Evidence map›Paper›PMID 26838274›Full record

ArticleCritical care (London, England)2016

Assessment of central venous catheter colonization using surveillance culture of withdrawn connectors and insertion site skin.

María Jesús Pérez-Granda, María Guembe, Raquel Cruces, José María Barrio, Emilio Bouza

Registry-linked trialAbstract read
In one paragraph

Article in Critical care (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06216080 (Dynamic Full-Field Optical Coherence Tomography for Structural and Microbiological Characterization of Central Venous Catheter-deposited Biofilm in Critically Ill Patients), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06216080 completednot on this mapstarted 2023, after this paper: background citation

Dynamic Full-Field Optical Coherence Tomography for Structural and Microbiological Characterization of Central Venous Catheter-deposited Biofilm in Critically Ill Patients

TypeobservationalSponsorCentre Hospitalier William Morey - Chalon sur SaôneRan2023 to 2025Enrolled50ConditionsHealthcare Associated Infection, Critically Ill, Central Venous Catheter Associated Bloodstream InfectionArmsD-FF-OCT analysis of CVC
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Unresolved issues in the diagnosis of catheter related candidemia: A position paper.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2024
    Review
  2. Article
  3. Evaluation of the Alfred™ turbidity monitoring system (Alifax®) following sonication in the diagnosis of central venous catheter colonization.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

María Jesús Pérez-GrandaCIBER Enfermedades Respiratorias-CIBERES (CB06/06/0058), Madrid, Spain. massus@hotmail.es.
María GuembeInstituto de Investigación Sanitaria Gregorio Marañón (IISGM), Dr. Esquerdo, 46, 28007, Madrid, Spain. mariaguembe@hotmail.com.
Raquel CrucesInstituto de Investigación Sanitaria Gregorio Marañón (IISGM), Dr. Esquerdo, 46, 28007, Madrid, Spain. rcrufer@gmail.com.
José María BarrioCIBER Enfermedades Respiratorias-CIBERES (CB06/06/0058), Madrid, Spain. jmbarriogut@gmail.com.
Emilio BouzaCIBER Enfermedades Respiratorias-CIBERES (CB06/06/0058), Madrid, Spain. ebouza@microb.net.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCulture of catheter hubs and skin surrounding the catheter entry site has a negative predictive value for catheter tip colonization. However, manipulation of the hub for culture requires the hubs to be swabbed, introducing potential dislodging of biofilm and subsequent migration of microorganisms. Hubs are usually closed with needleless connectors (NCs), which are replaced regularly. Our objective was to evaluate whether culture of flushed withdrawn NCs is an alternative to hub culture when investigating central venous catheter colonization.

methodsThe study population comprised 49 intensive care unit patients whose central venous catheters had been in place for at least 7 days. Cultures of NCs and skin were obtained weekly.

resultsWe included 82 catheters with more than 7 days' indwelling time. The catheter tip colonization rate was 18.3% (15/82). Analysis of skin and NC cultures revealed a 92.5% negative predictive value for catheter colonization. Three episodes of catheter-related bloodstream infection (C-RBSI) occurred in patients with colonized catheters.

conclusionSurveillance of NC and skin cultures could help to identify patients at risk for C-RBSI.

Indexed as

Equipment ContaminationAdultAgedCatheter-Related InfectionsCentral Venous CathetersFemaleHumansInfection ControlIntensive Care UnitsMaleMiddle AgedProspective StudiesSkin

Identifiers

PMID26838274
PMCPMC4736709

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.