Evidence map›Paper›PMID 26836236›Full record

ArticleAIDS patient care and STDs2016

I Knew I Would Be Safer. Experiences of Kenyan HIV Serodiscordant Couples Soon After Pre-Exposure Prophylaxis (PrEP) Initiation.

Kenneth Ngure, Renee Heffron, Kathyrn Curran, Sophie Vusha, Mariah Ngutu, Nelly Mugo, Connie Celum, Jared M Baeten

Abstract read
In one paragraph

Article in AIDS patient care and STDs, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 53 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Kenneth Ngure1 School of Public Health, Jomo Kenyatta University of Agriculture and Technology , Kenya .
Renee Heffron2 Department of Global Health, University of Washington , Seattle, Washington.
Kathyrn Curran2 Department of Global Health, University of Washington , Seattle, Washington.
Sophie Vusha5 Center for Clinical Research, Kenya Medical Research Institute , Kenya .
Mariah Ngutu5 Center for Clinical Research, Kenya Medical Research Institute , Kenya .
Nelly Mugo2 Department of Global Health, University of Washington , Seattle, Washington.
Connie Celum2 Department of Global Health, University of Washington , Seattle, Washington.
Jared M Baeten2 Department of Global Health, University of Washington , Seattle, Washington.
University of Washington · USKenya Medical Research Institute · KEJomo Kenyatta University of Agriculture and Technology · KE

Funding

Optimizing Antiretroviral-Based HIV Prevention for HIV Serodiscordant CouplesR01MH095507 · NIMH · UNIVERSITY OF WASHINGTON · PI BAETEN, JARED · 2011 to 2020
$6.1M
Antiretroviral periconception HIV prevention for HIV discordant couplesR00HD076679 · NICHD · UNIVERSITY OF WASHINGTON · PI HEFFRON, RENEE A. · 2015 to 2017
$742k
NICHD NIH HHS R00 HD076679NIMH NIH HHS R01 MH095507
6 · The paper itself

Abstract

Pre-exposure prophylaxis (PrEP) for HIV-uninfected persons is highly efficacious for HIV prevention. Understanding how people at risk for HIV will use PrEP is important to inform PrEP scale-up and implementation. We used qualitative methods to gather insights into couples' early experiences with PrEP use within the Partners Demonstration Project, an open-label implementation study evaluating integrated delivery of PrEP and antiretroviral therapy (ART). PrEP is offered to HIV uninfected partners until the HIV-infected partner initiates and sustains ART use (i.e., PrEP as a "bridge" to ART initiation and viral suppression). From August 2013 to March 2014 we conducted 20 in-depth dyadic interviews (n = 40) with heterosexual HIV serodiscordant couples participating at the Thika, Kenya study site, exploring how couples make decisions about using PrEP for HIV prevention. We developed and applied deductive and inductive codes to identify key themes related to experiences of PrEP initiation and use of time-limited PrEP. Couples reported that PrEP offered them an additional strategy to reduce the risk of HIV transmission, meet their fertility desires, and cope with HIV serodiscordance. Remaining HIV negative at follow-up visits reinforced couples' decisions and motivated continued adherence to PrEP. In addition, confidence in their provider's advice and client-friendly services were critical to their decisions to initiate and continue use of PrEP. Strategies for wide-scale PrEP delivery for HIV serodiscordant couples in low resource settings may include building capacity of health providers to counsel on PrEP adoption while addressing couples' concerns and barriers to adoption and continued use.

Indexed as

HIV SeronegativityPre-Exposure ProphylaxisAdultAnti-HIV AgentsBlack PeopleFamily CharacteristicsFemaleFertilityHeterosexualityHIV InfectionsHIV SeropositivityHumansInterviews as TopicKenyaMaleMotivationAnti-HIV Agents

Identifiers

PMID26836236
PMCPMC4753630
OpenAlexW2254734542

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.