ArticleJournal of biomedical optics2016
Minimally invasive surgical method to detect sound processing in the cochlear apex by optical coherence tomography.
Article in Journal of biomedical optics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Distinctive mechanical response characteristics of the guinea pig apical cochlear organ of Corti and basilar membrane.The Journal of general physiology · 2026Article
- On the phase consistency of apical organ of Corti vibrations.Hearing research · 2024Article
- Tuning and Timing of Organ of Corti Vibrations at the Apex of the Intact Chinchilla Cochlea.Journal of the Association for Research in Otolaryngology : JARO · 2024Article
- Linear mixed-effect modeling of organ of Corti vibratory tuning curves.Hearing research · 2023Article
- The reticular lamina and basilar membrane vibrations in the transverse direction in the basal turn of the living gerbil cochlea.Scientific reports · 2022Article
- Outer hair cell driven reticular lamina mechanical distortion in living cochleae.Hearing research · 2022Review
- Two-tone distortion in reticular lamina vibration of the living cochlea.Communications biology · 2020Article
- Revealing the morphology and function of the cochlea and middle ear with optical coherence tomography.Quantitative imaging in medicine and surgery · 2019Review
- A mechanoelectrical mechanism for detection of sound envelopes in the hearing organ.Nature communications · 2018Article
- Timing of the reticular lamina and basilar membrane vibration in living gerbil cochleae.eLife · 2018Article
- Mechanical tuning and amplification within the apex of the guinea pig cochlea.The Journal of physiology · 2017Article
- Experimental Visualization of Labyrinthine Structure with Optical Coherence Tomography.Iranian journal of otorhinolaryngology · 2017Article
- Minimal basilar membrane motion in low-frequency hearing.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Auditory Function and Natural History of 645 Auditory Neuropathy Patients Over a 27-Year Span in China.Ear and hearingArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Sound processing in the inner ear involves separation of the constituent frequencies along the length of the cochlea. Frequencies relevant to human speech (100 to 500 Hz) are processed in the apex region. Among mammals, the guinea pig cochlear apex processes similar frequencies and is thus relevant for the study of speech processing in the cochlea. However, the requirement for extensive surgery has challenged the optical accessibility of this area to investigate cochlear processing of signals without significant intrusion. A simple method is developed to provide optical access to the guinea pig cochlear apex in two directions with minimal surgery. Furthermore, all prior vibration measurements in the guinea pig apex involved opening an observation hole in the otic capsule, which has been questioned on the basis of the resulting changes to cochlear hydrodynamics. Here, this limitation is overcome by measuring the vibrations through the unopened otic capsule using phase-sensitive Fourier domain optical coherence tomography. The optically and surgically advanced method described here lays the foundation to perform minimally invasive investigation of speech-related signal processing in the cochlea.
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Registered trials
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