ArticleCirculation research2016
Mutual Regulation of Epicardial Adipose Tissue and Myocardial Redox State by PPAR-γ/Adiponectin Signalling.
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Article in Circulation research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.
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94 citing papers in PubMed, 165 citations in OpenAlex.
- Sulfur amino acid restriction and caloric restriction induce divergent redox metabolism-related adaptations in male F344 rats.Redox report : communications in free radical research · 2026Article
- Epicardial Versus Circulating Adiponectin: An Unresolved Distinction in Liraglutide's Anti-Arrhythmic Mechanism.Cardiovascular drugs and therapy · 2026Article
- AI-Enabled Echocardiography Identifies Prominent Epicardial Adipose Tissue Associated With an Adverse Cardiometabolic Profile.medRxiv : the preprint server for health sciences · 2026Article
- Molecular Basis of Adipose-Cardiac Crosstalk in Cardiovascular Diseases: From Mechanisms to Therapeutic Opportunities.Biomolecules · 2026Review
- Early Prediction of Heart Failure From Routine Cardiac CT Using Radiomic Phenotyping of Epicardial Fat.Journal of the American College of Cardiology · 2026Article
- Role of adipose tissue in cardiovascular health and diseases.Chinese medical journal · 2026Review
- Review
- Epicardial Adipose Tissue as a Cardiometabolic Target in Atrial Fibrillation: Implications for Ablation Strategies and Emerging Metabolic Therapies.Medical sciences (Basel, Switzerland) · 2026Review
- Arrhythmia-induced cardiomyopathy: focus on atrial fibrillation.Nature reviews. Cardiology · 2026Review
- Relationship Between Perivascular Fat Inflammation and Coronary Atherosclerotic Plaque Composition.Journal of clinical medicine · 2026Article
- Heart matters: How glucose- and lipid-modulating drugs remodel epicardial adipose tissue accumulation, inflammatory patterns and browning.Diabetes, obesity & metabolism · 2026Review
- Perivascular Adipose Tissue Radiomics Predicts Abdominal Aortic Aneurysm Rupture: A Multicenter Study.Vascular health and risk management · 2026Article
- Epicardial adipose tissue as a metabolically active visceral fat depot: an emerging target in cardiovascular disease.Frontiers in cardiovascular medicine · 2026Review
- Lipoprotein(a) and Vascular Redox State in Patients With Advanced Coronary Atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2026Article
- Epicardial adipose tissue in cardiovascular diseases: a potential therapeutic target.Frontiers in cardiovascular medicine · 2026Review
- Epicardial adipose tissue: an overtly concealed contributor to cardiovascular events in chronic kidney disease patients.Lipids in health and disease · 2025Review
- Machine learning-based radiomic features of perivascular adipose tissue in coronary computed tomography angiography predicting inflammation status around atherosclerotic plaque: a retrospective cohort study.Annals of medicine · 2025Article
- Heart-guarding or heart-harming? The dual role of epicardial adipose tissue in cardiovascular health and disease.International journal of obesity (2005) · 2025Review
- Arrhythmia-Induced Cardiomyopathy in Atrial Fibrillation: Pathogenesis, Diagnosis, and Treatment.Life (Basel, Switzerland) · 2025Review
- Sex-specific metabolic responses to high-fat diet in mice with NOX4 deficiency.Redox biology · 2025Article
34 more citing papers are in PubMed but not listed here.
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Authors and funding
20 authors at 2 institutions in 2 countries.
Alexios S AntonopoulosFrom the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom (A.S.A., M.M., A.R., F.S., L.H., C.P., P.C., I.A., A.T., B.C., K.M.C., C.A.); Cardiac Electrophysiology Group, Department of Physiology, Maastricht University, Maastricht, The Netherlands (S.V., H.N.); Department of Cardiology, Athens University Medical School, Athens, Greece (D.T.); Cardiovascular Division, King's College London BHF Centre, London, United Kingdom (A.C.B., A.M.S.); and Department of Cardiac Surgery, John Radcliffe Hospital, Oxford, United Kingdom (R.S., G.K., M.P.).
Marios MargaritisFrom the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom (A.S.A., M.M., A.R., F.S., L.H., C.P., P.C., I.A., A.T., B.C., K.M.C., C.A.); Cardiac Electrophysiology Group, Department of Physiology, Maastricht University, Maastricht, The Netherlands (S.V., H.N.); Department of Cardiology, Athens University Medical School, Athens, Greece (D.T.); Cardiovascular Division, King's College London BHF Centre, London, United Kingdom (A.C.B., A.M.S.); and Department of Cardiac Surgery, John Radcliffe Hospital, Oxford, United Kingdom (R.S., G.K., M.P.).
