ArticleMolecular plant pathology2017
Induction of systemic disease resistance in Nicotiana benthamiana by the cyclodipeptides cyclo (l-Pro-l-Pro) and cyclo (d-Pro-d-Pro).
Article in Molecular plant pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Untargeted metabolomics identifies a bacterial cyclic dipeptide that induces resistance to a rust fungus of beans.Scientific reports · 2025Article
- Peptides from plants and microorganisms: a defense strategy for biotic and abiotic stresses.Frontiers in plant science · 2025Review
- Lactic acid induced defense responses in tobacco against Phytophthora nicotianae.Scientific reports · 2024Article
- Article
- Plant Stomata: An Unrealized Possibility in Plant Defense against Invading Pathogens and Stress Tolerance.Plants (Basel, Switzerland) · 2023Review
- Diproline-induced resistance to parasitic nematodes in the same and subsequent rice generations: Roles of iron, nitric oxide and ethylene.Frontiers in plant science · 2023Article
- Immunity functions of Arabidopsis pathogenesis-related 1 are coupled but not confined to its C-terminus processing and trafficking.Molecular plant pathology · 2022Article
- Article
- Bioprospecting of Rhizosphere-Resident Fungi: Their Role and Importance in Sustainable Agriculture.Journal of fungi (Basel, Switzerland) · 2021Review
- Abscisic Acid-Induced Stomatal Closure: An Important Component of Plant Defense Against Abiotic and Biotic Stress.Frontiers in plant science · 2021Review
- The Use of PTI-Marker Genes to Identify Novel Compounds that Establish Induced Resistance in Rice.International journal of molecular sciences · 2020Article
- Diterpenoid compounds from Wedelia trilobata induce resistance to Tomato spotted wilt virus via the JA signal pathway in tobacco plants.Scientific reports · 2019Article
- Stomatal Closure and SA-, JA/ET-Signaling Pathways Are Essential forFrontiers in microbiology · 2018Article
- Seed defense biopriming with bacterial cyclodipeptides triggers immunity in cucumber and pepper.Scientific reports · 2017Article
- Cyclodipeptides: An Overview of Their Biosynthesis and Biological Activity.Molecules (Basel, Switzerland) · 2017Review
- Silicon and Nitrate Differentially Modulate the Symbiotic Performances of Healthy and Virus-Infected Bradyrhizobium-nodulated Cowpea (Vigna unguiculata), Yardlong Bean (V. unguiculata subsp. sesquipedalis) and Mung Bean (V. radiata).Plants (Basel, Switzerland) · 2017Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cyclodipeptides, formed from two amino acids by cyclodehydration, are produced naturally by many organisms, and are known to possess a large number of biological activities. In this study, we found that cyclo (l-Pro-l-Pro) and cyclo (d-Pro-d-Pro) (where Pro is proline) could induce defence responses and systemic resistance in Nicotiana benthamiana. Treatment with the two cyclodipeptides led to a reduction in disease severity by Phytophthora nicotianae and Tobacco mosaic virus (TMV) infections compared with controls. Both cyclopeptides triggered stomatal closure, induced reactive oxygen species production and stimulated cytosolic calcium ion and nitric oxide production in guard cells. In addition, the application of cyclodipeptides significantly up-regulated the expression of the plant defence gene PR-1a and the PR-1a protein, and increased cellular salicylic acid (SA) levels. These results suggest that the SA-dependent defence pathway is involved in cyclodipeptide-mediated pathogen resistance in N. benthamiana. We report the systemic resistance induced by cyclodipeptides, which sheds light on the potential of cyclodipeptides for the control of plant diseases.
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