Evidence map›Paper›PMID 26836448›Full record

ReviewAngewandte Chemie (International ed. in English)2016

Synthetic Strategies toward Natural Products Containing Contiguous Stereogenic Quaternary Carbon Atoms.

Martin Büschleb, Stéphane Dorich, Stephen Hanessian, Daniel Tao, Kyle B Schenthal, Larry E Overman

Abstract readReview
In one paragraph

Review in Angewandte Chemie (International ed. in English), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed.

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  12. Parametrization of κACS catalysis · 2025
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  19. Primary activation ofChemical science · 2024
    Article
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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Martin BüschlebDepartment of Chemistry, Université de Montréal, Station Centre-Ville, C. P. 6128, Montréal, Qc, H3C 3J7, Canada.
Stéphane DorichDepartment of Chemistry, Université de Montréal, Station Centre-Ville, C. P. 6128, Montréal, Qc, H3C 3J7, Canada.
Stephen HanessianDepartment of Chemistry, Université de Montréal, Station Centre-Ville, C. P. 6128, Montréal, Qc, H3C 3J7, Canada. Stephen.hanessian@umontreal.ca.
Daniel TaoDepartment of Chemistry, University of California, 1102 Natural Sciences II, Irvine, CA, 92697-2025, USA.
Kyle B SchenthalDepartment of Chemistry, University of California, 1102 Natural Sciences II, Irvine, CA, 92697-2025, USA.
Larry E OvermanDepartment of Chemistry, University of California, 1102 Natural Sciences II, Irvine, CA, 92697-2025, USA.

Funding

GENERAL METHODS FOR SYNTHESIS OF BIOACTIVE MATERIALSR01GM030859 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI OVERMAN, LARRY E. · 1985 to 2011
$4.0M
New Methods for the Synthesis of Neurological Agents and Other Heterocyclic MolecR01GM098601 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI OVERMAN, LARRY E. · 2011 to 2014
$1.6M
NIGMS NIH HHS R01 GM030859NIGMS NIH HHS R01 GM098601
6 · The paper itself

Abstract

Strategies for the total synthesis of complex natural products that contain two or more contiguous stereogenic quaternary carbon atoms in their intricate structures are reviewed with 12 representative examples. Emphasis has been put on methods to create quaternary carbon stereocenters, including syntheses of the same natural product by different groups, thereby showcasing the diversity of thought and individual creativity. A compendium of selected natural products containing two or more contiguous stereogenic quaternary carbon atoms and key reactions in their total or partial syntheses is provided in the Supporting Information.

Indexed as

Biological ProductsCarbonBiological ProductsCarbonbiomimetic synthesisnatural productsquaternary carbon atomssynthetic methods

Identifiers

PMID26836448
PMCPMC4865016

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.