ArticleJournal of psychiatry & neuroscience : JPN2016
Aberrant network connectivity during error processing in patients with schizophrenia.
Article in Journal of psychiatry & neuroscience : JPN, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Frontal lobe functioning during a simple response conflict task in first-episode psychosis and its relationship to treatment response.Brain imaging and behavior · 2019Trial
- Nicotine-induced activation of caudate and anterior cingulate cortex in response to errors in schizophrenia.Psychopharmacology · 2018Trial
- Brain network efficiency during social interaction is associated with real-world social network size.Behavioral and brain functions : BBF · 2025Article
- EEG Microstates During Multisensory Stimulation: Assessing the Severity of Disorders of Consciousness and Distinguishing the Minimally Conscious State.Brain sciences · 2025Article
- Article
- EEG microstate co-specificity in schizophrenia and obsessive-compulsive disorder.European archives of psychiatry and clinical neuroscience · 2024Article
- Activation of Internal Correctness Monitoring Circuitry in Youths With Psychosis Spectrum Symptoms.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Multimodal brain deficits shared in early-onset and adult-onset schizophrenia predict positive symptoms regardless of illness stage.Human brain mapping · 2022Article
- Abnormal functional connectivity in the right dorsal anterior insula associated with cognitive dysfunction in patients with type 2 diabetes mellitus.Brain and behavior · 2022Article
- Hypo-activity of the dorsolateral prefrontal cortex relates to increased reaction time variability in patients with schizophrenia.NeuroImage. Clinical · 2019Article
- Joint sparse canonical correlation analysis for detecting differential imaging genetics modules.Bioinformatics (Oxford, England) · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeuroimaging methods have pointed to deficits in the interaction of large-scale brain networks in patients with schizophrenia. Abnormal connectivity of the right anterior insula (AI), a central hub of the salience network, is frequently reported and may underlie patients' deficits in adaptive salience processing and cognitive control. While most previous studies used resting state approaches, we examined right AI interactions in a task-based fMRI study.
methodsPatients with schizophrenia and healthy controls performed an adaptive version of the Eriksen Flanker task that was specifically designed to ensure a comparable number of errors between groups.
resultsWe included 27 patients with schizophrenia and 27 healthy controls in our study. The between-groups comparison replicated the classic finding of reduced activation in the midcingulate cortex (MCC) in patients with schizophrenia during the commission of errors while controlling for confounding factors, such as task performance and error frequency, which have been neglected in many previous studies. Subsequent psychophysiological interaction analysis revealed aberrant functional connectivity (FC) between the right AI and regions in the inferior frontal gyrus and temporoparietal junction. Additionally, FC between the MCC and the dorsolateral prefrontal cortex was reduced. LIMITATIONS: As we examined a sample of medicated patients, effects of antipsychotic medication may have influenced our results.
conclusionOverall, it appears that schizophrenia is associated with impairment of networks associated with detection of errors, refocusing of attention, superordinate guiding of cognitive control and their respective coordination.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.