SynthesiseNeuro
Gray Matter Features of Reading Disability: A Combined Meta-Analytic and Direct Analysis Approach(1,2,3,4).
Synthesis in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Are there shared neural correlates between dyslexia and ADHD? A meta-analysis of voxel-based morphometry studies.Journal of neurodevelopmental disorders · 2019Pooled it
- Neuroanatomical differences in early bilingual and monolingual children.bioRxiv : the preprint server for biology · 2026Article
- A discovery and replication study of dyslexia does not reveal reproducible gray matter volume differences.bioRxiv : the preprint server for biology · 2026Article
- Dyslexia Data Consortium: A Comprehensive Platform for Neuroimaging Data Sharing, Analysis, and Advanced Research in Dyslexia.Neuroinformatics · 2025Article
- Twin differences in lateral ventricle size accompany twin differences in phonological decoding.Brain structure & function · 2025Article
- An examination of cortical thickness relationships within the reading network of adults.Brain structure & function · 2024Article
- Distinct impact modes of polygenic disposition to dyslexia in the adult brain.Science advances · 2024Article
- From teeth to brain: dental caries causally affects the cortical thickness of the banks of the superior temporal sulcus.BMC oral health · 2024Article
- Cortical Structure in Pre-Readers at Cognitive Risk for Dyslexia: Baseline Differences and Response to Intervention.Neurobiology of language (Cambridge, Mass.) · 2024Article
- Auditory Cortex Asymmetry Associations with Individual Differences in Language and Cognition.Brain sciences · 2023Article
- Characterization of Cortical and Subcortical Structural Brain Asymmetry in Adults with and without Dyslexia.Brain sciences · 2023Article
- Dyslexia Data Consortium Repository: A Data Sharing and Delivery Platform for Research.Brain informatics : 16th International Conference, BI 2023, Hoboken, NJ, USA, August 1-3, 2023, Proceedings. International Conference on Brain Informatics (16th : 2023 : Hoboken, N.J.) · 2023Article
- Deep learning classification of reading disability with regional brain volume features.NeuroImage · 2023Article
- Genetic determinants of individual variation in the superior temporal sulcus of chimpanzees (Pan troglodytes).Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Shared grey matter correlates of reading and attention.Brain and language · 2023Article
- An fMRI study of finger movements in children with and without dyslexia.Frontiers in neuroscience · 2023Article
- Neural dissociation of visual attention span and phonological deficits in developmental dyslexia: A hub-based white matter network analysis.Human brain mapping · 2022Article
- Gray matter volume differences between early bilinguals and monolinguals: A study of children and adults.Human brain mapping · 2022Article
- Seeking Overlapping Neuroanatomical Alterations between Dyslexia and Attention-Deficit/Hyperactivity Disorder: A Meta-Analytic Replication Study.Brain sciences · 2022Article
- Genome-wide analyses of individual differences in quantitatively assessed reading- and language-related skills in up to 34,000 people.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Meta-analysis of voxel-based morphometry dyslexia studies and direct analysis of 293 reading disability and control cases from six different research sites were performed to characterize defining gray matter features of reading disability. These analyses demonstrated consistently lower gray matter volume in left posterior superior temporal sulcus/middle temporal gyrus regions and left orbitofrontal gyrus/pars orbitalis regions. Gray matter volume within both of these regions significantly predicted individual variation in reading comprehension after correcting for multiple comparisons. These regional gray matter differences were observed across published studies and in the multisite dataset after controlling for potential age and gender effects, and despite increased anatomical variance in the reading disability group, but were not significant after controlling for total gray matter volume. Thus, the orbitofrontal and posterior superior temporal sulcus gray matter findings are relatively reliable effects that appear to be dependent on cases with low total gray matter volume. The results are considered in the context of genetics studies linking orbitofrontal and superior temporal sulcus regions to alleles that confer risk for reading disability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.