Evidence map›Paper›PMID 26836895›Full record

ArticleChest2016

Age-Related Differences in Health-Related Quality of Life in COPD: An Analysis of the COPDGene and SPIROMICS Cohorts.

Carlos H Martinez, Alejandro A Diaz, Amit D Parulekar, Stephen I Rennard, Richard E Kanner, Nadia N Hansel, David Couper, Kristen E Holm, Karin F Hoth, Jeffrey L Curtis and 7 more

2 registry-linked trialsOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chest, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00608764 active not recruitingnot on this map

Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPDGene)

TypeobservationalSponsorBrigham and Women's HospitalRan2007 to 2028Enrolled10,718ConditionsPulmonary Disease, Chronic Obstructive, Emphysema, Bronchitis, Chronic
NCT01969344 active not recruitingnot on this map

Subpopulations and Intermediate Outcome Measures in COPD Study

TypeobservationalSponsorUniversity of North Carolina, Chapel HillRan2010 to 2031Enrolled2,981ConditionsCOPD, Chronic Obstructive Pulmonary Disease, Chronic Bronchitis, Emphysema
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 12 institutions in 1 country.

Carlos H MartinezDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI. Electronic address: carlosma@umich.edu.
Alejandro A DiazDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Amit D ParulekarSection of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX.
Stephen I RennardDivision of Pulmonary and Critical Care Medicine, University of Nebraska, Omaha, NE.
Richard E KannerUniversity of Utah, Salt Lake City, UT.
Nadia N HanselJohns Hopkins University, Baltimore, MD.
David CouperUniversity of North Carolina at Chapel Hill, Chapel Hill, NC.
Kristen E HolmNational Jewish Health, Denver, CO; School of Public Health, University of Colorado, Aurora, CO.
Karin F HothDepartment of Psychiatry, University of Iowa, Iowa City, IA.
Jeffrey L CurtisDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI; VA Ann Arbor Healthcare System, Ann Arbor, MI.
Fernando J MartinezDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI.
Nicola A HananiaSection of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX.
Elizabeth A ReganNational Jewish Health, Denver, CO; University of Colorado, Denver, CO.
Robert PaineUniversity of Utah, Salt Lake City, UT; VA Salt Lake City, Salt Lake City, UT.
Christine T CigolleDepartment of Family Medicine, University of Michigan, Ann Arbor, MI; VA Ann Arbor Healthcare System, Ann Arbor, MI.
MeiLan K HanDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI.
COPDGene and SPIROMICS Investigators
University of Michigan–Ann Arbor · USBaylor College of Medicine · USVA Ann Arbor Healthcare System · USBrigham and Women's Hospital · USJohns Hopkins University · USNational Jewish Health · USUniversity of Colorado Denver · USUniversity of Iowa · USUniversity of Nebraska at Omaha · USUniversity of North Carolina at Chapel Hill · USUniversity of Utah · USVA Salt Lake City Healthcare System · US

Funding

Metabolomic signatures of empysema and COPD progression in the COPDGene cohortR01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2012 to 2016
$31.1M
(2 of 2) Genetic Epidemiology of COPDR01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2012 to 2016
$18.9M
Parametric Response Mapping in COPDR01HL122438 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAN, MEILAN K, MARTINEZ, FERNANDO J · 2014 to 2017
$4.0M
Computed Tomographic-Based Assessment of Airway Remodeling in COPDK01HL118714 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DIAZ, ALEJANDRO · 2013 to 2017
$783k
Cardiopulmonary Mechanisms Affecting Cognition in COPDK23HL095658 · NHLBI · UNIVERSITY OF IOWA · PI HOTH, KARIN F · 2010 to 2014
$747k
Geriatric Conditions and Disablement in the Older Adult PopulationK08AG031837 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CIGOLLE, CHRISTINE T · 2010 to 2014
$639k
Personalizing COPD therapies by exploring heterogeneity of treatment effectsK23HL128936 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MARTINEZ, CARLOS H · 2016 to 2017
$249k
NHLBI NIH HHS 3R01HL122438-02S1NHLBI NIH HHS HHSN268200900013CNHLBI NIH HHS HHSN268200900014CNHLBI NIH HHS HHSN268200900015CNHLBI NIH HHS HHSN268200900016CNHLBI NIH HHS HHSN268200900017CNHLBI NIH HHS HHSN268200900018CNHLBI NIH HHS HHSN268200900019CNHLBI NIH HHS HHSN268200900020CNHLBI NIH HHS K01 HL118714NHLBI NIH HHS K01HL118714NHLBI NIH HHS K23 HL095658NHLBI NIH HHS K23 HL128936NHLBI NIH HHS R01 HL089856NHLBI NIH HHS R01 HL089897NHLBI NIH HHS R01 HL122438NIA NIH HHS K08 AG031837WHI NIH HHS HHSN268200900009C
6 · The paper itself

Abstract

objectiveYounger persons with COPD report worse health-related quality of life (HRQL) than do older individuals. The factors explaining these differences remain unclear. The objective of this article was to explore factors associated with age-related differences in HRQL in COPD.

methodsCross-sectional analysis of participants with COPD, any Global Initiative for Chronic Obstructive Lung Disease grade of airflow limitation, and ≥ 50 years old in two cohorts: the Genetic Epidemiology of COPD (COPDGene) study and the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS). We compared St. George's Respiratory Questionnaire (SGRQ) scores by age group: middle-aged (age, 50-64) vs older (age, 65-80) adults. We used multivariate linear modeling to test associations of age with HRQL, adjusting for demographic and clinical characteristics and comorbidities.

resultsAmong 4,097 participants in the COPDGene study (2,170 middle-aged and 1,927 older adults) SGRQ total scores were higher (worse) among middle-aged (mean difference, -4.2 points; 95% CI, -5.7 to -2.6; P < .001) than older adults. Age had a statistically significant interaction with dyspnea (P < .001). Greater dyspnea severity (modified Medical Research Council ≥ 2, compared with 0-1) had a stronger association with SGRQ score among middle-aged (β, 24.6; 95% CI, 23.2-25.9) than older-adult (β, 21.0; 95% CI, 19.6-22.3) participants. In analyses using SGRQ as outcome in 1,522 participants in SPIROMICS (598 middle-aged and 924 older adults), we found similar associations, confirming that for the same severity of dyspnea there is a stronger association with HRQL among younger individuals.

conclusionsAge-related differences in HRQL may be explained by a higher impact of dyspnea among younger subjects with COPD. TRIAL REGISTRY: ClinicalTrials.gov; No.: NCT00608764 and No.: NCT01969344; URL: www.clinicaltrials.gov.

Indexed as

Health StatusQuality of LifeAgedAge FactorsCohort StudiesCross-Sectional StudiesDyspneaFemaleHumansMaleMiddle AgedPulmonary Disease, Chronic ObstructiveagingCOPDdyspneageriatricshealth statusobstructive lung diseasequality of life

Identifiers

PMID26836895
PMCPMC4944781
OpenAlexW2225744503

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.