ReviewNature reviews. Molecular cell biology2016
Do short, frequent DNA sequence motifs mould the epigenome?
Review in Nature reviews. Molecular cell biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- An unbiased approach to measure aberrant DNA methylation alterations.Nature communications · 2026Article
- A roll of the dice: pathogen-host interaction and the evolution of disease susceptibility.Parasitology · 2026Review
- Chromatin-based memory as a self-stabilizing influence on cell identity.Genome biology · 2024Review
- Spatiotemporal DNA methylation dynamics shape megabase-scale methylome landscapes.Life science alliance · 2024Article
- Profound Non-Randomness in Dinucleotide Arrangements within Ultra-Conserved Non-Coding Elements and the Human Genome.Biology · 2023Article
- Article
- DNA methylation-free Arabidopsis reveals crucial roles of DNA methylation in regulating gene expression and development.Nature communications · 2022Article
- Article
- Identification of long regulatory elements in the genome of Plasmodium falciparum and other eukaryotes.PLoS computational biology · 2021Article
- SALL4 controls cell fate in response to DNA base composition.Molecular cell · 2021Article
- Genome-wide DNA Methylation Signatures Are Determined by DNMT3A/B Sequence Preferences.Biochemistry · 2020Article
- Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma.Frontiers in psychiatry · 2019Review
- DNA G-quadruplex structures mold the DNA methylome.Nature structural & molecular biology · 2018Article
- DNA methylation loss in late-replicating domains is linked to mitotic cell division.Nature genetics · 2018Article
- Diversity of cis-regulatory elements associated with auxin response in Arabidopsis thaliana.Journal of experimental botany · 2018Review
- Probing instructions for expression regulation in gene nucleotide compositions.PLoS computational biology · 2018Article
- Binding of high mobility group A proteins to the mammalian genome occurs as a function of AT-content.PLoS genetics · 2017Article
- DNA methylation of intragenic CpG islands depends on their transcriptional activity during differentiation and disease.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Evolutionary mechanism and biological functions of 8-mers containing CG dinucleotide in yeast.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2017Article
- Links between DNA methylation and nucleosome occupancy in the human genome.Epigenetics & chromatin · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
'Epigenome' refers to the panoply of chemical modifications borne by DNA and its associated proteins that locally affect genome function. Epigenomic patterns are thought to be determined by external constraints resulting from development, disease and the environment, but DNA sequence is also a potential influence. We propose that domains of relatively uniform DNA base composition may modulate the epigenome through cell type-specific proteins that recognize short, frequent sequence motifs. Differential recruitment of epigenomic modifiers may adjust gene expression in multigene blocks as an alternative to tuning the activity of each gene separately, thus simplifying gene expression programming.
Indexed as
Identifiers
26837845What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.