Evidence map›Paper›PMID 26838027›Full record

ArticleScientific reports2016

Multidisciplinary investigation links backward-speech trait and working memory through genetic mutation.

Stefan Prekovic, Dušica Filipović Đurđević, Gábor Csifcsák, Olivera Šveljo, Oliver Stojković, Milica Janković, Katarina Koprivšek, Laura E Covill, Milos Lučić, Thomas Van den Broeck and 4 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 4 countries.

Stefan PrekovicDepartment of Cellular and Molecular Medicine, Faculty of Medicine, KU Leuven, Leuven, Belgium.
Dušica Filipović ĐurđevićDepartment of Psychology, Faculty of Philosophy, University of Novi Sad, Novi Sad, Serbia.
Gábor CsifcsákInstitute of Psychology, Faculty of Arts, University of Szeged, Szeged, Hungary.
Olivera ŠveljoDiagnostic Imaging Center, Oncology Institute of Vojvodina, Sremska Kamenica, Serbia.
Oliver StojkovićFaculty of Medicine, University of Belgrade, Belgrade, Serbia.
Milica JankovićFaculty of Medicine, University of Belgrade, Belgrade, Serbia.
Katarina KoprivšekDiagnostic Imaging Center, Oncology Institute of Vojvodina, Sremska Kamenica, Serbia.
Laura E CovillWellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK. OX3 7BN.
Milos LučićDiagnostic Imaging Center, Oncology Institute of Vojvodina, Sremska Kamenica, Serbia.
Thomas Van den BroeckDepartment of Cellular and Molecular Medicine, Faculty of Medicine, KU Leuven, Leuven, Belgium.
Christine HelsenDepartment of Cellular and Molecular Medicine, Faculty of Medicine, KU Leuven, Leuven, Belgium.
Fabiola CeroniWellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK. OX3 7BN.
Frank ClaessensDepartment of Cellular and Molecular Medicine, Faculty of Medicine, KU Leuven, Leuven, Belgium.
Dianne F NewburyWellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK. OX3 7BN.
KU Leuven · BEUniversity of Belgrade · RSOncology Institute of Vojvodina · RSUniversity of Oxford · GBCentre for Human Genetics · GBUniversity of Novi Sad · RSUniversity of Szeged · HU

Funding

Medical Research Council G0900747 91070Medical Research Council G1000569Medical Research Council G1000569/1Medical Research Council MR/J003719/1Wellcome TrustWellcome Trust 090532/Z/09/Z
6 · The paper itself

Abstract

Case studies of unusual traits can provide unique snapshots of the effects of modified systems. In this study, we report on an individual from a Serbian family with the ability to rapidly, accurately and voluntarily speak backwards. We consider psychological, neural and genetic correlates of this trait to identify specific relevant neural mechanisms and new molecular pathways for working memory and speech-related tasks. EEG data suggest that the effect of word reversal precedes semantic integration of visually presented backward-words, and that event-related potentials above the frontal lobe are affected by both word reversal and the maintenance of backward-words in working memory. fMRI revealed that the left fusiform gyrus may facilitate the production of backward-speech. Exome sequencing identified three novel coding variants of potential significance in the RIC3, RIPK1 and ZBED5 genes. Taken together, our data suggest that, in this individual, the ability to speak backwards is afforded by an extraordinary working memory capacity. We hypothesise that this is served by cholinergic projections from the basal forebrain to the frontal cortex and supported by visual semantic loops within the left fusiform gyrus and that these neural processes may be mediated by a genetic mutation in RIC3; a chaperone for nicotinic acetylcholine receptors.

Indexed as

MutationQuantitative Trait LociReadingAdultFemaleHumansIntracellular Signaling Peptides and ProteinsMaleMemory, Short-TermMiddle AgedReceptor-Interacting Protein Serine-Threonine KinasesSemanticsSerbiaIntracellular Signaling Peptides and ProteinsReceptor-Interacting Protein Serine-Threonine KinasesRIC3 protein, humanRIPK1 protein, human

Identifiers

PMID26838027
PMCPMC4738289
OpenAlexW2265533382

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.