ArticleSaudi medical journal2016
Ki67 expression in breast cancer. Correlation with prognostic markers and clinicopathological parameters in Saudi patients.
Article in Saudi medical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- A retrospective analysis of clinicopathological characteristics and risk factors for recurrence in young patients with breast cancer.Gland surgery · 2024Article
- The epidemiological and clinicopathological features of breast cancer in Riyadh, Saudi Arabia.Saudi medical journal · 2024Article
- Review
- Article
- Clinicopathological and prognostic value of Ki-67 expression in oral malignant melanoma: A systematic review and meta-analysis.Journal of dental research, dental clinics, dental prospects · 2022Review
- The correlation ofClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2021Article
- Correlation of prognostic and predictive indicators in breast cancer patients from the eastern province of Saudi Arabia.Saudi medical journal · 2021Article
- Proteomics and its applications in breast cancer.American journal of cancer research · 2021Review
- Potential roles of lymphovascular space invasion based on tumor characteristics provide important prognostic information in T1 tumors with ER and HER2 positive breast cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2020Observational
- Prediction model of lymphovascular invasion based on clinicopathological factors in Chinese patients with invasive breast cancer.Medicine · 2018Article
- [Metastatic breast cancer in the spine : Molecular predictors for choosing adequate treatment strategies].Der Orthopade · 2018Review
- Proliferative Index (Ki67) for Prediction in Breast Duct CarcinomasAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Predictors of lymphovascular invasion identified from pathological factors in Chinese patients with breast cancer.Oncotarget · 2018Article
- Comparative study of Her-2, p53, Ki-67 expression and clinicopathological characteristics of breast cancer in a cohort of northern China female patients.Bioengineered · 2017Article
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6 authors.
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Abstract
objectivesTo evaluate Ki67 immunoexpression pattern in Saudi breast cancer (BC) patients and investigate any possible predictive or prognostic value for Ki67.
methodsThis is a retrospective study designed to quantitatively assess the Ki67 proliferative index (PI) in retrieved paraffin blocks of 115 Saudi BC patients diagnosed between January 2005 and March 2015 at the Department of Pathology, King Fahd Hospital, Al Madinah Al Munawarah, Kingdom of Saudi Arabia. The Ki67 PI was correlated with individual and combined immunoprofile data of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2/neu) with their clinicopathological parameters.
resultsKi67 immunoreactivity was highly expressed (greater than 25% of the tumor cells were positive) in 85 (73.9%) patients. The Ki67 PI was significantly associated with poor prognostic clinicopathological parameters including old age (p less than 0.02), high tumor grade (p less than 0.01), lymph node metastasis (p less than 0.001), and Her-2/neu positivity (p less than 0.009). However, the association with ER positivity, PR positivity, tumor size, and lymphovascular invasion were not statistically significant. The Ki67 PI was significantly associated with BC molecular subtypes that were Her2/neu positive (luminal B and HER-2) subtypes compared with the Her2/neu negative (luminal A) subtype (p less than 0.04).
conclusionThe Ki67 PI is significantly higher in Saudi BC patients comparing with the reported literature. Ki67 PI was highest in the HER-2 and luminal-B molecular subtypes. Along with other prognostic indicators, Ki67 PI may be useful in predicting prognosis and management of Saudi BC patients.
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