Evidence map›Paper›PMID 26837951›Full record

ReviewJournal of orthopaedic surgery and research2016

Animal models of osteoarthritis: classification, update, and measurement of outcomes.

Emmanuel L Kuyinu, Ganesh Narayanan, Lakshmi S Nair, Cato T Laurencin

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of orthopaedic surgery and research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 297 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
297citing papers in PubMed, 6 pooled it
40.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

297 citing papers in PubMed, 6 syntheses or guidelines pooled it, 577 citations in OpenAlex.

  1. Pooled it
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  5. Platelet-rich plasma injections induce disease-modifying effects in the treatment of osteoarthritis in animal models.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2021
    Pooled it
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  12. Novel Biomaterial-Based Synovial Fluid Analysis Reveals Protective microRNA Signatures in a Mouse Model of Acute Synovitis-Driven Osteoarthritis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  13. Chondroprotective Effects of Enzyme-Treated Extract fromInternational journal of molecular sciences · 2026
    Article
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237 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Emmanuel L KuyinuInstitute for Regenerative Engineering, University of Connecticut Health, Farmington, CT, USA. kuyinu@uchc.edu.
Ganesh NarayananInstitute for Regenerative Engineering, University of Connecticut Health, Farmington, CT, USA. gnarayanan@uchc.edu.
Lakshmi S NairInstitute for Regenerative Engineering, University of Connecticut Health, Farmington, CT, USA. Nair@uchc.edu.
Cato T LaurencinInstitute for Regenerative Engineering, University of Connecticut Health, Farmington, CT, USA. laurencin@uchc.edu.
UConn Health · US

Funding

Regenerative Engineering of Complex Musculoskeletal Tissues and JointsDP1AR068147 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI LAURENCIN, CATO T. · 2014 to 2018
$4.1M
A Translational Approach Towards Ligament RegenerationR01AR063698 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI LAURENCIN, CATO T. · 2013 to 2018
$1.9M
NIAMS NIH HHS DP1 AR068147NIAMS NIH HHS R01 AR063698
6 · The paper itself

Abstract

Osteoarthritis (OA) is one of the most commonly occurring forms of arthritis in the world today. It is a debilitating chronic illness causing pain and immense discomfort to the affected individual. Significant research is currently ongoing to understand its pathophysiology and develop successful treatment regimens based on this knowledge. Animal models have played a key role in achieving this goal. Animal models currently used to study osteoarthritis can be classified based on the etiology under investigation, primary osteoarthritis, and post-traumatic osteoarthritis, to better clarify the relationship between these models and the pathogenesis of the disease. Non-invasive animal models have shown significant promise in understanding early osteoarthritic changes. Imaging modalities play a pivotal role in understanding the pathogenesis of OA and the correlation with pain. These imaging studies would also allow in vivo surveillance of the disease as a function of time in the animal model. This review summarizes the current understanding of the disease pathogenesis, invasive and non-invasive animal models, imaging modalities, and pain assessment techniques in the animals.

Indexed as

AnimalsArthritis, ExperimentalBiomarkersChronic PainOsteoarthritisTreatment OutcomeBiomarkers

Identifiers

PMID26837951
PMCPMC4738796
OpenAlexW2269139557

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.