Sander VerheuleFrom the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom (A.S.A., M.M., A.R., F.S., L.H., C.P., P.C., I.A., A.T., B.C., K.M.C., C.A.); Cardiac Electrophysiology Group, Department of Physiology, Maastricht University, Maastricht, The Netherlands (S.V., H.N.); Department of Cardiology, Athens University Medical School, Athens, Greece (D.T.); Cardiovascular Division, King's College London BHF Centre, London, United Kingdom (A.C.B., A.M.S.); and Department of Cardiac Surgery, John Radcliffe Hospital, Oxford, United Kingdom (R.S., G.K., M.P.).
Alice RecaldeFrom the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom (A.S.A., M.M., A.R., F.S., L.H., C.P., P.C., I.A., A.T., B.C., K.M.C., C.A.); Cardiac Electrophysiology Group, Department of Physiology, Maastricht University, Maastricht, The Netherlands (S.V., H.N.); Department of Cardiology, Athens University Medical School, Athens, Greece (D.T.); Cardiovascular Division, King's College London BHF Centre, London, United Kingdom (A.C.B., A.M.S.); and Department of Cardiac Surgery, John Radcliffe Hospital, Oxford, United Kingdom (R.S., G.K., M.P.).
Fabio SannaFrom the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom (A.S.A., M.M., A.R., F.S., L.H., C.P., P.C., I.A., A.T., B.C., K.M.C., C.A.); Cardiac Electrophysiology Group, Department of Physiology, Maastricht University, Maastricht, The Netherlands (S.V., H.N.); Department of Cardiology, Athens University Medical School, Athens, Greece (D.T.); Cardiovascular Division, King's College London BHF Centre, London, United Kingdom (A.C.B., A.M.S.); and Department of Cardiac Surgery, John Radcliffe Hospital, Oxford, United Kingdom (R.S., G.K., M.P.).
Laura HerdmanFrom the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom (A.S.A., M.M., A.R., F.S., L.H., C.P., P.C., I.A., A.T., B.C., K.M.C., C.A.); Cardiac Electrophysiology Group, Department of Physiology, Maastricht University, Maastricht, The Netherlands (S.V., H.N.); Department of Cardiology, Athens University Medical School, Athens, Greece (D.T.); Cardiovascular Division, King's College London BHF Centre, London, United Kingdom (A.C.B., A.M.S.); and Department of Cardiac Surgery, John Radcliffe Hospital, Oxford, United Kingdom (R.S., G.K., M.P.).
Costas PsarrosFrom the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom (A.S.A., M.M., A.R., F.S., L.H., C.P., P.C., I.A., A.T., B.C., K.M.C., C.A.); Cardiac Electrophysiology Group, Department of Physiology, Maastricht University, Maastricht, The Netherlands (S.V., H.N.); Department of Cardiology, Athens University Medical School, Athens, Greece (D.T.); Cardiovascular Division, King's College London BHF Centre, London, United Kingdom (A.C.B., A.M.S.); and Department of Cardiac Surgery, John Radcliffe Hospital, Oxford, United Kingdom (R.S., G.K., M.P.).
Hussein NasrallahFrom the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom (A.S.A., M.M., A.R., F.S., L.H., C.P., P.C., I.A., A.T., B.C., K.M.C., C.A.); Cardiac Electrophysiology Group, Department of Physiology, Maastricht University, Maastricht, The Netherlands (S.V., H.N.); Department of Cardiology, Athens University Medical School, Athens, Greece (D.T.); Cardiovascular Division, King's College London BHF Centre, London, United Kingdom (A.C.B., A.M.S.); and Department of Cardiac Surgery, John Radcliffe Hospital, Oxford, United Kingdom (R.S., G.K., M.P.).
Patricia CoutinhoFrom the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom (A.S.A., M.M., A.R., F.S., L.H., C.P., P.C., I.A., A.T., B.C., K.M.C., C.A.); Cardiac Electrophysiology Group, Department of Physiology, Maastricht University, Maastricht, The Netherlands (S.V., H.N.); Department of Cardiology, Athens University Medical School, Athens, Greece (D.T.); Cardiovascular Division, King's College London BHF Centre, London, United Kingdom (A.C.B., A.M.S.); and Department of Cardiac Surgery, John Radcliffe Hospital, Oxford, United Kingdom (R.S., G.K., M.P.).
