ArticleScientific reports2016
Skeletal muscle alkaline Pi pool is decreased in overweight-to-obese sedentary subjects and relates to mitochondrial capacity and phosphodiester content.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Skeletal muscle mitochondrial impairment in patients with newly diagnosed multiple sclerosis revealed by ¹H/³¹P magnetic resonance spectroscopy.Scientific reports · 2026Observational
- pH-Resolved ATP Synthesis in Skeletal Muscle: Concept, Implementation, and Assessment Using DynamicDiagnostics (Basel, Switzerland) · 2026Article
- Metabolic cost of external work: a novel CPET parameter optimises characterisation of exercise performance in obese individuals.European journal of applied physiology · 2026Article
- Article
- Regionally resolved cardiac metabolism using a dipole-loop array coil for 7 TMagnetic resonance in medicine · 2025Article
- Multiorgan Imaging for Interorgan Crosstalk in Cardiometabolic Diseases.Circulation research · 2025Review
- Increased adiposity is associated with altered skeletal muscle energetics.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Compact MR-compatible ergometer and its application in cardiac MR under exercise stress: A preliminary study.Magnetic resonance in medicine · 2022Article
- Magnetic field therapy enhances muscle mitochondrial bioenergetics and attenuates systemic ceramide levels following ACL reconstruction: Southeast Asian randomized-controlled pilot trial.Journal of orthopaedic translation · 2022Article
- In VitroMolecules (Basel, Switzerland) · 2021Article
- Multinuclear MRS at 7T Uncovers Exercise Driven Differences in Skeletal Muscle Energy Metabolism Between Young and Seniors.Frontiers in physiology · 2020Article
- Magnetic Resonance Imaging of the Musculoskeletal System at 7T: Morphological Imaging and Beyond.Topics in magnetic resonance imaging : TMRI · 2019Review
- Reduced skeletal muscle phosphocreatine concentration in type 2 diabetic patients: a quantitative image-based phosphorus-31 MR spectroscopy study.American journal of physiology. Endocrinology and metabolism · 2018Article
- Differences in Muscle Metabolism Between Triathletes and Normally Active Volunteers Investigated Using Multinuclear Magnetic Resonance Spectroscopy at 7T.Frontiers in physiology · 2018Article
- Skeletal muscle metabolism in rats with low and high intrinsic aerobic capacity: Effect of aging and exercise training.PloS one · 2018Article
- Adiabatic excitation forMagnetic resonance in medicine · 2017Article
- Mitochondrial Function, Obesity, and Personalized Lifestyle Medicine.Integrative medicine (Encinitas, Calif.) · 2017Article
- Article
- In-vivoAnalytical biochemistry · 2017Review
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Authors and funding
12 authors.
Funding
Abstract
Defects in skeletal muscle energy metabolism are indicative of systemic disorders such as obesity or type 2 diabetes. Phosphorus magnetic resonance spectroscopy ((31)P-MRS), in particularly dynamic (31)P-MRS, provides a powerful tool for the non-invasive investigation of muscular oxidative metabolism. The increase in spectral and temporal resolution of (31)P-MRS at ultra high fields (i.e., 7T) uncovers new potential for previously implemented techniques, e.g., saturation transfer (ST) or highly resolved static spectra. In this study, we aimed to investigate the differences in muscle metabolism between overweight-to-obese sedentary (Ob/Sed) and lean active (L/Ac) individuals through dynamic, static, and ST (31)P-MRS at 7T. In addition, as the dynamic (31)P-MRS requires a complex setup and patient exercise, our aim was to identify an alternative technique that might provide a biomarker of oxidative metabolism. The Ob/Sed group exhibited lower mitochondrial capacity, and, in addition, static (31)P-MRS also revealed differences in the Pi-to-ATP exchange flux, the alkaline Pi-pool, and glycero-phosphocholine concentrations between the groups. In addition to these differences, we have identified correlations between dynamically measured oxidative flux and static concentrations of the alkaline Pi-pool and glycero-phosphocholine, suggesting the possibility of using high spectral resolution (31)P-MRS data, acquired at rest, as a marker of oxidative metabolism.
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