Evidence map›Paper›PMID 26836227›Full record

ReviewWiley interdisciplinary reviews. Cognitive science

Tackling the 'dyslexia paradox': reading brain and behavior for early markers of developmental dyslexia.

Ola Ozernov-Palchik, Nadine Gaab

Abstract readReview
In one paragraph

Review in Wiley interdisciplinary reviews. Cognitive science. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 1 pooled it
21.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 1 synthesis or guideline pooled it, 190 citations in OpenAlex.

  1. Pooled it
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  16. White matter and literacy: A dynamic system in flux.Developmental cognitive neuroscience · 2024
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ola Ozernov-PalchikLaboratories of Cognitive Neuroscience, Division of Developmental Medicine, Department of Medicine, Boston Children's Hospital, Boston, MA, USA.
Nadine GaabLaboratories of Cognitive Neuroscience, Division of Developmental Medicine, Department of Medicine, Boston Children's Hospital, Boston, MA, USA.
Boston Children's Hospital · US

Funding

Longitudinal Study of childhood fMRI markers prior to reading onsetR01HD065762 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI GAAB, NADINE, GRANT, PATRICIA ELLEN · 2011 to 2021
$6.3M
Using Cognitive Neuroscience to Predict Dyslexia among Kindergarden ChildrenR01HD067312 · NICHD · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GAAB, NADINE, GABRIELI, JOHN · 2011 to 2015
$3.1M
NICHD NIH HHS 1R01HD065762NICHD NIH HHS 1R01HD067312NICHD NIH HHS R01 HD065762NICHD NIH HHS R01 HD067312
6 · The paper itself

Abstract

Developmental dyslexia is an unexplained inability to acquire accurate or fluent reading that affects approximately 5-17% of children. Dyslexia is associated with structural and functional alterations in various brain regions that support reading. Neuroimaging studies in infants and pre-reading children suggest that these alterations predate reading instruction and reading failure, supporting the hypothesis that variant function in dyslexia susceptibility genes lead to atypical neural migration and/or axonal growth during early, most likely in utero, brain development. Yet, dyslexia is typically not diagnosed until a child has failed to learn to read as expected (usually in second grade or later). There is emerging evidence that neuroimaging measures, when combined with key behavioral measures, can enhance the accuracy of identification of dyslexia risk in pre-reading children but its sensitivity, specificity, and cost-efficiency is still unclear. Early identification of dyslexia risk carries important implications for dyslexia remediation and the amelioration of the psychosocial consequences commonly associated with reading failure.

Indexed as

AnimalsBiomarkersBrainBrain MappingChildChild, PreschoolDiffusion Tensor ImagingDyslexiaElectroencephalographyEvoked PotentialsFemaleHumansInfantInfant, NewbornMagnetic Resonance ImagingReadingBiomarkers

Identifiers

PMID26836227
PMCPMC4761294
OpenAlexW2285898800

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.