of Alabama at Birmingham (J. Zhang).
Zhiwei ZhongFrom the Department of Cardiology (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J. L., J.Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.), Department of Cardiovascular Surgery (H.C., M.K.), Department of Anesthesiology (F.Z., Q.C.), Department of Radiology, (J.S., Qian Li), Department of Nuclear Medicine (H.Z.), and Department of Ultrasonography (Q.Y., L.Y.), Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, People's Republic of China (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J.L., J. Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.); Institute of Translational Medicine, Zhejiang University, Hangzhou, People's Republic of China (J.C.); and Department of Biomedical Engineering, University of Alabama at Birmingham (J. Zhang).
Yan WuFrom the Department of Cardiology (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J. L., J.Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.), Department of Cardiovascular Surgery (H.C., M.K.), Department of Anesthesiology (F.Z., Q.C.), Department of Radiology, (J.S., Qian Li), Department of Nuclear Medicine (H.Z.), and Department of Ultrasonography (Q.Y., L.Y.), Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, People's Republic of China (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J.L., J. Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.); Institute of Translational Medicine, Zhejiang University, Hangzhou, People's Republic of China (J.C.); and Department of Biomedical Engineering, University of Alabama at Birmingham (J. Zhang).
Jing ZhaoFrom the Department of Cardiology (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J. L., J.Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.), Department of Cardiovascular Surgery (H.C., M.K.), Department of Anesthesiology (F.Z., Q.C.), Department of Radiology, (J.S., Qian Li), Department of Nuclear Medicine (H.Z.), and Department of Ultrasonography (Q.Y., L.Y.), Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, People's Republic of China (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J.L., J. Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.); Institute of Translational Medicine, Zhejiang University, Hangzhou, People's Republic of China (J.C.); and Department of Biomedical Engineering, University of Alabama at Birmingham (J. Zhang).
Yingchao WangFrom the Department of Cardiology (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J. L., J.Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.), Department of Cardiovascular Surgery (H.C., M.K.), Department of Anesthesiology (F.Z., Q.C.), Department of Radiology, (J.S., Qian Li), Department of Nuclear Medicine (H.Z.), and Department of Ultrasonography (Q.Y., L.Y.), Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, People's Republic of China (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J.L., J. Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.); Institute of Translational Medicine, Zhejiang University, Hangzhou, People's Republic of China (J.C.); and Department of Biomedical Engineering, University of Alabama at Birmingham (J. Zhang).
Haifeng ChengFrom the Department of Cardiology (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J. L., J.Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.), Department of Cardiovascular Surgery (H.C., M.K.), Department of Anesthesiology (F.Z., Q.C.), Department of Radiology, (J.S., Qian Li), Department of Nuclear Medicine (H.Z.), and Department of Ultrasonography (Q.Y., L.Y.), Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, People's Republic of China (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J.L., J. Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.); Institute of Translational Medicine, Zhejiang University, Hangzhou, People's Republic of China (J.C.); and Department of Biomedical Engineering, University of Alabama at Birmingham (J. Zhang).
Minjian KongFrom the Department of Cardiology (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J. L., J.Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.), Department of Cardiovascular Surgery (H.C., M.K.), Department of Anesthesiology (F.Z., Q.C.), Department of Radiology, (J.S., Qian Li), Department of Nuclear Medicine (H.Z.), and Department of Ultrasonography (Q.Y., L.Y.), Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, People's Republic of China (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J.L., J. Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.); Institute of Translational Medicine, Zhejiang University, Hangzhou, People's Republic of China (J.C.); and Department of Biomedical Engineering, University of Alabama at Birmingham (J. Zhang).
Fengjiang ZhangFrom the Department of Cardiology (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J. L., J.Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.), Department of Cardiovascular Surgery (H.C., M.K.), Department of Anesthesiology (F.Z., Q.C.), Department of Radiology, (J.S., Qian Li), Department of Nuclear Medicine (H.Z.), and Department of Ultrasonography (Q.Y., L.Y.), Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, People's Republic of China (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J.L., J. Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.); Institute of Translational Medicine, Zhejiang University, Hangzhou, People's Republic of China (J.C.); and Department of Biomedical Engineering, University of Alabama at Birmingham (J. Zhang).
