ArticleJournal of cognitive neuroscience2016
Dissociable Effects of Dopamine on the Initial Capture and the Reactive Inhibition of Impulsive Actions in Parkinson's Disease.
Article in Journal of cognitive neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03665493 (Dopamine Effect on Inhibitory Control), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dopamine Effect on Inhibitory Control
Who cites it
21 citing papers in PubMed.
- Slowed Movement Stopping in Parkinson's Disease and Focal Dystonia is Improved by Standard Treatment.Scientific reports · 2019Trial
- Exploring the spatial interference effects elicited by social and non-social targets: A conditional accuracy function approach.British journal of psychology (London, England : 1953) · 2025Article
- Leveraging time for better impulse control: Longer intervals help ADHD children inhibit impulsive responses.PloS one · 2025Article
- The Role of a Dopamine-Dependent Limbic-Motor Network in Sensory Motor Processing in Parkinson Disease.Journal of cognitive neuroscience · 2023Article
- Huntington disease exacerbates action impulses.Frontiers in psychology · 2023Article
- Towards Conceptual Clarification of Proactive Inhibitory Control: A Review.Brain sciences · 2022Review
- Essential tremor impairs the ability to suppress involuntary action impulses.Experimental brain research · 2022Article
- The arrow of time: Advancing insights into action control from the arrow version of the Eriksen flanker task.Attention, perception & psychophysics · 2021Article
- Modulation of Methamphetamine-Related Attention Bias by Intermittent Theta-Burst Stimulation on Left Dorsolateral Prefrontal Cortex.Frontiers in cell and developmental biology · 2021Article
- Control of response interference: caudate nucleus contributes to selective inhibition.Scientific reports · 2020Article
- Continuous force measurements reveal no inhibitory control deficits in Parkinson's disease.Experimental brain research · 2020Article
- Fast and slow errors: Logistic regression to identify patterns in accuracy-response time relationships.Behavior research methods · 2019Article
- Dopamine effects on frontal cortical blood flow and motor inhibition in Parkinson's disease.Cortex; a journal devoted to the study of the nervous system and behavior · 2019Article
- Levodopa improves response inhibition and enhances striatal activation in early-stage Parkinson's disease.Neurobiology of aging · 2018Article
- ELF: A new measure of response capture.Psychonomic bulletin & review · 2018Review
- A model-based quantification of action control deficits in Parkinson's disease.Neuropsychologia · 2018Article
- Testing the validity of conflict drift-diffusion models for use in estimating cognitive processes: A parameter-recovery study.Psychonomic bulletin & review · 2018Article
- Exposing an "Intangible" Cognitive Skill Among Collegiate Football Players: II. Enhanced Response Impulse Control.Frontiers in psychology · 2018Article
- Focused stimulation of dorsal subthalamic nucleus improves reactive inhibitory control of action impulses.Neuropsychologia · 2017Article
- Response inhibition in Parkinson's disease: a meta-analysis of dopaminergic medication and disease duration effects.NPJ Parkinson's disease · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Dopamine plays a key role in a range of action control processes. Here, we investigate how dopamine depletion caused by Parkinson disease (PD) and how dopamine restoring medication modulate the expression and suppression of unintended action impulses. Fifty-five PD patients and 56 healthy controls (HCs) performed an action control task (Simon task). PD patients completed the task twice, once withdrawn from dopamine medications and once while taking their medications. PD patients experienced similar susceptibility to making fast errors in conflict trials as HCs, but PD patients were less proficient compared with HCs at suppressing incorrect responses. Administration of dopaminergic medications had no effect on impulsive error rates but significantly improved the proficiency of inhibitory control in PD patients. We found no evidence that dopamine precursors and agonists affected action control in PD differently. Additionally, there was no clear evidence that individual differences in baseline action control (off dopamine medications) differentially responded to dopamine medications (i.e., no evidence for an inverted U-shaped performance curve). Together, these results indicate that dopamine depletion and restoration therapies directly modulate the reactive inhibitory control processes engaged to suppress interference from the spontaneously activated response impulses but exert no effect on an individual's susceptibility to act on impulses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.