Evidence map›Paper›PMID 26834994›Full record

ArticleF1000Research2015

Machine learning models identify molecules active against the Ebola virus

Sean Ekins, Joel S Freundlich, Alex M Clark, Manu Anantpadma, Robert A Davey, Peter Madrid

Open access · goldAbstract read
In one paragraph

Article in F1000Research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.

  1. Pooled it
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  8. 1-Sulfonyl-3-amino-1ACS omega · 2023
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  12. A Review of the Machine Learning Algorithms for Covid-19 Case Analysis.IEEE transactions on artificial intelligence · 2023
    Article
  13. The Commoditization of AI for Molecule Design.Artificial intelligence in the life sciences · 2022
    Article
  14. Multiple approaches to repurposing drugs for neuroblastoma.Bioorganic & medicinal chemistry · 2022
    Article
  15. Review
  16. Review
  17. Article
  18. Machine Learning Models Identify Inhibitors of SARS-CoV-2.Journal of chemical information and modeling · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Sean EkinsCollaborations in Chemistry, Fuquay-Varina, NC, 27526, USA.
Joel S FreundlichDepartments of Pharmacology & Physiology and Medicine, Center for Emerging and Reemerging Pathogens, UMDNJ, New Jersey Medical School, Newark, NJ, 07103, USA.
Alex M ClarkMolecular Materials Informatics, Inc., Montreal, 94025, Canada.
Manu AnantpadmaTexas Biomedical Research Institute, San Antonio, TX, 78227, USA.
Robert A DaveyTexas Biomedical Research Institute, San Antonio, TX, 78227, USA.
Peter MadridSRI International, Menlo Park, CA, 94025, USA.
Texas Biomedical Research Institute · USCollaborative Drug Discovery (United States) · USMolecular Oncology (United States) · USRutgers, The State University of New Jersey · USSRI International · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The search for small molecule inhibitors of Ebola virus (EBOV) has led to several high throughput screens over the past 3 years. These have identified a range of FDA-approved active pharmaceutical ingredients (APIs) with anti-EBOV activity

Indexed as

Computational modelsDrug repurposingEbola VirusMachine learningPharmacophorePyronaridineQuinacrineTilorone

Identifiers

PMID26834994
PMCPMC4706063
OpenAlexW4233790983

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.