Qi ChenFrom the Department of Cardiology (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J. L., J.Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.), Department of Cardiovascular Surgery (H.C., M.K.), Department of Anesthesiology (F.Z., Q.C.), Department of Radiology, (J.S., Qian Li), Department of Nuclear Medicine (H.Z.), and Department of Ultrasonography (Q.Y., L.Y.), Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, People's Republic of China (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J.L., J. Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.); Institute of Translational Medicine, Zhejiang University, Hangzhou, People's Republic of China (J.C.); and Department of Biomedical Engineering, University of Alabama at Birmingham (J. Zhang).
Jianzhong SunFrom the Department of Cardiology (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J. L., J.Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.), Department of Cardiovascular Surgery (H.C., M.K.), Department of Anesthesiology (F.Z., Q.C.), Department of Radiology, (J.S., Qian Li), Department of Nuclear Medicine (H.Z.), and Department of Ultrasonography (Q.Y., L.Y.), Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, People's Republic of China (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J.L., J. Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.); Institute of Translational Medicine, Zhejiang University, Hangzhou, People's Republic of China (J.C.); and Department of Biomedical Engineering, University of Alabama at Birmingham (J. Zhang).
Qian LiFrom the Department of Cardiology (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J. L., J.Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.), Department of Cardiovascular Surgery (H.C., M.K.), Department of Anesthesiology (F.Z., Q.C.), Department of Radiology, (J.S., Qian Li), Department of Nuclear Medicine (H.Z.), and Department of Ultrasonography (Q.Y., L.Y.), Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, People's Republic of China (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J.L., J. Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.); Institute of Translational Medicine, Zhejiang University, Hangzhou, People's Republic of China (J.C.); and Department of Biomedical Engineering, University of Alabama at Birmingham (J. Zhang).
Jing JinFrom the Department of Cardiology (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J. L., J.Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.), Department of Cardiovascular Surgery (H.C., M.K.), Department of Anesthesiology (F.Z., Q.C.), Department of Radiology, (J.S., Qian Li), Department of Nuclear Medicine (H.Z.), and Department of Ultrasonography (Q.Y., L.Y.), Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, People's Republic of China (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J.L., J. Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.); Institute of Translational Medicine, Zhejiang University, Hangzhou, People's Republic of China (J.C.); and Department of Biomedical Engineering, University of Alabama at Birmingham (J. Zhang).
Qingju LiFrom the Department of Cardiology (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J. L., J.Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.), Department of Cardiovascular Surgery (H.C., M.K.), Department of Anesthesiology (F.Z., Q.C.), Department of Radiology, (J.S., Qian Li), Department of Nuclear Medicine (H.Z.), and Department of Ultrasonography (Q.Y., L.Y.), Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, People's Republic of China (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J.L., J. Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.); Institute of Translational Medicine, Zhejiang University, Hangzhou, People's Republic of China (J.C.); and Department of Biomedical Engineering, University of Alabama at Birmingham (J. Zhang).
Lihong ChenFrom the Department of Cardiology (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J. L., J.Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.), Department of Cardiovascular Surgery (H.C., M.K.), Department of Anesthesiology (F.Z., Q.C.), Department of Radiology, (J.S., Qian Li), Department of Nuclear Medicine (H.Z.), and Department of Ultrasonography (Q.Y., L.Y.), Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, People's Republic of China (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J.L., J. Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.); Institute of Translational Medicine, Zhejiang University, Hangzhou, People's Republic of China (J.C.); and Department of Biomedical Engineering, University of Alabama at Birmingham (J. Zhang).
Chen WangFrom the Department of Cardiology (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J. L., J.Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.), Department of Cardiovascular Surgery (H.C., M.K.), Department of Anesthesiology (F.Z., Q.C.), Department of Radiology, (J.S., Qian Li), Department of Nuclear Medicine (H.Z.), and Department of Ultrasonography (Q.Y., L.Y.), Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, People's Republic of China (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J.L., J. Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.); Institute of Translational Medicine, Zhejiang University, Hangzhou, People's Republic of China (J.C.); and Department of Biomedical Engineering, University of Alabama at Birmingham (J. Zhang).
