ArticleNature communications2016
Unique features of a global human ectoparasite identified through sequencing of the bed bug genome.
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Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.
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105citing papers in PubMed
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Who cites it
105 citing papers in PubMed.
- Genome sequencing and multi-stage, blood-feeding, and tissue-specific transcriptome atlas of the Rocky Mountain wood tick provide a critical resource for this vector.Insect biochemistry and molecular biology · 2026Article
- Genome sequencing and multi-stage, blood-feeding, and tissue-specific transcriptome atlas of the Rocky Mountain wood tick provide a critical resource for this vector.bioRxiv : the preprint server for biology · 2026Article
- Bed bug preferences for host odor or aggregation odor are differentially modulated by physiological state in various odorscapes.Pest management science · 2026Article
- Intraspecific microbiome dynamics across the life cycle of the milkweed bugMicrobial genomics · 2026Article
- Article
- Gut bacteria induce heterologous immune priming in Rhodnius prolixus encompassing both humoral and cellular immune responses.PLoS pathogens · 2025Article
- Chromosome-scale genome assembly of the bed bug Cimex lectularius sheds light on a key insecticide resistance locus.G3 (Bethesda, Md.) · 2025Article
- Characterization of odorant binding and chemosensory protein families in the kissing bug Triatoma infestans: comparative analysis among Heteroptera species.BMC genomics · 2025Article
- Functionality of highly diverged Imd like genes identified in stinkbugs and bedbugs.Scientific reports · 2025Article
- Evolutionary Convergence of Nutritional Symbionts in Ticks.Environmental microbiology reports · 2025Article
- ArtSymbioCyc, a metabolic network database collection dedicated to arthropod symbioses: a case study, the tripartite cooperation inmSystems · 2025Article
- Know Where You Go: Infestation Dynamics and Potential Distribution of Two Bed Bug Species (Hemiptera: Cimicidae) in Africa.Insects · 2025Article
- Article
- Deployment and transcriptional evaluation of nitisinone, an FDA-approved drug, to control bed bugs.Pest management science · 2025Article
- Genome of tropical bed bug Cimex hemipterus (Cimicidae, Hemiptera) reveals tetraspanin expanded in bed bug ancestor.Insect science · 2025Article
- Common Bed Bugs: Non-Viable Hosts forCells · 2024Article
- Genome-Wide Search for Gene Mutations Likely Conferring Insecticide Resistance in the Common Bed Bug,Insects · 2024Article
- A novel prolixicin identified in common bed bugs with activity against both bacteria and parasites.Scientific reports · 2024Article
- The puncture mechanics: an example from the bed bugJournal of the Royal Society, Interface · 2024Article
- Identification of the pan-allergen tropomyosin from the common bed bug (Cimex lectularius).Scientific reports · 2024Article
45 more citing papers are in PubMed but not listed here.
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Authors and funding
81 authors.
Joshua B BenoitDepartment of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221, USA.
Zach N AdelmanFralin Life Science Institute and Department of Entomology, Virginia Tech, Blacksburg, Virginia 24061, USA.
Klaus ReinhardtDepartment of Biology, Applied Zoology, Technische Universitaet Dresden, Dresden 01062, Germany.
Amanda DolanDepartment of Biology, University of Rochester, Rochester, New York 14627, USA.
Monica PoelchauNational Agricultural Library, Beltsville, Maryland 20705, USA.
Emily C JenningsDepartment of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221, USA.
Elise M SzuterDepartment of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221, USA.
Richard W HaganDepartment of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221, USA.
Hemant GujarDepartment of Entomology, University of Kentucky, Lexington, Kentucky 40546, USA.
Jayendra Nath ShuklaDepartment of Entomology, University of Kentucky, Lexington, Kentucky 40546, USA.
Fang ZhuDepartment of Entomology, University of Kentucky, Lexington, Kentucky 40546, USA.
M MohanICAR-National Bureau of Agricultural Insect Resources, Indian Council of Agricultural Research, Bengaluru 560024, India.
David R NelsonDepartment of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Sciences Center, Memphis, Tennessee 38163, USA.
Andrew J RosendaleDepartment of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221, USA.
Christian DerstCologne Biocenter and Zoological Institute, University of Cologne, Cologne 50674, Germany.
Valentina ResnikInstitut für Bienenkunde (Polytechnische Gesellschaft), Goethe University Frankfurt, Oberursel 61440, Germany.
Sebastian WernigInstitut für Bienenkunde (Polytechnische Gesellschaft), Goethe University Frankfurt, Oberursel 61440, Germany.
