Evidence map›Paper›PMID 26834947›Full record

ArticleWorld journal of radiology2016

Texture analysis on parametric maps derived from dynamic contrast-enhanced magnetic resonance imaging in head and neck cancer.

Jacobus Fa Jansen, Yonggang Lu, Gaorav Gupta, Nancy Y Lee, Hilda E Stambuk, Yousef Mazaheri, Joseph O Deasy, Amita Shukla-Dave

Open access · hybridAbstract read
In one paragraph

Article in World journal of radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
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  7. Review
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  10. MRI heterogeneity analysis for prediction of recurrence and disease free survival in anal cancer.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2019
    Article
  11. The utility of MRI histogram and texture analysis for the prediction of histological diagnosis in head and neck malignancies.Cancer imaging : the official publication of the International Cancer Imaging Society · 2019
    Article
  12. Article
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  15. Observational
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  18. "Radio-oncomics" : The potential of radiomics in radiation oncology.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2017
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jacobus Fa JansenJacobus FA Jansen, Department of Radiology, Maastricht University Medical Center, 6211 LK Maastricht, the Netherlands.
Yonggang LuJacobus FA Jansen, Department of Radiology, Maastricht University Medical Center, 6211 LK Maastricht, the Netherlands.
Gaorav GuptaJacobus FA Jansen, Department of Radiology, Maastricht University Medical Center, 6211 LK Maastricht, the Netherlands.
Nancy Y LeeJacobus FA Jansen, Department of Radiology, Maastricht University Medical Center, 6211 LK Maastricht, the Netherlands.
Hilda E StambukJacobus FA Jansen, Department of Radiology, Maastricht University Medical Center, 6211 LK Maastricht, the Netherlands.
Yousef MazaheriJacobus FA Jansen, Department of Radiology, Maastricht University Medical Center, 6211 LK Maastricht, the Netherlands.
Joseph O DeasyJacobus FA Jansen, Department of Radiology, Maastricht University Medical Center, 6211 LK Maastricht, the Netherlands.
Amita Shukla-DaveJacobus FA Jansen, Department of Radiology, Maastricht University Medical Center, 6211 LK Maastricht, the Netherlands.
Maastricht University Medical Centre · NL

Funding

MR Dynamic Imaging and Spectroscopy in Head & Neck CancersR01CA115895 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI DAVE, AMITA · 2006 to 2010
$1.6M
NCI NIH HHS R01 CA115895
6 · The paper itself

Abstract

aimTo investigate the merits of texture analysis on parametric maps derived from pharmacokinetic modeling with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) as imaging biomarkers for the prediction of treatment response in patients with head and neck squamous cell carcinoma (HNSCC).

methodsIn this retrospective study, 19 HNSCC patients underwent pre- and intra-treatment DCE-MRI scans at a 1.5T MRI scanner. All patients had chemo-radiation treatment. Pharmacokinetic modeling was performed on the acquired DCE-MRI images, generating maps of volume transfer rate (K(trans)) and volume fraction of the extravascular extracellular space (ve). Image texture analysis was then employed on maps of K(trans) and ve, generating two texture measures: Energy (E) and homogeneity.

resultsNo significant changes were found for the mean and standard deviation for K(trans) and ve between pre- and intra-treatment (P > 0.09). Texture analysis revealed that the imaging biomarker E of ve was significantly higher in intra-treatment scans, relative to pretreatment scans (P < 0.04).

conclusionChemo-radiation treatment in HNSCC significantly reduces the heterogeneity of tumors.

Indexed as

Dynamic contrast-enhanced magnetic resonance imagingHead and neck squamous cell carcinomasImage texture analysisTumor heterogeneity

Identifiers

PMID26834947
PMCPMC4731352
OpenAlexW2415944286

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.