Ioannis AkoumianakisFrom the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom (A.S.A., M.M., A.R., F.S., L.H., C.P., P.C., I.A., A.T., B.C., K.M.C., C.A.); Cardiac Electrophysiology Group, Department of Physiology, Maastricht University, Maastricht, The Netherlands (S.V., H.N.); Department of Cardiology, Athens University Medical School, Athens, Greece (D.T.); Cardiovascular Division, King's College London BHF Centre, London, United Kingdom (A.C.B., A.M.S.); and Department of Cardiac Surgery, John Radcliffe Hospital, Oxford, United Kingdom (R.S., G.K., M.P.).
Alison C BrewerFrom the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom (A.S.A., M.M., A.R., F.S., L.H., C.P., P.C., I.A., A.T., B.C., K.M.C., C.A.); Cardiac Electrophysiology Group, Department of Physiology, Maastricht University, Maastricht, The Netherlands (S.V., H.N.); Department of Cardiology, Athens University Medical School, Athens, Greece (D.T.); Cardiovascular Division, King's College London BHF Centre, London, United Kingdom (A.C.B., A.M.S.); and Department of Cardiac Surgery, John Radcliffe Hospital, Oxford, United Kingdom (R.S., G.K., M.P.).
Rana SayeedFrom the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom (A.S.A., M.M., A.R., F.S., L.H., C.P., P.C., I.A., A.T., B.C., K.M.C., C.A.); Cardiac Electrophysiology Group, Department of Physiology, Maastricht University, Maastricht, The Netherlands (S.V., H.N.); Department of Cardiology, Athens University Medical School, Athens, Greece (D.T.); Cardiovascular Division, King's College London BHF Centre, London, United Kingdom (A.C.B., A.M.S.); and Department of Cardiac Surgery, John Radcliffe Hospital, Oxford, United Kingdom (R.S., G.K., M.P.).
George KrasopoulosFrom the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom (A.S.A., M.M., A.R., F.S., L.H., C.P., P.C., I.A., A.T., B.C., K.M.C., C.A.); Cardiac Electrophysiology Group, Department of Physiology, Maastricht University, Maastricht, The Netherlands (S.V., H.N.); Department of Cardiology, Athens University Medical School, Athens, Greece (D.T.); Cardiovascular Division, King's College London BHF Centre, London, United Kingdom (A.C.B., A.M.S.); and Department of Cardiac Surgery, John Radcliffe Hospital, Oxford, United Kingdom (R.S., G.K., M.P.).
Mario PetrouFrom the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom (A.S.A., M.M., A.R., F.S., L.H., C.P., P.C., I.A., A.T., B.C., K.M.C., C.A.); Cardiac Electrophysiology Group, Department of Physiology, Maastricht University, Maastricht, The Netherlands (S.V., H.N.); Department of Cardiology, Athens University Medical School, Athens, Greece (D.T.); Cardiovascular Division, King's College London BHF Centre, London, United Kingdom (A.C.B., A.M.S.); and Department of Cardiac Surgery, John Radcliffe Hospital, Oxford, United Kingdom (R.S., G.K., M.P.).
Akansha TarunFrom the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom (A.S.A., M.M., A.R., F.S., L.H., C.P., P.C., I.A., A.T., B.C., K.M.C., C.A.); Cardiac Electrophysiology Group, Department of Physiology, Maastricht University, Maastricht, The Netherlands (S.V., H.N.); Department of Cardiology, Athens University Medical School, Athens, Greece (D.T.); Cardiovascular Division, King's College London BHF Centre, London, United Kingdom (A.C.B., A.M.S.); and Department of Cardiac Surgery, John Radcliffe Hospital, Oxford, United Kingdom (R.S., G.K., M.P.).
Dimitris TousoulisFrom the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom (A.S.A., M.M., A.R., F.S., L.H., C.P., P.C., I.A., A.T., B.C., K.M.C., C.A.); Cardiac Electrophysiology Group, Department of Physiology, Maastricht University, Maastricht, The Netherlands (S.V., H.N.); Department of Cardiology, Athens University Medical School, Athens, Greece (D.T.); Cardiovascular Division, King's College London BHF Centre, London, United Kingdom (A.C.B., A.M.S.); and Department of Cardiac Surgery, John Radcliffe Hospital, Oxford, United Kingdom (R.S., G.K., M.P.).
Ajay M ShahFrom the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom (A.S.A., M.M., A.R., F.S., L.H., C.P., P.C., I.A., A.T., B.C., K.M.C., C.A.); Cardiac Electrophysiology Group, Department of Physiology, Maastricht University, Maastricht, The Netherlands (S.V., H.N.); Department of Cardiology, Athens University Medical School, Athens, Greece (D.T.); Cardiovascular Division, King's College London BHF Centre, London, United Kingdom (A.C.B., A.M.S.); and Department of Cardiac Surgery, John Radcliffe Hospital, Oxford, United Kingdom (R.S., G.K., M.P.).
