Evidence map›Paper›PMID 2683611›Full record

ReviewAdvances in immunology1989

Biology of natural killer cells.

G Trinchieri

Registry-linked trialAbstract readReview
In one paragraph

Review in Advances in immunology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01810120 (Phase I/II Study of Allogeneic Hematopoietic Stem Cell Transplantation From an HLA-partially Matched Family Donor After TCR Alfa Beta Negative Selection in Pediatric Patients Affected by Hematological Disorders), which is not on this map. Cited by 757 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
757citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01810120 phase1 / phase2completednot on this mapstarted 2012, after this paper: background citation

Phase I/II Study of Allogeneic Hematopoietic Stem Cell Transplantation From an HLA-partially Matched Family Donor After TCR Alfa Beta Negative Selection in Pediatric Patients Affected by Hematological Disorders

TypeinterventionalSponsorMariella EnocRan2012 to 2016Enrolled30ConditionsAcute Lymphoblastic Leukemia, Leukemia Acute Myeloid - AML, Non-Hodgkin Lymphoma, Myelodysplastic SyndromesArmsTCR alfa beta T cell depletion
3 · Its place in the literature

Who cites it

757 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. The Effects of Forest Therapy on Immune Function.International journal of environmental research and public health · 2021
    Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Overview of the host immune response toJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025
    Review
  13. Adaptive NKG2CEuropean journal of immunology · 2025
    Article
  14. Natural killer cells: the immune frontline against circulating tumor cells.Journal of experimental & clinical cancer research : CR · 2025
    Review
  15. Review
  16. Article
  17. The clinical landscape of CAR NK cells.Experimental hematology & oncology · 2025
    Review
  18. Review
  19. Review
  20. Review

697 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

G TrinchieriWistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104.

Funding

Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Maureen E. Murphy · 1985 to 2026
$75.9M
CELL-MEDIATED CYTOTOXICITY IN HUMANSR01CA020833 · NCI · WISTAR INSTITUTE · PI KAUFMAN, RUSSEL E. · 1985 to 2003
$1.9M
DIFFERENTIATION AND FUNCTION OF MONOCYTESR01CA032898 · NCI · WISTAR INSTITUTE · PI SANTOLI, DANIELA · 1985 to 1994
–
CELL-MEDIATED CYTOTOXICITY IN HUMANSR37CA020833 · NCI · WISTAR INSTITUTE · PI TRINCHIERI, GIORGIO · 1990 to 1998
–
NCI NIH HHS CA 10815NCI NIH HHS CA 20833NCI NIH HHS CA 32898
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Killer Cells, NaturalAnimalsAntigens, DifferentiationCell DifferentiationCell MovementCytotoxicity, ImmunologicCytotoxinsFemaleHematopoiesisHormonesHumansImmunologic Deficiency SyndromesInfectionsLeukemiaLymphoid TissueLymphokinesAntigens, DifferentiationCytotoxinsHormonesLymphokinesReceptors, Immunologic

Identifiers

PMID2683611
PMCPMC7131425

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.