Evidence map›Paper›PMID 26835486›Full record

ArticleNeurophotonics2016

Transcranial low-level laser therapy (810 nm) temporarily inhibits peripheral nociception: photoneuromodulation of glutamate receptors, prostatic acid phophatase, and adenosine triphosphate.

Marcelo Victor Pires de Sousa, Cleber Ferraresi, Masayoshi Kawakubo, Beatriz Kaippert, Elisabeth Mateus Yoshimura, Michael R Hamblin

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurophotonics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Treatments in oral lichen planus: a review.Frontiers in oral health · 2026
    Review
  6. Effects of Low-Level Laser Therapy and Purified Natural Latex (International journal of molecular sciences · 2023
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Marcelo Victor Pires de SousaMassachusetts General Hospital, Wellman Center for Photomedicine, BAR414, 40 Blossom Street, Boston, Massachusetts 02114, United States; University of São Paulo, Institute of Physics, Laboratory of Radiation Dosimetry and Medical Physics, Rua do Matão, Travessa R, 187, Cidade Universitária, São Paulo, Brazil; Bright Photomedicine Ltd., CIETEC Building, 2242 Lineu Prestes, São Paulo 05508-000, Brazil.
Cleber FerraresiMassachusetts General Hospital, Wellman Center for Photomedicine, BAR414, 40 Blossom Street, Boston, Massachusetts 02114, United States; Federal University of São Carlos, Department of Physical Therapy, Laboratory of Electro-Thermo-Phototherapy, Street Washington Luis, km 235. Monjolinho, São Carlos, São Paulo 13565-905, Brazil; Federal University of São Carlos, Post-Graduation Program in Biotechnology, Street Washington Luis, km 235. Monjolinho, São Carlos, São Paulo 13560-000, Brazil; University of São Paulo, Optics Group, Physics Institute of São Carlos, Street Miguel Petroni, 146-Jardim Bandeirantes, São Carlos, São Paulo 13560-970, Brazil.
Masayoshi KawakuboMassachusetts General Hospital , Wellman Center for Photomedicine, BAR414, 40 Blossom Street, Boston, Massachusetts 02114, United States.
Beatriz KaippertMassachusetts General Hospital, Wellman Center for Photomedicine, BAR414, 40 Blossom Street, Boston, Massachusetts 02114, United States; Federal University of Rio de Janeiro, Carlos Chagas Filho, 373-Cidade Universitária, Rio de Janeiro, RJ 21941-170, Brazil.
Elisabeth Mateus YoshimuraUniversity of São Paulo , Institute of Physics, Laboratory of Radiation Dosimetry and Medical Physics, Rua do Matão, Travessa R, 187, Cidade Universitária, São Paulo, Brazil.
Michael R HamblinMassachusetts General Hospital, Wellman Center for Photomedicine, BAR414, 40 Blossom Street, Boston, Massachusetts 02114, United States; Harvard Medical School, Department of Dermatology, 50 Staniford Street #807, Boston, Massachusetts 02114, United States; Harvard-MIT, Division of Health Sciences and Technology, 77 Massachusetts Avenue, E25-518, Cambridge, Massachusetts 02139, United States.
Massachusetts General Hospital · USUniversidade de São Paulo · BRUniversidade Federal do Rio de Janeiro · BR

Funding

Photodynamic Therapy of Localized InfectionsR01AI050875 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2003 to 2017
$4.8M
NIAID NIH HHS R01 AI050875
6 · The paper itself

Abstract

Photobiomodulation or low-level light therapy has been shown to attenuate both acute and chronic pain, but the mechanism of action is not well understood. In most cases, the light is applied to the painful area, but in the present study we applied light to the head. We found that transcranial laser therapy (TLT) applied to mouse head with specific parameters (810 nm laser, [Formula: see text], 7.2 or [Formula: see text]) decreased the reaction to pain in the foot evoked either by pressure (von Frey filaments), cold, or inflammation (formalin injection) or in the tail (evoked by heat). The pain threshold increasing is maximum around 2 h after TLT, remains up to 6 h, and is finished 24 h after TLT. The mechanisms were investigated by quantification of adenosine triphosphate (ATP), immunofluorescence, and hematoxylin and eosin (H&E) staining of brain tissues. TLT increased ATP and prostatic acid phosphatase (an endogenous analgesic) and reduced the amount of glutamate receptor (mediating a neurotransmitter responsible for conducting nociceptive information). There was no change in the concentration of tubulin, a constituent of the cytoskeleton, and the H&E staining revealed no tissue damage. This is the first study to show inhibition of peripheral pain due to photobiomodulation of the central nervous system.

Indexed as

adenosine triphosphatecold plate testformalin injectionmetabotropic glutamate receptornociceptionpain thresholdphotobiomodulationprostatic acid phosphatasetail flick testtranscranial low-level laser therapyVon Frey filaments

Identifiers

PMID26835486
PMCPMC4725212
OpenAlexW2253787186

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.