Pamela MenegazziDepartment of Neurobiology and Genetics, Theodor-Boveri-Institute, Biocenter, University of Würzburg, Würzburg 97074, Germany.
Christian WegenerDepartment of Neurobiology and Genetics, Theodor-Boveri-Institute, Biocenter, University of Würzburg, Würzburg 97074, Germany.ORCID http://orcid.org/0000-0003-4481-3567
Nicolai PeschelDepartment of Neurobiology and Genetics, Theodor-Boveri-Institute, Biocenter, University of Würzburg, Würzburg 97074, Germany.
Jacob M HendershotDepartment of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221, USA.
Wolfgang BlenauCologne Biocenter and Zoological Institute, University of Cologne, Cologne 50674, Germany.
Reinhard PredelCologne Biocenter and Zoological Institute, University of Cologne, Cologne 50674, Germany.
Paul R JohnstonDepartment of Evolutionary Biology, Institute of Biology, Freie Universitaet, Berlin 14195, Germany.ORCID http://orcid.org/0000-0002-8651-4488
Panagiotis IoannidisDepartment of Genetic Medicine and Development and Swiss Institute of Bioinformatics, University of Geneva, Geneva 1211, Switzerland.ORCID http://orcid.org/0000-0003-0939-6745
Robert M WaterhouseDepartment of Genetic Medicine and Development and Swiss Institute of Bioinformatics, University of Geneva, Geneva 1211, Switzerland.ORCID http://orcid.org/0000-0003-4199-9052
Ralf NauenPest Control Biology and Research Technologies, Bayer CropScience AG, Monheim 40789, Germany.
Corinna SchornPest Control Biology and Research Technologies, Bayer CropScience AG, Monheim 40789, Germany.
Mark-Christoph OttPest Control Biology and Research Technologies, Bayer CropScience AG, Monheim 40789, Germany.
Frank MaiwaldPest Control Biology and Research Technologies, Bayer CropScience AG, Monheim 40789, Germany.
J Spencer JohnstonDepartment of Entomology, Texas A&M University, College Station, Texas 77843, USA.
Ameya D GondhalekarDepartment of Entomology, Purdue University, West Lafayette, Indiana 47907, USA.
Michael E ScharfDepartment of Entomology, Purdue University, West Lafayette, Indiana 47907, USA.
Brittany F PetersonDepartment of Entomology, Purdue University, West Lafayette, Indiana 47907, USA.
Kapil R RajeDepartment of Entomology, Purdue University, West Lafayette, Indiana 47907, USA.
Benjamin A HottelDepartment of Entomology and Nematology, University of Florida, Gainesville, Florida 32611, USA.
David ArmisénInstitue de Génomique Fonctionnelle de Lyon (IGFL), Ecole Normale Supérieure de Lyon, UMR5242-CNRS, Lyon 69007, France.
Antonin Jean Johan CrumièreInstitue de Génomique Fonctionnelle de Lyon (IGFL), Ecole Normale Supérieure de Lyon, UMR5242-CNRS, Lyon 69007, France.
Peter Nagui RefkiInstitue de Génomique Fonctionnelle de Lyon (IGFL), Ecole Normale Supérieure de Lyon, UMR5242-CNRS, Lyon 69007, France.
Maria Emilia SantosInstitue de Génomique Fonctionnelle de Lyon (IGFL), Ecole Normale Supérieure de Lyon, UMR5242-CNRS, Lyon 69007, France.
Essia SghaierInstitue de Génomique Fonctionnelle de Lyon (IGFL), Ecole Normale Supérieure de Lyon, UMR5242-CNRS, Lyon 69007, France.
Sèverine VialaInstitue de Génomique Fonctionnelle de Lyon (IGFL), Ecole Normale Supérieure de Lyon, UMR5242-CNRS, Lyon 69007, France.
Abderrahman KhilaInstitue de Génomique Fonctionnelle de Lyon (IGFL), Ecole Normale Supérieure de Lyon, UMR5242-CNRS, Lyon 69007, France.
Seung-Joon AhnDepartment of Entomology, Max Planck Institute for Chemical Ecology, Jena 07745, Germany.
Christopher ChildersNational Agricultural Library, Beltsville, Maryland 20705, USA.ORCID http://orcid.org/0000-0002-1253-5550
Chien-Yueh LeeNational Agricultural Library, Beltsville, Maryland 20705, USA.
Han LinNational Agricultural Library, Beltsville, Maryland 20705, USA.ORCID http://orcid.org/0000-0002-3446-5098
Daniel S T HughesHuman Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
Elizabeth J DuncanDepartment of Biochemistry and Genetics Otago, University of Otago, Dunedin 9054, New Zealand.
