ArticleNature communications2016
Diapause is associated with a change in the polarity of secretion of insulin-like peptides.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Host insulin hijacking by a nematode receptor mediates developmental plasticity and sex ratio shifts.Nature communications · 2026Article
- The FMRFamide-like peptide FLP-11 regulates the production and secretion of the TGF-β-like protein DAF-7 during Caenorhabditis elegans larval development.Scientific reports · 2026Article
- Nictation behavior in nematodes.BMC biology · 2025Review
- Gut epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes.Science advances · 2025Article
- The neurohormone tyramine stimulates the secretion of an insulin-like peptide from the Caenorhabditis elegans intestine to modulate the systemic stress response.PLoS biology · 2025Article
- Timing of Diapause Initiation and Overwintering Conditions Alter Gene Expression Profiles inFrontiers in physiology · 2022Article
- Steroid hormone ecdysone deficiency stimulates preparation for photoperiodic reproductive diapause.PLoS genetics · 2021Article
- Article
- Dafachronic acid promotes larval development in Haemonchus contortus by modulating dauer signalling and lipid metabolism.PLoS pathogens · 2019Article
- Rictor/TORC2 mediates gut-to-brain signaling in the regulation of phenotypic plasticity in C. elegans.PLoS genetics · 2018Article
- The Invertebrate Lysozyme Effector ILYS-3 Is Systemically Activated in Response to Danger Signals and Confers Antimicrobial Protection in C. elegans.PLoS pathogens · 2016Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The insulin/IGF-1 signalling (IIS) pathway plays an important role in the regulation of larval diapause, the long-lived growth arrest state called dauer arrest, in Caenorhabditis elegans. In this nematode, 40 insulin-like peptides (ILPs) have been identified as putative ligands of the IIS pathway; however, it remains unknown how ILPs modulate larval diapause. Here we show that the secretory polarity of INS-35 and INS-7, which suppress larval diapause, is changed in the intestinal epithelial cells at larval diapause. These ILPs are secreted from the intestine into the body cavity during larval stages. In contrast, they are secreted into the intestinal lumen and degraded during dauer arrest, only to be secreted into the body cavity again when the worms return to developmental growth. The process that determines the secretory polarity of INS-35 and INS-7, thus, has an important role in the modulation of larval diapause.
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