Evidence map›Paper›PMID 26837741›Full record

ArticleCirculation research2016

Most of the Dust Has Settled: cKit+ Progenitor Cells Are an Irrelevant Source of Cardiac Myocytes In Vivo.

Jop H van Berlo, Jeffery D Molkentin

Abstract read
In one paragraph

Article in Circulation research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Review
  6. Cardiac Cell Therapy: Insights into the Mechanisms of Tissue Repair.International journal of molecular sciences · 2021
    Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Abcg2-expressing side population cells contribute to cardiomyocyte renewal through fusion.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
  12. Review
  13. Review
  14. Function Follows Form - A Review of Cardiac Cell Therapy.Circulation journal : official journal of the Japanese Circulation Society · 2019
    Review
  15. Review
  16. Multipotent fetal-derived Cdx2 cells from placenta regenerate the heart.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  17. Article
  18. Role of c-Kit in Myocardial Regeneration and Aging.Frontiers in endocrinology · 2019
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jop H van BerloFrom the Lillehei Heart Institute, Department of Medicine, University of Minnesota, Minneapolis (J.H.v.B.); Department of Pediatrics, Cincinnati Children's Hospital Medical Center, OH (J.D.M.); and Howard Hughes Medical Institute, Cincinnati, OH (J.D.M.). jeff.molkentin@cchmc.org jvanberl@umn.edu.
Jeffery D MolkentinFrom the Lillehei Heart Institute, Department of Medicine, University of Minnesota, Minneapolis (J.H.v.B.); Department of Pediatrics, Cincinnati Children's Hospital Medical Center, OH (J.D.M.); and Howard Hughes Medical Institute, Cincinnati, OH (J.D.M.). jeff.molkentin@cchmc.org jvanberl@umn.edu.

Funding

MOLECULAR PATHWAYS CONTROLLING CARDIAC GENE EXPRESSIONR01HL060562 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI MOLKENTIN, JEFFERY D · 1998 to 2021
$4.1M
Strategic activation of endogenous c-kit+ progenitor cells for cardiac regenerationR01HL130072 · NHLBI · UNIVERSITY OF MINNESOTA · PI VAN BERLO, JOHANNES (JOP) · 2016 to 2020
$1.9M
Functional relevance of cardiac regeneration by c-kit positive stem cellsR00HL112852 · NHLBI · UNIVERSITY OF MINNESOTA · PI VAN BERLO, JOHANNES (JOP) · 2013 to 2015
$712k
Howard Hughes Medical InstituteNHLBI NIH HHS R00 HL112852NHLBI NIH HHS R01 HL060562NHLBI NIH HHS R01 HL130072
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsHeartHumansMyocytes, CardiacProto-Oncogene Proteins c-kitRegenerationStem CellsProto-Oncogene Proteins c-kit

Identifiers

PMID26837741
PMCPMC6329000

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.