Evidence map›Paper›PMID 26834985›Full record

ArticleF1000Research2015

iCTNet2: integrating heterogeneous biological interactions to understand complex traits.

Lili Wang, Daniel S Himmelstein, Adam Santaniello, Mousavi Parvin, Sergio E Baranzini

Abstract read
In one paragraph

Article in F1000Research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Selective Estrogen Receptor Modulators Enhance CNS Remyelination Independent of Estrogen Receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
    Article
  5. The multiplex network of human diseases.NPJ systems biology and applications · 2019
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lili WangSchool of Computing, Queen's University, Kingston, Ontario, K7L 3N6, Canada.
Daniel S HimmelsteinGraduate Program in Biological and Medical Informatics, University of California, San Francisco, San Francisco, CA, 94143-0523, USA.
Adam SantanielloDepartment of Neurology, University of California San Francisco, San Francisco, CA, 94158, USA.
Mousavi ParvinSchool of Computing, Queen's University, Kingston, Ontario, K7L 3N6, Canada.
Sergio E BaranziniDepartment of Neurology, University of California San Francisco, San Francisco, CA, 94158, USA; Graduate Program in Biological and Medical Informatics, University of California, San Francisco, San Francisco, CA, 94143-0523, USA.

Funding

BMI Bioinformatics Training GrantsT32GM067547 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HERNANDEZ, RYAN D. · 2003 to 2022
$6.6M
Integrative Program in Complex Biological System (ipCBS)T32EB009383 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARSHALL, WALLACE, WEINER, ORION D · 2009 to 2022
$3.2M
Post GWAS approach to identify cell-specific genetic pathways underlying MS riskR01NS088155 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BARANZINI, SERGIO E · 2014 to 2018
$2.2M
NIBIB NIH HHS T32 EB009383NIGMS NIH HHS T32 GM067547NINDS NIH HHS R01 NS088155
6 · The paper itself

Abstract

iCTNet (integrated Complex Traits Networks) version 2 is a Cytoscape app and database that allows researchers to build heterogeneous networks by integrating a variety of biological interactions, thus offering a systems-level view of human complex traits. iCTNet2 is built from a variety of large-scale biological datasets, collected from public repositories to facilitate the building, visualization and analysis of heterogeneous biological networks in a comprehensive fashion via the Cytoscape platform. iCTNet2 is freely available at the Cytoscape app store.

Indexed as

big data integrationdisease ontologydrug re-purposingheterogeneous network

Identifiers

PMID26834985
PMCPMC4706053

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.