ArticleJournal of translational medicine2016
Betel quid dependence is associated with functional connectivity changes of the anterior cingulate cortex: a resting-state fMRI study.
Article in Journal of translational medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Common neural patterns of substance use disorder: a seed-based resting-state functional connectivity meta-analysis.Translational psychiatry · 2025Pooled it
- Brain network dysfunctions in addiction: a meta-analysis of resting-state functional connectivity.Translational psychiatry · 2022Pooled it
- Effect of antidepressants for cessation therapy in betel-quid use disorder: a randomised, double-blind, placebo-controlled trial.Epidemiology and psychiatric sciences · 2020Trial
- Altered Functional Connectivity in the Reward Circuit in Betel Quid-Dependent Chewers.Addiction biology · 2026Article
- Radiomics-based feature exploration and auxiliary diagnostic model construction for gaming disorder.Scientific reports · 2026Article
- The Resting-State Neural Network of Delay Discounting.Frontiers in psychology · 2022Article
- Mapping white matter structural and network alterations in betel quid-dependent chewers using high angular resolution diffusion imaging.Frontiers in psychiatry · 2022Article
- Altered Spontaneous Brain Activity in Betel Quid Dependence Chewers: A Resting-State Functional MRI Study With Percent Amplitude of Fluctuation.Frontiers in psychiatry · 2022Article
- A CNN-Based Autoencoder and Machine Learning Model for Identifying Betel-Quid Chewers Using Functional MRI Features.Brain sciences · 2021Article
- A multivariate pattern analysis of resting-state functional MRI data in Naïve and chronic betel quid chewers.Brain imaging and behavior · 2021Article
- Acute Effect of Betel Quid Chewing on Brain Network Dynamics: A Resting-State Functional Magnetic Resonance Imaging Study.Frontiers in psychiatry · 2021Article
- Altered Topological Organization of Functional Brain Networks in Betel Quid Dependence: A Resting-State Functional MRI Study.Frontiers in psychiatry · 2021Article
- Betel Quid Health Risks of Insulin Resistance Diseases in Poor Young South Asian Native and Immigrant Populations.International journal of environmental research and public health · 2020Review
- Higher Trait Impulsivity and Altered Frontostriatal Connectivity in Betel-Quid Dependent Individuals.Frontiers in human neuroscience · 2020Article
- Acute and Chronic Effects of Betel Quid Chewing on Brain Functional Connectivity.Frontiers in psychiatry · 2020Article
- Structural and Functional Alterations in Betel-Quid Chewers: A Systematic Review of Neuroimaging Findings.Frontiers in psychiatry · 2019Article
- Evaluation of structural connectivity changes in betel-quid chewers using generalized q-sampling MRI.Psychopharmacology · 2017Article
- Disrupted Resting-State Default Mode Network in Betel Quid-Dependent Individuals.Frontiers in psychology · 2017Article
- Altered Brain Functional Connectivity in Betel Quid-Dependent Chewers.Frontiers in psychiatry · 2017Article
- White Matter Integrity Deficit Associated with Betel Quid Dependence.Frontiers in psychiatry · 2017Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIt is generally acknowledged that drug dependence is connected with abnormal functional organization in the individual's brain. The present study aimed to identify the anterior cingulate cortex (ACC) abnormality with the cerebral networks involved in betel quid dependence (BQD) by resting-state functional connectivity (rsFC) using functional magnetic resonance imaging (fMRI).
methodsWith fMRI data measured from 33 resting-state BQD individuals and 32 non-addicted and age-, sex-, education-matched healthy controls, we inquired into the BQD-related changes in FC between the regions of ACC with the whole brain involved in BQD individuals using a region of interest vised method, and to identify the relation of the alteration with the severity of BQD and duration.
resultsCompared to controls, the BQD group showed increased connectivity from ACC to the regions of the reward network (brainstem including midbrain regions such as the ventral tegmental area and pons, caudate, thalamus) and cerebellum. Decreased connectivity was observed in the BQD group in regions from ACC to the default mode network (medial prefrontal cortex and precuneus) and para Hippocampal/hypothalamus. Specifically, the BQD scale was positively correlated with increased FC of right ACC to left thalamus and left ACC to pons; the durations were negatively correlated with FC of right ACC to left precuneus.
conclusionThese disturbances in rsFC from ACC to the reward network and DMN revealed by fMRI may have a key function in providing insights into the neurological pathophysiology underlying BQD-associated executive dysfunction and disinhibition. These findings may contribute to our better understanding of the mechanisms underlying BQD.
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