ArticleSpringerPlus2016
Serum α-klotho concentrations during preimplantation can predict aging or quality of human oocytes and clinical pregnancy rates.
Article in SpringerPlus, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Unveiling the Emerging Role of Klotho: A Comprehensive Narrative Review of an Anti-aging Factor in Human Fertility.Current protein & peptide science · 2025Review
- Advanced maternal age impairs spatial learning capacity in young adult mouse offspring.American journal of translational research · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
backgroundTo discover simple biomarkers to evaluate the aging or quality of human oocytes and clinical pregnancy rates is needed. However, the association among serum α-klotho concentrations during preimplantation, the aging or quality of human oocytes and clinical pregnancy rates has not been investigated.
findingsThe serum α-klotho concentrations during preimplantation decreased due to aging (p < 0.001), whereas the maturation rates of human oocytes (p < 0.001) and the fertilization rates (p < 0.001) improved in association with increased serum α-klotho concentrations. Furthermore, multiple logistic regression analysis showed that the clinical pregnancy rates were influenced by serum α-klotho concentrations during preimplantation (p < 0.001), the patient's age (p = 0.003), maturation rates of human oocytes (p < 0.001), fertilization rates (p < 0.001) and the serum 25 (OH) D levels (p < 0.001) regardless of race (p = 0.29) and BMI (p = 0.96).
conclusionThe serum α-klotho concentrations during preimplantation would be a simple biomarker in order to predict the aging or quality of human oocytes and clinical pregnancy rates.
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Registered trials
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