ArticleFrontiers in public health2016
Optimal Versus Realized Trajectories of Physiological Dysregulation in Aging and Their Relation to Sex-Specific Mortality Risk.
Article in Frontiers in public health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Validation of a Deficit-Accumulation Frailty Index in the ASPirin in Reducing Events in the Elderly Study and Its Predictive Capacity for Disability-Free Survival.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Trial
- Change in the Rate of Biological Aging in Response to Caloric Restriction: CALERIE Biobank Analysis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Trial
- Article
- Pilot application of an inflammation and physiological dysregulation index based on noninvasive salivary biomarkers.BMC research notes · 2025Article
- Age-related physiological dysregulation progresses slowly in semi-free-ranging chimpanzees.Evolution, medicine, and public health · 2024Article
- Interactions between genes involved in physiological dysregulation and axon guidance: role in Alzheimer's disease.Frontiers in genetics · 2023Article
- Global, regional and national burden of endocrine, metabolic, blood and immune disorders 1990-2019: a systematic analysis of the Global Burden of Disease study 2019.Frontiers in endocrinology · 2023Article
- An objective metric of individual health and aging for population surveys.Population health metrics · 2022Article
- Evidence from two cohorts for the frailty syndrome as an emergent state of parallel dysregulation in multiple physiological systems.Biogerontology · 2021Article
- Robust Physiological Metrics From Sparsely Sampled Networks.Frontiers in physiology · 2021Review
- Multi-system physiological dysregulation and ageing in a subsistence population.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Association of Blood Chemistry Quantifications of Biological Aging With Disability and Mortality in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Greater tree cover near residence is associated with reduced allostatic load in residents of central North Carolina.Environmental research · 2020Article
- Genetics of physiological dysregulation: findings from the long life family study using joint models.Aging · 2020Article
- Composite Measure of Physiological Dysregulation as a Predictor of Mortality: The Long Life Family Study.Frontiers in public health · 2020Article
- Functional aging in health and heart failure: the COmPLETE Study.BMC cardiovascular disorders · 2019Article
- Article
- "Physiological Dysregulation" as a Promising Measure of Robustness and Resilience in Studies of Aging and a New Indicator of Preclinical Disease.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Differences between Men and Women in Mortality and the Health Dimensions of the Morbidity Process.Clinical chemistry · 2019Review
- Men Sustain Higher Dysregulation Levels Than Women Without Becoming Frail.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
While longitudinal changes in biomarker levels and their impact on health have been characterized for individual markers, little is known about how overall marker profiles may change during aging and affect mortality risk. We implemented the recently developed measure of physiological dysregulation based on the statistical distance of biomarker profiles in the framework of the stochastic process model of aging, using data on blood pressure, heart rate, cholesterol, glucose, hematocrit, body mass index, and mortality in the Framingham original cohort. This allowed us to evaluate how physiological dysregulation is related to different aging-related characteristics such as decline in stress resistance and adaptive capacity (which typically are not observed in the data and thus can be analyzed only indirectly), and, ultimately, to estimate how such dynamic relationships increase mortality risk with age. We found that physiological dysregulation increases with age; that increased dysregulation is associated with increased mortality, and increasingly so with age; and that, in most but not all cases, there is a decreasing ability to return quickly to baseline physiological state with age. We also revealed substantial sex differences in these processes, with women becoming dysregulated more quickly but with men showing a much greater sensitivity to dysregulation in terms of mortality risk.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.