Evidence map›Paper›PMID 26835268›Full record

ArticleTranslational pediatrics2012

MRI-DWI improves the early diagnosis of brain abscess induced by Candida albicans in preterm infants.

Jian Mao, Juan Li, Dan Chen, Jing Zhang, Ya-Nan Du, Ying-Jie Wang, Xin Li, Rui Wang, Li-Ying Chen, Xiao-Ming Wang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational pediatrics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Single and Repeated Episodes ofFrontiers in microbiology · 2021
    Article
  4. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Jian Mao1 Department of Pediatrics, Shengjing Hospital, China Medical University, Shenyang 110004, China ; 2 Department of Radiology, Shengjing Hospital, China Medical University, Shenyang 110004, China.
Juan Li1 Department of Pediatrics, Shengjing Hospital, China Medical University, Shenyang 110004, China ; 2 Department of Radiology, Shengjing Hospital, China Medical University, Shenyang 110004, China.
Dan Chen1 Department of Pediatrics, Shengjing Hospital, China Medical University, Shenyang 110004, China ; 2 Department of Radiology, Shengjing Hospital, China Medical University, Shenyang 110004, China.
Jing Zhang1 Department of Pediatrics, Shengjing Hospital, China Medical University, Shenyang 110004, China ; 2 Department of Radiology, Shengjing Hospital, China Medical University, Shenyang 110004, China.
Ya-Nan Du1 Department of Pediatrics, Shengjing Hospital, China Medical University, Shenyang 110004, China ; 2 Department of Radiology, Shengjing Hospital, China Medical University, Shenyang 110004, China.
Ying-Jie Wang1 Department of Pediatrics, Shengjing Hospital, China Medical University, Shenyang 110004, China ; 2 Department of Radiology, Shengjing Hospital, China Medical University, Shenyang 110004, China.
Xin Li1 Department of Pediatrics, Shengjing Hospital, China Medical University, Shenyang 110004, China ; 2 Department of Radiology, Shengjing Hospital, China Medical University, Shenyang 110004, China.
Rui Wang1 Department of Pediatrics, Shengjing Hospital, China Medical University, Shenyang 110004, China ; 2 Department of Radiology, Shengjing Hospital, China Medical University, Shenyang 110004, China.
Li-Ying Chen1 Department of Pediatrics, Shengjing Hospital, China Medical University, Shenyang 110004, China ; 2 Department of Radiology, Shengjing Hospital, China Medical University, Shenyang 110004, China.
Xiao-Ming Wang1 Department of Pediatrics, Shengjing Hospital, China Medical University, Shenyang 110004, China ; 2 Department of Radiology, Shengjing Hospital, China Medical University, Shenyang 110004, China.
China Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the diagnostic value of magnetic resonance imaging (MRI) in brain abscess induced by invasive fungal infection (IFI) of the central nervous system.

methodsThe clinical data of eight preterm infants with IFI of the central nervous system were retrospectively analyzed. All these eight children received three sequential brain MRI modes T1WI, T2WI and DWI during hospitalization and after discharge.

resultsAll these eight preterm infants were infected with Candida albicans, seven of which were manifested by brain abscess and four were accompanied by meningitis. MRI of seven infants with brain abscess indicated extensive invasion including involvement of subcortical white matter, deep periventricular white matter and semiovale center white matter. MRI examination was conducted within 11 d following infection on four cases and showed diffuse or multiple miliary nodules, hyper-intense signal on DWI, while insignificant signal changes on T1WI and T2WI. DWI signal nearly disappeared three weeks later. T1WI/T2WI signal changed most significantly 2-4 weeks following infection, with nodules ring-shaped, hyper-intense signal around T1WI and hypo-intense signal in the center. Signal on T2WI was just on the opposite. Severe cases presented fusion of different degrees. Significant enhanced effect was observed on T1WI. Four weeks later, the lesion gradually became fewer and smaller on T1WI, transferred into dot or line-like hyper-intense signal and presented obviously hypo-intense signal on T2WI. Dynamic MRI of two cases showed delayed myelination and corpus callosum thinning.

conclusionMRI-DWI and dynamic MRI changes can improve the early diagnosis of brain abscess induced by Candida albicans in preterm infants.

Indexed as

Brain abscessCandida albicansmagnetic resonance imagingpreterm infants

Identifiers

PMID26835268
PMCPMC4728877
OpenAlexW1944068864

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.