Hongwei ZhanFrom the Department of Cardiology (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J. L., J.Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.), Department of Cardiovascular Surgery (H.C., M.K.), Department of Anesthesiology (F.Z., Q.C.), Department of Radiology, (J.S., Qian Li), Department of Nuclear Medicine (H.Z.), and Department of Ultrasonography (Q.Y., L.Y.), Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, People's Republic of China (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J.L., J. Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.); Institute of Translational Medicine, Zhejiang University, Hangzhou, People's Republic of China (J.C.); and Department of Biomedical Engineering, University of Alabama at Birmingham (J. Zhang).
Youqi FanFrom the Department of Cardiology (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J. L., J.Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.), Department of Cardiovascular Surgery (H.C., M.K.), Department of Anesthesiology (F.Z., Q.C.), Department of Radiology, (J.S., Qian Li), Department of Nuclear Medicine (H.Z.), and Department of Ultrasonography (Q.Y., L.Y.), Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, People's Republic of China (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J.L., J. Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.); Institute of Translational Medicine, Zhejiang University, Hangzhou, People's Republic of China (J.C.); and Department of Biomedical Engineering, University of Alabama at Birmingham (J. Zhang).
Qian YangFrom the Department of Cardiology (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J. L., J.Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.), Department of Cardiovascular Surgery (H.C., M.K.), Department of Anesthesiology (F.Z., Q.C.), Department of Radiology, (J.S., Qian Li), Department of Nuclear Medicine (H.Z.), and Department of Ultrasonography (Q.Y., L.Y.), Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, People's Republic of China (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J.L., J. Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.); Institute of Translational Medicine, Zhejiang University, Hangzhou, People's Republic of China (J.C.); and Department of Biomedical Engineering, University of Alabama at Birmingham (J. Zhang).
Lei YuFrom the Department of Cardiology (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J. L., J.Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.), Department of Cardiovascular Surgery (H.C., M.K.), Department of Anesthesiology (F.Z., Q.C.), Department of Radiology, (J.S., Qian Li), Department of Nuclear Medicine (H.Z.), and Department of Ultrasonography (Q.Y., L.Y.), Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, People's Republic of China (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J.L., J. Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.); Institute of Translational Medicine, Zhejiang University, Hangzhou, People's Republic of China (J.C.); and Department of Biomedical Engineering, University of Alabama at Birmingham (J. Zhang).
Rongrong WuFrom the Department of Cardiology (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J. L., J.Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.), Department of Cardiovascular Surgery (H.C., M.K.), Department of Anesthesiology (F.Z., Q.C.), Department of Radiology, (J.S., Qian Li), Department of Nuclear Medicine (H.Z.), and Department of Ultrasonography (Q.Y., L.Y.), Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, People's Republic of China (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J.L., J. Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.); Institute of Translational Medicine, Zhejiang University, Hangzhou, People's Republic of China (J.C.); and Department of Biomedical Engineering, University of Alabama at Birmingham (J. Zhang).
Jie LiangFrom the Department of Cardiology (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J. L., J.Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.), Department of Cardiovascular Surgery (H.C., M.K.), Department of Anesthesiology (F.Z., Q.C.), Department of Radiology, (J.S., Qian Li), Department of Nuclear Medicine (H.Z.), and Department of Ultrasonography (Q.Y., L.Y.), Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, People's Republic of China (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J.L., J. Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.); Institute of Translational Medicine, Zhejiang University, Hangzhou, People's Republic of China (J.C.); and Department of Biomedical Engineering, University of Alabama at Birmingham (J. Zhang).
Jinyun ZhuFrom the Department of Cardiology (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J. L., J.Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.), Department of Cardiovascular Surgery (H.C., M.K.), Department of Anesthesiology (F.Z., Q.C.), Department of Radiology, (J.S., Qian Li), Department of Nuclear Medicine (H.Z.), and Department of Ultrasonography (Q.Y., L.Y.), Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, People's Republic of China (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J.L., J. Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.); Institute of Translational Medicine, Zhejiang University, Hangzhou, People's Republic of China (J.C.); and Department of Biomedical Engineering, University of Alabama at Birmingham (J. Zhang).
