Evidence map›Paper›PMID 26835507›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2015

Using florbetapir positron emission tomography to explore cerebrospinal fluid cut points and gray zones in small sample sizes.

Philip S J Weston, Ross W Paterson, Marc Modat, Ninon Burgos, Manuel J Cardoso, Nadia Magdalinou, Manja Lehmann, John C Dickson, Anna Barnes, Jamshed B Bomanji and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Development of a sensitive trial-ready poly(GP) CSF biomarker assay forJournal of neurology, neurosurgery, and psychiatry · 2022
    Article
  3. Article
  4. Cerebrospinal Fluid Biomarkers in Cerebral Amyloid Angiopathy.Journal of Alzheimer's disease : JAD · 2020
    Article
  5. Article
  6. Article
  7. The functional neuroanatomy of musical memory in Alzheimer's disease.Cortex; a journal devoted to the study of the nervous system and behavior · 2019
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 5 institutions in 3 countries.

Philip S J WestonDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Ross W PatersonDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Marc ModatDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK; Transitional Imaging Group, Centre for Medical Image Computing, University College London, London, UK.
Ninon BurgosTransitional Imaging Group, Centre for Medical Image Computing, University College London, London, UK.
Manuel J CardosoDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK; Transitional Imaging Group, Centre for Medical Image Computing, University College London, London, UK.
Nadia MagdalinouReta Lila Weston Institute of Neurological Studies, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
Manja LehmannDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
John C DicksonInstitute of Nuclear Medicine, University College London Hospitals, London, UK.
Anna BarnesInstitute of Nuclear Medicine, University College London Hospitals, London, UK.
Jamshed B BomanjiInstitute of Nuclear Medicine, University College London Hospitals, London, UK.
Irfan KayaniInstitute of Nuclear Medicine, University College London Hospitals, London, UK.
David M CashDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Sebastien OurselinTransitional Imaging Group, Centre for Medical Image Computing, University College London, London, UK.
Jamie ToombsMRC Centre for Neuromuscular Disease, Department of Molecular Neuroscience, UCL Institute of Neurology, University College London, London, UK.
Michael P LunnMRC Centre for Neuromuscular Disease, Department of Molecular Neuroscience, UCL Institute of Neurology, University College London, London, UK.
Catherine J MummeryDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Jason D WarrenDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Martin N RossorDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Nick C FoxDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Henrik ZetterbergMRC Centre for Neuromuscular Disease, Department of Molecular Neuroscience, UCL Institute of Neurology, University College London, London, UK; Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Jonathan M SchottDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
University College London · GBUK Dementia Research Institute · GBInstitute of Molecular Medicine · INRoyal London Hospital · GBUniversity College Hospital · GB

Funding

Medical Research Council MR/J01107X/1Medical Research Council MR/K006584/1Medical Research Council MR/M003108/1Wellcome Trust
6 · The paper itself

Abstract

introductionWe aimed to assess the feasibility of determining Alzheimer's disease cerebrospinal fluid (CSF) cut points in small samples through comparison with amyloid positron emission tomography (PET).

methodsTwenty-three individuals (19 patients, four controls) had CSF measures of amyloid beta (Aβ)

resultsSeventeen of 23 were amyloid-positive on visual reads, and 14 of 23 at an SUVR of ≥1.1. There was concordance (positive/negative on both measures) in 20 of 23, of whom 19 of 20 were correctly classified at an Aβ DISCUSSION: Comparing amyloid PET and CSF biomarkers provides a means of assessing CSF cut points in vivo, and can be applied to small sample sizes. CSF tau/Aβ

Indexed as

Amyloid PETAβCerebrospinal fluidCut pointsDiagnosisPhosphorylated tauTau

Identifiers

PMID26835507
PMCPMC4691234
OpenAlexW2105010736

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.