ArticleArrhythmia & electrophysiology review2015
Biology of the Sinus Node and its Disease.
Article in Arrhythmia & electrophysiology review, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Dual Nature of Sinoatrial Node Remodelling in Athletes: A Systematic Review of Electrophysiological Adaptations and the Pathological Tipping Point.International journal of molecular sciences · 2025Pooled it
- Genome-wide association study of heart rate and its variability in Hispanic/Latino cohorts.Heart rhythm · 2017Trial
- Epidemiology of pacemaker implantation in the community: findings from the Framingham Heart Study.International journal of cardiology. Heart & vasculature · 2026Article
- Formulation Design of Amiodarone Hydrochloride Tablets Optimized for a Continuous Manufacturing Process.Pharmaceutics · 2026Article
- Aberrant TMPRSS6-Protease Regulation of Disease Mutant HCN4-KCNE1 Channel Complex Depends on the KCNE1-G38S Polymorphism.Archiv der Pharmazie · 2026Article
- Spatial transcriptomic profiling of developing mouse hearts reveals a spatially patterned signaling environment.Communications biology · 2026Article
- Transient chronotropic incompetence owing to sinus node modification after superior vena cava isolation - A rare complication.HeartRhythm case reports · 2026Article
- Inferior Sino-Atrial Node Exit Sites Are Associated With Electrical Remodeling.JACC. Clinical electrophysiology · 2026Article
- Intrinsic Versus Extrinsic Sinus and Atrioventricular Nodes Dysfunction in Athletes: Insights From Transesophageal Electrophysiological Testing With Autonomic Blockade.Reviews in cardiovascular medicine · 2025Article
- Practical compendium of antiarrhythmic drugs: a clinical consensus statement of the European Heart Rhythm Association of the European Society of Cardiology.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Review
- Rotating Frame Relaxation Time Mapping for the Visualization of the Sinoatrial Node Without Contrast Agent.NMR in biomedicine · 2025Article
- Focal endocardial pulsed-field ablation for the treatment of inappropriate sinus tachycardia: A case report.HeartRhythm case reports · 2025Article
- Mid-term effects on sinus node function following additional empirical superior vena cava isolation in atrial fibrillation patients with sick sinus syndrome.Journal of arrhythmia · 2025Article
- Differential effects of anesthetics and sex on supraventricular electrophysiology and atrial fibrillation substrate in rats.Lab animal · 2025Article
- Does Long-Term Sport Practice Facilitate the Development of Idiopathic Bradycardia Requiring Early Pacemaker Implantation During the Course of Life?Journal of cardiovascular development and disease · 2025Article
- Right coronary ostial atresia as a cause of arrhythmia and cardiogenic shock in a young woman: a case report.BJR case reports · 2025Article
- Cardiac automaticity is modulated by IKACh in sinoatrial node during pregnancy.Cardiovascular research · 2024Article
- Decoding the molecular, cellular, and functional heterogeneity of zebrafish intracardiac nervous system.Nature communications · 2024Article
- Cardiac conduction diseases: understanding the molecular mechanisms to uncover targets for future treatments.Expert opinion on therapeutic targets · 2024Review
- Infection with COVID-19 Complicated by Sinus Arrest.Case reports in infectious diseases · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The sinoatrial node (SAN) is the normal pacemaker of the heart and SAN dysfunction (SND) is common, but until recently the pathophysiology was incompletely understood. It was usually attributed to idiopathic age-related fibrosis and cell atrophy or ischaemia. It is now evident that changes in the electrophysiology of the SAN, known as electrical remodelling, is an important process that has been demonstrated in SND associated with heart failure, ageing, diabetes, atrial fibrillation and endurance exercise. Furthermore, familial SND has been identified and mutations have been characterised in key pacemaker genes of the SAN. This review summarises the current evidence regarding SAN function and the pathophysiology of SND.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.