Ya WangFrom the Department of Cardiology (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J. L., J.Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.), Department of Cardiovascular Surgery (H.C., M.K.), Department of Anesthesiology (F.Z., Q.C.), Department of Radiology, (J.S., Qian Li), Department of Nuclear Medicine (H.Z.), and Department of Ultrasonography (Q.Y., L.Y.), Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, People's Republic of China (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J.L., J. Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.); Institute of Translational Medicine, Zhejiang University, Hangzhou, People's Republic of China (J.C.); and Department of Biomedical Engineering, University of Alabama at Birmingham (J. Zhang).
Yiping JinFrom the Department of Cardiology (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J. L., J.Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.), Department of Cardiovascular Surgery (H.C., M.K.), Department of Anesthesiology (F.Z., Q.C.), Department of Radiology, (J.S., Qian Li), Department of Nuclear Medicine (H.Z.), and Department of Ultrasonography (Q.Y., L.Y.), Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, People's Republic of China (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J.L., J. Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.); Institute of Translational Medicine, Zhejiang University, Hangzhou, People's Republic of China (J.C.); and Department of Biomedical Engineering, University of Alabama at Birmingham (J. Zhang).
Yifan LinFrom the Department of Cardiology (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J. L., J.Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.), Department of Cardiovascular Surgery (H.C., M.K.), Department of Anesthesiology (F.Z., Q.C.), Department of Radiology, (J.S., Qian Li), Department of Nuclear Medicine (H.Z.), and Department of Ultrasonography (Q.Y., L.Y.), Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, People's Republic of China (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J.L., J. Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.); Institute of Translational Medicine, Zhejiang University, Hangzhou, People's Republic of China (J.C.); and Department of Biomedical Engineering, University of Alabama at Birmingham (J. Zhang).
Fan YangFrom the Department of Cardiology (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J. L., J.Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.), Department of Cardiovascular Surgery (H.C., M.K.), Department of Anesthesiology (F.Z., Q.C.), Department of Radiology, (J.S., Qian Li), Department of Nuclear Medicine (H.Z.), and Department of Ultrasonography (Q.Y., L.Y.), Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, People's Republic of China (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J.L., J. Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.); Institute of Translational Medicine, Zhejiang University, Hangzhou, People's Republic of China (J.C.); and Department of Biomedical Engineering, University of Alabama at Birmingham (J. Zhang).
Liangliang JiaFrom the Department of Cardiology (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J. L., J.Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.), Department of Cardiovascular Surgery (H.C., M.K.), Department of Anesthesiology (F.Z., Q.C.), Department of Radiology, (J.S., Qian Li), Department of Nuclear Medicine (H.Z.), and Department of Ultrasonography (Q.Y., L.Y.), Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, People's Republic of China (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J.L., J. Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.); Institute of Translational Medicine, Zhejiang University, Hangzhou, People's Republic of China (J.C.); and Department of Biomedical Engineering, University of Alabama at Birmingham (J. Zhang).
Wei ZhuFrom the Department of Cardiology (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J. L., J.Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.), Department of Cardiovascular Surgery (H.C., M.K.), Department of Anesthesiology (F.Z., Q.C.), Department of Radiology, (J.S., Qian Li), Department of Nuclear Medicine (H.Z.), and Department of Ultrasonography (Q.Y., L.Y.), Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, People's Republic of China (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J.L., J. Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.); Institute of Translational Medicine, Zhejiang University, Hangzhou, People's Republic of China (J.C.); and Department of Biomedical Engineering, University of Alabama at Birmingham (J. Zhang).
Jinghai ChenFrom the Department of Cardiology (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J. L., J.Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.), Department of Cardiovascular Surgery (H.C., M.K.), Department of Anesthesiology (F.Z., Q.C.), Department of Radiology, (J.S., Qian Li), Department of Nuclear Medicine (H.Z.), and Department of Ultrasonography (Q.Y., L.Y.), Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, People's Republic of China (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J.L., J. Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.); Institute of Translational Medicine, Zhejiang University, Hangzhou, People's Republic of China (J.C.); and Department of Biomedical Engineering, University of Alabama at Birmingham (J. Zhang).
