Evidence map›Paper›PMID 26836631›Full record

ArticleNature communications2016

Genome assembly and geospatial phylogenomics of the bed bug Cimex lectularius.

Jeffrey A Rosenfeld, Darryl Reeves, Mercer R Brugler, Apurva Narechania, Sabrina Simon, Russell Durrett, Jonathan Foox, Kevin Shianna, Michael C Schatz, Jorge Gandara and 17 more

Abstract read
In one paragraph

Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. Article
  2. DNA forensics at forty: the way forward.International journal of legal medicine · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Tracking Adaptive Pathways of Invasive Insects: Novel Insight from Genomics.International journal of molecular sciences · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Resilin is needed for wing posture in Drosophila suzukii.Archives of insect biochemistry and physiology · 2022
    Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Jeffrey A RosenfeldSackler Institute for Comparative Genomics, American Museum of Natural History, New York, New York 10024, USA.
Darryl ReevesDepartment of Physiology and Biophysics, Weill Cornell Medical College, New York, New York 10065, USA.
Mercer R BruglerSackler Institute for Comparative Genomics, American Museum of Natural History, New York, New York 10024, USA.
Apurva NarechaniaSackler Institute for Comparative Genomics, American Museum of Natural History, New York, New York 10024, USA.
Sabrina SimonSackler Institute for Comparative Genomics, American Museum of Natural History, New York, New York 10024, USA.
Russell DurrettDepartment of Physiology and Biophysics, Weill Cornell Medical College, New York, New York 10065, USA.
Jonathan FooxSackler Institute for Comparative Genomics, American Museum of Natural History, New York, New York 10024, USA.
Kevin ShiannaIllumina Inc. 5200 Illumina Way, San Diego, California 92122, USA.
Michael C SchatzSimons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
Jorge GandaraDepartment of Physiology and Biophysics, Weill Cornell Medical College, New York, New York 10065, USA.
Ebrahim AfshinnekooDepartment of Physiology and Biophysics, Weill Cornell Medical College, New York, New York 10065, USA.
Ernest T LamBioNanoGenomics Inc. 9640 Towne Centre Drive Ste. 100, San Diego, California 92121, USA.
Alex R HastieBioNanoGenomics Inc. 9640 Towne Centre Drive Ste. 100, San Diego, California 92121, USA.
Saki ChanBioNanoGenomics Inc. 9640 Towne Centre Drive Ste. 100, San Diego, California 92121, USA.
Han CaoBioNanoGenomics Inc. 9640 Towne Centre Drive Ste. 100, San Diego, California 92121, USA.
Michael SaghbiniBioNanoGenomics Inc. 9640 Towne Centre Drive Ste. 100, San Diego, California 92121, USA.
Alex KentsisMolecular Pharmacology and Chemistry Program, Department of Pediatrics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
Paul J PlanetSackler Institute for Comparative Genomics, American Museum of Natural History, New York, New York 10024, USA.
Vladyslav KholodovychHigh Performance and Research Computing Group, Rutgers Biomedical and Health Sciences, Newark, New Jersey 07103, USA.
Michael TesslerSackler Institute for Comparative Genomics, American Museum of Natural History, New York, New York 10024, USA.
Richard BakerSackler Institute for Comparative Genomics, American Museum of Natural History, New York, New York 10024, USA.
Rob DeSalleSackler Institute for Comparative Genomics, American Museum of Natural History, New York, New York 10024, USA.
Louis N SorkinDivision of Invertebrate Zoology, American Museum of Natural History, New York, New York 10024, USA.
Sergios-Orestis KolokotronisSackler Institute for Comparative Genomics, American Museum of Natural History, New York, New York 10024, USA.ORCID http://orcid.org/0000-0003-3309-8465
Mark E SiddallSackler Institute for Comparative Genomics, American Museum of Natural History, New York, New York 10024, USA.
George AmatoSackler Institute for Comparative Genomics, American Museum of Natural History, New York, New York 10024, USA.
Christopher E MasonDepartment of Physiology and Biophysics, Weill Cornell Medical College, New York, New York 10065, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Epigenome Interactions in Complex Neurogenetic DisordersR01NS076465 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI MASON, CHRISTOPHER EDWARD, ROSS, MARGARET ELIZABETH · 2011 to 2015
$5.8M
Tri-Institutional Training Program in Computational Biology & MedicineT32GM083937 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHRISTINI, DAVID J. · 2009 to 2018
$3.1M
A singular opportunity to determine the evolutionary genetics of retroviral invasR01GM092706 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI ROCA, ALFRED LUIS · 2011 to 2013
$849k
Rapid Identification and Quantification of Organisms from Heterogeneous DNAF31GM111053 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI REEVES, DARRYL ANDREW · 2014 to 2016
$108k
NCI NIH HHS P30 CA008748NIGMS NIH HHS 1T32GM083937NIGMS NIH HHS F31 GM111053NIGMS NIH HHS F31GM111053NIGMS NIH HHS R01 GM092706NIGMS NIH HHS R01GM092706NIGMS NIH HHS T32 GM083937NINDS NIH HHS R01 NS076465NINDS NIH HHS R01NS076465
6 · The paper itself

Abstract

The common bed bug (Cimex lectularius) has been a persistent pest of humans for thousands of years, yet the genetic basis of the bed bug's basic biology and adaptation to dense human environments is largely unknown. Here we report the assembly, annotation and phylogenetic mapping of the 697.9-Mb Cimex lectularius genome, with an N50 of 971 kb, using both long and short read technologies. A RNA-seq time course across all five developmental stages and male and female adults generated 36,985 coding and noncoding gene models. The most pronounced change in gene expression during the life cycle occurs after feeding on human blood and included genes from the Wolbachia endosymbiont, which shows a simultaneous and coordinated host/commensal response to haematophagous activity. These data provide a rich genetic resource for mapping activity and density of C. lectularius across human hosts and cities, which can help track, manage and control bed bug infestations.

Indexed as

Gene Expression Regulation, DevelopmentalAnimalsBedbugsBloodChromosome MappingEatingFemaleGene Expression ProfilingHumansLife Cycle StagesMaleModels, MolecularPhylogenySequence Analysis, RNA

Identifiers

PMID26836631
PMCPMC4740774

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.