ArticleChest2016
Validity of Fractional Exhaled Nitric Oxide in Diagnosis of Corticosteroid-Responsive Cough.
Article in Chest, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04885738 (The Value of Exhaled Nitric Oxide in Predicting Airway Eosinophilic Inflammation in Chronic Airway Inflammatory Disease), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Value of Exhaled Nitric Oxide in Predicting Airway Eosinophilic Inflammation in Chronic Airway Inflammatory Disease
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Performance of fractional exhaled nitric oxide in predicting response to inhaled corticosteroids in chronic cough: a meta-analysis.Annals of medicine · 2021Pooled it
- Effects of treatment with montelukast alone, budesonide/formoterol alone and a combination of both in cough variant asthma.Respiratory research · 2022Trial
- Fractional exhaled nitric oxide at multiple flow rates in chronic cough: association with lung function and airway hyperresponsiveness.Annals of medicine · 2026Article
- Article
- How to quickly determine whether patients with chronic cough need corticosteroid treatment--construction of a predictive model for corticosteroid-responsive cough in chronic cough.NPJ primary care respiratory medicine · 2026Article
- Long-term nitric oxide exposure induces cough hypersensitivity via non-inflammatory activation of the HIF1α-TRPV1 pathway.Frontiers in pharmacology · 2026Article
- Is fractional exhaled nitric oxide a treatable trait in chronic cough: a narrative review.Journal of thoracic disease · 2023Review
- Diagnostic accuracy of blood eosinophils in comparison to other common biomarkers for identifying sputum eosinophilia in patients with chronic cough.The World Allergy Organization journal · 2023Article
- Article
- [History of atopy reduces predictive value of fractional exhaled nitric oxide for eosinophilic airway inflammation in chronic cough].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022Article
- Prediction of bronchodilation test in adults with chronic cough suspected of cough variant asthma.Frontiers in medicine · 2022Article
- Mechanisms and Rationale for Targeted Therapies in Refractory and Unexplained Chronic Cough.Clinical pharmacology and therapeutics · 2021Review
- Small Airway Dysfunction in Cough Variant Asthma: Prevalence, Clinical, and Pathophysiological Features.Frontiers in physiology · 2021Article
- Diagnostic Value of Fractional Exhaled Nitric Oxide and Small Airway Function in Differentiating Cough-Variant Asthma from Typical Asthma.Canadian respiratory journal · 2021Article
- 2019 ERS cough guideline: consensus and controversy.Journal of thoracic disease · 2020Article
- Perspectives on chronic cough in Korea.Journal of thoracic disease · 2020Review
- Elevated Circulating CD4Lung · 2020Article
- Review
- Value of Exhaled Nitric Oxide and FEFAllergy, asthma & immunology research · 2019Article
- Age and Sex Distribution of Chinese Chronic Cough Patients and Their Relationship With Capsaicin Cough Sensitivity.Allergy, asthma & immunology research · 2019Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhether fractional exhaled nitric oxide (FeNO) measurement alone or combined with sputum eosinophil and atopy is useful in predicting corticosteroid-responsive cough (CRC) and non-CRC (NCRC) is not clear.
methodsA total of 244 patients with chronic cough and 59 healthy subjects as control were enrolled. The causes of chronic cough were confirmed according to a well-established diagnostic algorithm. FeNO measurement and induced sputum for differential cell were performed in all subjects.
resultsCRC occurred in 139 (57.0%) patients and NCRC occurred in 105. The FeNO level in CRC significantly correlated with sputum eosinophils (rs = 0.583, P < .01). The median (quarter) of FeNO level in CRC was significantly higher than NCRC (32.0 ppb [19.0-65.0 ppb] vs 15.0 ppb [11.0-22.0 ppb], P < .01). FeNO of 31.5 ppb had a sensitivity and specificity of 54.0% and 91.4%, respectively, in predicting CRC from chronic cough, with a positive predictive value of 89.3% and a negative predictive value of 60.0%. If the patients had a combination of low level of FeNO ( < 22.5 ppb), normal sputum eosinophil ( < 2.5%), and absence of atopy, the sensitivity and specificity would be 30.3% and 93.5% for predicting NCRC.
conclusionsIn our cohort, a high level (≥ 31.5 ppb) of FeNO indicates more likelihood of CRC, but the sensitivity is insufficient to rule out a diagnosis of CRC. A combination of low-level FeNO, normal sputum eosinophil, and absence of atopy suggests a lower likelihood of CRC.
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