Hong YuFrom the Department of Cardiology (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J. L., J.Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.), Department of Cardiovascular Surgery (H.C., M.K.), Department of Anesthesiology (F.Z., Q.C.), Department of Radiology, (J.S., Qian Li), Department of Nuclear Medicine (H.Z.), and Department of Ultrasonography (Q.Y., L.Y.), Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, People's Republic of China (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J.L., J. Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.); Institute of Translational Medicine, Zhejiang University, Hangzhou, People's Republic of China (J.C.); and Department of Biomedical Engineering, University of Alabama at Birmingham (J. Zhang).
Jianyi ZhangFrom the Department of Cardiology (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J. L., J.Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.), Department of Cardiovascular Surgery (H.C., M.K.), Department of Anesthesiology (F.Z., Q.C.), Department of Radiology, (J.S., Qian Li), Department of Nuclear Medicine (H.Z.), and Department of Ultrasonography (Q.Y., L.Y.), Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, People's Republic of China (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J.L., J. Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.); Institute of Translational Medicine, Zhejiang University, Hangzhou, People's Republic of China (J.C.); and Department of Biomedical Engineering, University of Alabama at Birmingham (J. Zhang). jian_an_wang@yahoo.com Jayzhang@uab.edu.
Jian'an WangFrom the Department of Cardiology (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J. L., J.Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.), Department of Cardiovascular Surgery (H.C., M.K.), Department of Anesthesiology (F.Z., Q.C.), Department of Radiology, (J.S., Qian Li), Department of Nuclear Medicine (H.Z.), and Department of Ultrasonography (Q.Y., L.Y.), Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, People's Republic of China (X.H., Y.X., Z.Z., Y. Wu, J. Zhao, Yingchao Wang, J.J., Qingju Li, L.C., C.W., Y.F., R.W., J.L., J. Zhu, Ya Wang, Y.J., Y.L., F.Y., L.J., W.Z., J.C., H.Y., J.W.); Institute of Translational Medicine, Zhejiang University, Hangzhou, People's Republic of China (J.C.); and Department of Biomedical Engineering, University of Alabama at Birmingham (J. Zhang). jian_an_wang@yahoo.com Jayzhang@uab.edu.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleThe effectiveness of transplanted bone marrow mesenchymal stem cells (MSCs) for cardiac repair has been limited; thus, strategies for optimizing stem-cell-based myocardial therapy are needed.
objectiveThe present study was designed to test our central hypothesis that hypoxia-preconditioned MSCs (HP-MSCs) are more effective than MSCs cultured under ambient oxygen levels for the treatment of myocardial injury in a large-scale (N=49), long-term (9 months), nonhuman primate (Cynomolgous monkeys) investigation. METHODS AND
resultsMSCs were engineered to express green fluorescent protein, cultured under ambient oxygen or 0.5% oxygen (HP-MSCs) for 24 hours and then tested in the infarcted hearts of Cynomolgus monkeys (1×10(7) cells per heart). Hypoxia preconditioning increased the expression of several prosurvival/proangiogenic factors in cultured MSCs, and measurements of infarct size and left-ventricular function at day 90 after myocardial infarction were significantly more improved in monkeys treated with HP-MSCs than in monkeys treated with the control vehicle; functional improvements in normal cultured bone marrow mesenchymal stem cells-treated monkeys were not significant. HP-MSCs transplantation was also associated with increases in cardiomyocyte proliferation, vascular density, myocardial glucose uptake, and engraftment of the transplanted cells and with declines in endogenous cell apoptosis, but did not increase the occurrence of arrhythmogenic complications.
conclusionsHypoxia preconditioning improved the effectiveness of MSCs transplantation for the treatment of myocardial infarction in nonhuman primates without increasing the occurrence of arrhythmogenic complications, which suggests that future clinical trials of HP-MSCs transplantation are warranted.
Indexed as
Myocardial RevascularizationAnimalsCell HypoxiaCell ProliferationCells, CulturedIschemic Preconditioning, MyocardialMacaca fascicularisMaleMesenchymal Stem CellsMesenchymal Stem Cell TransplantationMyocardial InfarctionParacrine CommunicationPrimatesTransplantation, HomologousCynomolgous monkeyshypoxia preconditioningmesenchymal stem cellsmyocardial infarction
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