ArticleeNeuro
Pleiotropic Control by Testosterone of a Learned Vocal Behavior and Its Underlying Neuroplasticity(1,2,3).
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 58 citations in OpenAlex.
- Neurochemical Characterization of Dopaminoceptive Cells in Song Control Nuclei of Canaries and Their Activation During Song Production: A Multiplex Fluorescent In Situ Hybridization Study.The Journal of comparative neurology · 2024Article
- Song system neuroanatomy, and immediate early gene expression in a finch species with extensive male and female song.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Article
- Androgen signaling in LMAN regulates song stereotypy in male canaries.Hormones and behavior · 2024Article
- Androgen receptor deficiency is associated with reduced aromatase expression in the ventromedial hypothalamus of male cichlids.Annals of the New York Academy of Sciences · 2024Article
- Steroid-dependent plasticity in the song control system: Perineuronal nets and HVC neurogenesis.Frontiers in neuroendocrinology · 2023Review
- Breaking Through the Bottleneck: Krogh's Principle in Behavioral Neuroendocrinology and the Potential of Gene Editing.Integrative and comparative biology · 2023Review
- Sex differences in song syntax and syllable diversity in testosterone-induced songs of adult male and female canaries.Biology of sex differences · 2023Article
- Genetic dissection of steroid-hormone modulated social behavior: Novel paralogous genes are a boon for discovery.Hormones and behavior · 2023Review
- Reciprocal processes of sensory perception and social bonding: an integrated social-sensory framework of social behavior.Genes, brain, and behavior · 2022Review
- Birdsong and the Neural Regulation of Positive Emotion.Frontiers in psychology · 2022Review
- Perinatal activation of ERJournal of neurophysiology · 2021Article
- Unilateral vocal nerve resection alters neurogenesis in the avian song system in a region-specific manner.PloS one · 2021Article
- Perineuronal nets in HVC and plasticity in male canary song.PloS one · 2021Article
- Sex differences and similarities in the neural circuit regulating song and other reproductive behaviors in songbirds.Neuroscience and biobehavioral reviews · 2020Review
- Testosterone stimulates perineuronal nets development around parvalbumin cells in the adult canary brain in parallel with song crystallization.Hormones and behavior · 2020Article
- Seasonal changes of perineuronal nets and song learning in adult canaries (Serinus canaria).Behavioural brain research · 2020Article
- New concepts in the study of the sexual differentiation and activation of reproductive behavior, a personal view.Frontiers in neuroendocrinology · 2019Review
- Rapid testosterone-induced growth of the medial preoptic nucleus in male canaries.Physiology & behavior · 2019Article
- Hormonal regulation of social ascent and temporal patterns of behavior in an African cichlid.Hormones and behavior · 2019Article
- Differential control of appetitive and consummatory sexual behavior by neuroestrogens in male quail.Hormones and behavior · 2018Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
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Abstract
Steroid hormones coordinate multiple aspects of behavior and physiology. The same hormone often regulates different aspects of a single behavior and its underlying neuroplasticity. This pleiotropic regulation of behavior and physiology is not well understood. Here, we investigated the orchestration by testosterone (T) of birdsong and its neural substrate, the song control system. Male canaries were castrated and received stereotaxic implants filled with T in select brain areas. Implanting T solely in the medial preoptic nucleus (POM) increased the motivation to sing, but did not enhance aspects of song quality such as acoustic structure and stereotypy. In birds implanted with T solely in HVC (proper name), a key sensorimotor region of the song control system, little or no song was observed, similar to castrates that received no T implants of any sort. However, implanting T in HVC and POM simultaneously rescued all measures of song quality. Song amplitude, though, was still lower than what was observed in birds receiving peripheral T treatment. T in POM enhanced HVC volume bilaterally, likely due to activity-dependent changes resulting from an enhanced song rate. T directly in HVC, without increasing song rate, enhanced HVC volume on the ipsilateral side only. T in HVC enhanced the incorporation and recruitment of new neurons into this nucleus, while singing activity can independently influence the incorporation of new neurons into HVC. These results have broad implications for how steroid hormones integrate across different brain regions to coordinate complex social behaviors.
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