Shwetha C MuraliHuman Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
Jiaxin QuHuman Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
Shannon DuganHuman Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
Sandra L LeeHuman Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
Hsu ChaoHuman Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
Huyen DinhHuman Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
Yi HanHuman Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
Harshavardhan DoddapaneniHuman Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
Kim C WorleyHuman Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
Donna M MuznyHuman Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
David WheelerInstitute of Fundamental Science, Massey University, Palmerston North 4442, New Zealand.
Kristen A PanfilioInstitute for Developmental Biology, University of Cologne, Cologne 50674, Germany.
Iris M Vargas JentzschInstitute for Developmental Biology, University of Cologne, Cologne 50674, Germany.
Edward L VargoDepartment of Entomology, Texas A&M University, College Station, Texas 77843, USA.
Warren BoothDepartment of Biological Sciences, University of Tulsa, Tulsa, Oklahoma 74104, USA.ORCID http://orcid.org/0000-0003-2355-0702
Markus FriedrichDepartment of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA.
Matthew T WeirauchCenter for Autoimmune Genomics and Etiology, Division of Biomedical Informatics, and Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA.
Michelle A E AndersonFralin Life Science Institute and Department of Entomology, Virginia Tech, Blacksburg, Virginia 24061, USA.
Jeffery W JonesDepartment of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA.
Omprakash MittapalliDepartment of Entomology, The Ohio State University, Wooster, Ohio 44691, USA.
Chaoyang ZhaoDepartment of Entomology, The Ohio State University, Wooster, Ohio 44691, USA.
Jing-Jiang ZhouDepartment of Biological Chemistry and Crop Protection, Rothamsted Research, BBSRC Harpenden, Herts AL5 2JQ, UK.
Jay D EvansUnited States Department of Agriculture-Agricultural Research Service Bee Research Laboratory, Beltsville, Maryland 20705, USA.ORCID http://orcid.org/0000-0002-0036-4651
Geoffrey M AttardoDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, Connecticut 06520, USA.
Hugh M RobertsonDepartment of Entomology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
Evgeny M ZdobnovDepartment of Genetic Medicine and Development and Swiss Institute of Bioinformatics, University of Geneva, Geneva 1211, Switzerland.
Jose M C RibeiroLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, Bethesda, Maryland 20892, USA.
Richard A GibbsHuman Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
John H WerrenDepartment of Biology, University of Rochester, Rochester, New York 14627, USA.
Subba R PalliDepartment of Entomology, University of Kentucky, Lexington, Kentucky 40546, USA.
Coby SchalDepartment of Entomology and W.M. Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina 27695, USA.
Stephen RichardsHuman Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
Funding
The Human Genome Sequencing CenterU54HG003273 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI GIBBS, RICHARD A · 2004 to 2015
$341.3MUsing social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2MVector-Borne Diseases: Biology Of Vector Host RelationshipZIAAI000810 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI RIBEIRO, JOSE · 2009 to 2025
$20.8MMolecular Analysis of Juvenile Hormone ActionR01GM070559 · NIGMS · UNIVERSITY OF KENTUCKY · PI PALLI, SUBBA R · 2005 to 2024
$4.1MEuropean Research Council 260986European Research Council 616346NCATS NIH HHS UL1 TR001427NHGRI NIH HHS U54 HG003273NIGMS NIH HHS GM070559-9NIGMS NIH HHS R01 GM070559
Abstract
The bed bug, Cimex lectularius, has re-established itself as a ubiquitous human ectoparasite throughout much of the world during the past two decades. This global resurgence is likely linked to increased international travel and commerce in addition to widespread insecticide resistance. Analyses of the C. lectularius sequenced genome (650 Mb) and 14,220 predicted protein-coding genes provide a comprehensive representation of genes that are linked to traumatic insemination, a reduced chemosensory repertoire of genes related to obligate hematophagy, host-symbiont interactions, and several mechanisms of insecticide resistance. In addition, we document the presence of multiple putative lateral gene transfer events. Genome sequencing and annotation establish a solid foundation for future research on mechanisms of insecticide resistance, human-bed bug and symbiont-bed bug associations, and unique features of bed bug biology that contribute to the unprecedented success of C. lectularius as a human ectoparasite.
Indexed as
Ectoparasitic InfestationsFeeding BehaviorInsecticidesAnimalsBedbugsGene Transfer, HorizontalGenomeHost-Parasite InteractionsHumansInsecticide ResistanceSequence Analysis, DNAInsecticides
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