Barbara CasadeiFrom the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom (A.S.A., M.M., A.R., F.S., L.H., C.P., P.C., I.A., A.T., B.C., K.M.C., C.A.); Cardiac Electrophysiology Group, Department of Physiology, Maastricht University, Maastricht, The Netherlands (S.V., H.N.); Department of Cardiology, Athens University Medical School, Athens, Greece (D.T.); Cardiovascular Division, King's College London BHF Centre, London, United Kingdom (A.C.B., A.M.S.); and Department of Cardiac Surgery, John Radcliffe Hospital, Oxford, United Kingdom (R.S., G.K., M.P.).
Keith M ChannonFrom the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom (A.S.A., M.M., A.R., F.S., L.H., C.P., P.C., I.A., A.T., B.C., K.M.C., C.A.); Cardiac Electrophysiology Group, Department of Physiology, Maastricht University, Maastricht, The Netherlands (S.V., H.N.); Department of Cardiology, Athens University Medical School, Athens, Greece (D.T.); Cardiovascular Division, King's College London BHF Centre, London, United Kingdom (A.C.B., A.M.S.); and Department of Cardiac Surgery, John Radcliffe Hospital, Oxford, United Kingdom (R.S., G.K., M.P.).
Charalambos AntoniadesFrom the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom (A.S.A., M.M., A.R., F.S., L.H., C.P., P.C., I.A., A.T., B.C., K.M.C., C.A.); Cardiac Electrophysiology Group, Department of Physiology, Maastricht University, Maastricht, The Netherlands (S.V., H.N.); Department of Cardiology, Athens University Medical School, Athens, Greece (D.T.); Cardiovascular Division, King's College London BHF Centre, London, United Kingdom (A.C.B., A.M.S.); and Department of Cardiac Surgery, John Radcliffe Hospital, Oxford, United Kingdom (R.S., G.K., M.P.). antoniad@well.ox.ac.uk.
King's College London · GBMaastricht University · NL
Funding
British Heart Foundation FS/11/66/28855British Heart Foundation FS/16/15/32047British Heart Foundation PG/13/56/30383British Heart Foundation PG/15/27/31374British Heart Foundation RG/11/15/29375British Heart Foundation RG/12/5/29576British Heart Foundation RG/13/11/30384
Abstract
rationaleAdiponectin has anti-inflammatory effects in experimental models, but its role in the regulation of myocardial redox state in humans is unknown. Although adiponectin is released from epicardial adipose tissue (EpAT), it is unclear whether it exerts any paracrine effects on the human myocardium.
objectiveTo explore the cross talk between EpAT-derived adiponectin and myocardial redox state in the human heart. METHODS AND
resultsEpAT and atrial myocardium were obtained from 306 patients undergoing coronary artery bypass grafting. Functional genetic polymorphisms that increase ADIPOQ expression (encoding adiponectin) led to reduced myocardial nicotinamide adenine dinucleotide phosphate oxidase-derived O2 (-), whereas circulating adiponectin and ADIPOQ expression in EpAT were associated with elevated myocardial O2 (-). In human atrial tissue, we demonstrated that adiponectin suppresses myocardial nicotinamide adenine dinucleotide phosphate oxidase activity, by preventing AMP kinase-mediated translocation of Rac1 and p47(phox) from the cytosol to the membranes. Induction of O2 (-) production in H9C2 cardiac myocytes led to the release of a transferable factor able to induce peroxisome proliferator-activated receptor-γ-mediated upregulation of ADIPOQ expression in cocultured EpAT. Using a NOX2 transgenic mouse and a pig model of rapid atrial pacing, we found that oxidation products (such as 4-hydroxynonenal) released from the heart trigger peroxisome proliferator-activated receptor-γ-mediated upregulation of ADIPOQ in EpAT.
conclusionsWe demonstrate for the first time in humans that adiponectin directly decreases myocardial nicotinamide adenine dinucleotide phosphate oxidase activity via endocrine or paracrine effects. Adiponectin expression in EpAT is controlled by paracrine effects of oxidation products released from the heart. These effects constitute a novel defense mechanism of the heart against myocardial oxidative stress.
Indexed as
AdiponectinAdipose TissueAnimalsCell LineFemaleHumansMaleMiceMice, Inbred C57BLMice, TransgenicMyocardiumOrgan Culture TechniquesOxidation-ReductionPericardiumPPAR gammaRatsAdiponectinADIPOQ protein, humanPPAR gammaadiponectinadipose tissuemyocardiumobesityoxidative stress
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