Trial reportTranslational psychiatry2016
Neuroplasticity in response to cognitive behavior therapy for social anxiety disorder.
Trial report in Translational psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01312571 (Functional Magnetic Resonance Imaging), which is not on this map. Cited by 47 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Functional Magnetic Resonance Imaging (fMRI) and Treatment of Social Phobia Over the Internet: Cognitive Behavioural Therapy (CBT) Versus Computerized Attention Training and the Possible Effect of Genetic Variation. (SOFIE-8)
Who cites it
47 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- The effect of cognitive behavioral therapy on depressive symptoms in parents of children with special needs: a systematic review and meta-analysis of randomized controlled trials.Systematic reviews · 2025Pooled it
- Pooled it
- Activation Likelihood Estimation Meta-Analysis of the Effects of Cognitive Behavioral Therapy on Brain Activation in the Treatment of Depression and Anxiety Disorders.Depression and anxiety · 2025Pooled it
- Gray matter abnormalities in patients with major depressive disorder and social anxiety disorder: a voxel-based meta-analysis.Brain imaging and behavior · 2023Pooled it
- Pathological fear, anxiety and negative affect exhibit distinct neurostructural signatures: evidence from psychiatric neuroimaging meta-analysis.Translational psychiatry · 2022Pooled it
- Trial
- Cognitive Behavioral Therapy for Anxiety in Parkinson's Disease Induces Functional Brain Changes.Journal of Parkinson's disease · 2023Trial
- Improvement in indices of cellular protection after psychological treatment for social anxiety disorder.Translational psychiatry · 2019Trial
- Plasma short-chain fatty acid concentrations in social anxiety disorder and changes after cognitive behavioral therapy.Translational psychiatry · 2026Article
- Early Individualized Psychological Intervention Using Virtual Reality-assisted Decision System Reduces Decisional Conflict in Patients with Pulmonary Nodules: A Randomized Controlled Trial.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026Article
- Prefrontal Cortex Dysfunction as a Precipitating Factor for Schizophrenia and Depression.Journal of neurochemistry · 2026Review
- Improvement of anxious but not depressive symptoms is associated with functional outcomes of psychocardiological rehabilitation.Scientific reports · 2025Article
- Neuroscientific Framework of Cognitive-Behavioral Interventions for Mental Health Across Diverse Cultural Populations: A Systematic Review of Effectiveness, Delivery Methods, and Engagement.European journal of investigation in health, psychology and education · 2025Review
- Limbic gray matter increases in response to cognitive-behavioral therapy in major depressive disorder.Translational psychiatry · 2025Article
- Autonomic Readiness for Social Threats in Patients with Social Anxiety Disorder.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025Article
- Genetic and Environmental Influences on Anxiety Disorders: A Systematic Review of Their Onset and Development.Cureus · 2025Review
- Insights from a methylome-wide association study of antidepressant exposure.Nature communications · 2025Article
- Interventions for Neural Plasticity in Stroke Recovery.Archives of internal medicine research · 2025Article
- The Limbic System in Co-Occurring Substance Use and Anxiety Disorders: A Narrative Review Using the RDoC Framework.Brain sciences · 2024Review
- Annual Research Review: Neuroimmune network model of depression: a developmental perspective.Journal of child psychology and psychiatry, and allied disciplines · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with anxiety disorders exhibit excessive neural reactivity in the amygdala, which can be normalized by effective treatment like cognitive behavior therapy (CBT). Mechanisms underlying the brain's adaptation to anxiolytic treatments are likely related both to structural plasticity and functional response alterations, but multimodal neuroimaging studies addressing structure-function interactions are currently missing. Here, we examined treatment-related changes in brain structure (gray matter (GM) volume) and function (blood-oxygen level dependent, BOLD response to self-referential criticism) in 26 participants with social anxiety disorder randomly assigned either to CBT or an attention bias modification control treatment. Also, 26 matched healthy controls were included. Significant time × treatment interactions were found in the amygdala with decreases both in GM volume (family-wise error (FWE) corrected P(FWE) = 0.02) and BOLD responsivity (P(FWE) = 0.01) after successful CBT. Before treatment, amygdala GM volume correlated positively with anticipatory speech anxiety (P(FWE)=0.04), and CBT-induced reduction of amygdala GM volume (pre-post) correlated positively with reduced anticipatory anxiety after treatment (P(FWE) ⩽ 0.05). In addition, we observed greater amygdala neural responsivity to self-referential criticism in socially anxious participants, as compared with controls (P(FWE) = 0.029), before but not after CBT. Further analysis indicated that diminished amygdala GM volume mediated the relationship between decreased neural responsivity and reduced social anxiety after treatment (P=0.007). Thus, our results suggest that improvement-related structural plasticity impacts neural responsiveness within the amygdala, which could be essential for achieving anxiety reduction with CBT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.