Evidence map›Paper›PMID 26836934›Full record

ArticleChest2016

Association Between Occupational Exposures and Sarcoidosis: An Analysis From Death Certificates in the United States, 1988-1999.

Hongbo Liu, Divya Patel, Alison M Welch, Carla Wilson, Margaret M Mroz, Li Li, Cecile S Rose, Michael Van Dyke, Jeffrey J Swigris, Nabeel Hamzeh and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Chest, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 73 citations in OpenAlex.

  1. Particles exposures and sarcoidosis.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Sarcoidosis and burn pit exposure in military deployers to Iraq, Afghanistan, and Southwest Asia.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2023
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Sarcoidosis in Northern Ontario hard-rock miners: A case series.American journal of industrial medicine · 2022
    Article
  13. Review
  14. Article
  15. Review
  16. Sarcoidosis: a prospective observational cohort from Northern Alberta.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2020
    Article
  17. Review
  18. Review
  19. Article
  20. A Novel In Vitro Human Granuloma Model of Sarcoidosis and Latent Tuberculosis Infection.American journal of respiratory cell and molecular biology · 2017
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Hongbo LiuDivision of Environmental and Occupational Health Sciences, National Jewish Health, Denver, CO; Department of Epidemiology and Biostatistics, China Medical University, Shenyang, China.
Divya PatelDivision of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Gainesville, FL.
Alison M WelchDivision of Environmental and Occupational Health Sciences, National Jewish Health, Denver, CO.
Carla WilsonDepartment of Biostatistics, National Jewish Health, Denver, CO.
Margaret M MrozDivision of Environmental and Occupational Health Sciences, National Jewish Health, Denver, CO.
Li LiDivision of Environmental and Occupational Health Sciences, National Jewish Health, Denver, CO; Division of Pulmonary and Critical Care Sciences, Colorado School of Public Health, University of Colorado, Aurora, CO.
Cecile S RoseDivision of Environmental and Occupational Health Sciences, National Jewish Health, Denver, CO; Division of Pulmonary and Critical Care Sciences, Colorado School of Public Health, University of Colorado, Aurora, CO; School of Medicine, and Environmental and Occupational Health, Colorado School of Public Health, University of Colorado, Aurora, CO.
Michael Van DykeSchool of Medicine, and Environmental and Occupational Health, Colorado School of Public Health, University of Colorado, Aurora, CO.
Jeffrey J SwigrisPulmonary Division, National Jewish Health, Denver, CO; Division of Pulmonary and Critical Care Sciences, Colorado School of Public Health, University of Colorado, Aurora, CO.
Nabeel HamzehDivision of Environmental and Occupational Health Sciences, National Jewish Health, Denver, CO; Division of Pulmonary and Critical Care Sciences, Colorado School of Public Health, University of Colorado, Aurora, CO.
Lisa A MaierDivision of Environmental and Occupational Health Sciences, National Jewish Health, Denver, CO; Division of Pulmonary and Critical Care Sciences, Colorado School of Public Health, University of Colorado, Aurora, CO; School of Medicine, and Environmental and Occupational Health, Colorado School of Public Health, University of Colorado, Aurora, CO. Electronic address: maierl@njhealth.org.
Colorado School of Public Health · USNational Jewish Health · USUniversity of Colorado Denver · USChina Medical University · CNUniversity of Florida · US

Funding

Genetic Risk for Granulomatous Interstitial Lung DiseaseR01HL114587 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI FINGERLIN, TASHA E. · 2013 to 2018
$3.2M
Immunologic and Molecular Phenotypes in AATD and SarcoidosisU01HL112695 · NHLBI · NATIONAL JEWISH HEALTH · PI MAIER, LISA A · 2012 to 2014
$465k
NHLBI NIH HHS R01 HL114587NHLBI NIH HHS U01 HL112695
6 · The paper itself

Abstract

backgroundSarcoidosis is a disease that is associated with occupational and environmental antigens, in the setting of a susceptible host. The aim of this study was to examine the association between sarcoidosis mortality and previously reported occupational exposures based on sex and race.

methodsThe decedents enrolled in this study were derived from United States death certificates from 1988-1999. Cause of death was coded according to ICD-9 and ICD-10. The usual occupation was coded with Bureau of the Census Occupation Codes. Mortality odds ratio (MOR) were determined and multiple Poisson regression were performed to evaluate the independent exposure effects after adjustment for age, sex, race and other occupational exposures.

resultsOf the 7,118,535 decedents in our study, 3,393 were identified as sarcoidosis-related, including 1,579 identified as sarcoidosis being the underlying cause of death. The sarcoidosis-related MOR of any occupational exposure was 1.52 (95% CI, 1.35-1.71). Women with any exposure demonstrated an increased MOR compared to women without (MOR 1.65, 95% CI, 1.45-1.89). The mortality risk was significantly elevated in those with employment involving metal working, health care, teaching, sales, banking, and administration. Higher sarcoidosis-related mortality risks associated with specific exposures were noted in women vs men and blacks vs whites.

conclusionsFindings of prior occupations and risk of sarcoidosis were verified using sarcoidosis mortality rates. There were significant differences in risk for sarcoidosis mortality by occupational exposures based on sex and race.

Indexed as

AdolescentAdultAgedBanking, PersonalBlack or African AmericanCause of DeathCommerceDeath CertificatesFemaleHealth Care SectorHumansInternational Classification of DiseasesMaleMetalsMiddle AgedMortalityMetalsmortalitymortality ORoccupational exposuresarcoidosis

Identifiers

PMID26836934
PMCPMC4980546
OpenAlexW2267588446

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.