Evidence map›Paper›PMID 26835326›Full record

ReviewTranslational pediatrics2014

Mesenchymal stem cells: potential application in intervertebral disc regeneration.

Aiqun Wei, Bojiang Shen, Lisa Williams, Ashish Diwan

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Translational pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 59 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Aiqun Wei1 Department of Orthopaedic Research, Orthopaedic Research Institute, St George Hospital University of New South Wales, Sydney, Australia ; 2 Department of Cell & Molecular Therapies, Royal Prince Alfred Hospital, Sydney, Australia.
Bojiang Shen1 Department of Orthopaedic Research, Orthopaedic Research Institute, St George Hospital University of New South Wales, Sydney, Australia ; 2 Department of Cell & Molecular Therapies, Royal Prince Alfred Hospital, Sydney, Australia.
Lisa Williams1 Department of Orthopaedic Research, Orthopaedic Research Institute, St George Hospital University of New South Wales, Sydney, Australia ; 2 Department of Cell & Molecular Therapies, Royal Prince Alfred Hospital, Sydney, Australia.
Ashish Diwan1 Department of Orthopaedic Research, Orthopaedic Research Institute, St George Hospital University of New South Wales, Sydney, Australia ; 2 Department of Cell & Molecular Therapies, Royal Prince Alfred Hospital, Sydney, Australia.
Royal Prince Alfred Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic low back pain is one of the leading public health problems in developed countries. Degeneration of the intervertebral disc (IVD) is a major pathological process implicated in low back pain, which is characterized by cellular apoptosis and senescence with reduced synthesis of extracellular matrix (ECM). Currently, there is no clinical therapy targeting the reversal of disc degeneration. Recent advances in cellular and molecular biology have provided an exciting approach to disc regeneration that focuses on the delivery of viable cells to the degenerative disc. Adult mesenchymal stem cells (MSCs) are multipotent stem cells with self-renewal capacities and are able to differentiate into diverse specialized cell types, including chondrocyte lineages. The potential of stem cell therapy in disc degeneration is to repopulate the disc with viable cells capable of producing the ECM and restoring damaged tissue. The present literature review summarizes recent advances in basic research and clinical trials of MSCs to provide an outline of the key roles of MSCs therapies in disc repair. The review also discusses the controversies, challenges and therapeutic concepts for the future.

Indexed as

back paindegenerationintervertebral disc (IVD)Mesenchymal stem cell (MSC)regeneration

Identifiers

PMID26835326
PMCPMC4729108
OpenAlexW2174687840

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.