ArticleFrontiers in plant science2016
Fruit Ripening Regulation of α-Mannosidase Expression by the MADS Box Transcription Factor RIPENING INHIBITOR and Ethylene.
Article in Frontiers in plant science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 61 citations in OpenAlex.
- Fruit-Specific Promoters in Plants: Advances, Regulatory Mechanisms and Applications in Plant Biotechnology.Plants (Basel, Switzerland) · 2026Review
- Ethylene-Mediated Regulation of a Ripening-Specific N-glycan-processing enzyme β-D-N-Acetylhexosaminidase.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Transcriptome analysis reveals regulatory mechanism of postharvest softening in kiwiberry.BMC plant biology · 2024Article
- Involvement of the GH38 Family Exoglycosidase α-Mannosidase in Strawberry Fruit Ripening.International journal of molecular sciences · 2024Article
- Metabolomics to understand metabolic regulation underpinning fruit ripening, development, and quality.Journal of experimental botany · 2024Review
- Identification and application of an exocarp-preferential promoter for genetic engineering of tomato fruit.Horticulture research · 2024Article
- Dissection of mRNA acMolecular horticulture · 2024Article
- Transcriptome Analysis Reveals the Molecular Regularity Mechanism Underlying Stem Bulblet Formation in Oriental Lily 'Siberia'; Functional Characterization of theInternational journal of molecular sciences · 2022Article
- A comparative transcriptomics and eQTL approach identifies SlWD40 as a tomato fruit ripening regulator.Plant physiology · 2022Article
- Genome Editing Technology for Genetic Amelioration of Fruits and Vegetables for Alleviating Post-Harvest Loss.Bioengineering (Basel, Switzerland) · 2022Review
- N-Acetylglucosamine Sensing and Metabolic Engineering for Attenuating Human and Plant Pathogens.Bioengineering (Basel, Switzerland) · 2022Review
- Identification of yield-related genes through genome-wide association: case study of weeping forsythia, an emerging medicinal crop.Genes & genomics · 2022Article
- The metabolic changes that effect fruit quality during tomato fruit ripening.Molecular horticulture · 2022Review
- WRKY genes provide novel insights into their role againstFrontiers in plant science · 2022Article
- Sugar and acid profile of loquat (Frontiers in plant science · 2022Article
- Unraveling the role of tomato Bcl-2-associated athanogene (BAG) proteins during abiotic stress response and fruit ripening.Scientific reports · 2021Article
- Sweet Modifications Modulate Plant Development.Biomolecules · 2021Review
- Suppression of3 Biotech · 2020Article
- LncRNA regulates tomato fruit cracking by coordinating gene expression via a hormone-redox-cell wall network.BMC plant biology · 2020Article
- Construction of a High-Density Genetic Map and Mapping of Firmness in Grapes (International journal of molecular sciences · 2020Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
α-Mannosidase (α-Man), a fruit ripening-specific N-glycan processing enzyme, is involved in ripening-associated fruit softening process. However, the regulation of fruit-ripening specific expression of α-Man is not well understood. We have identified and functionally characterized the promoter of tomato (Solanum lycopersicum) α-Man to provide molecular insights into its transcriptional regulation during fruit ripening. Fruit ripening-specific activation of the α-Man promoter was revealed by analysing promoter driven expression of beta-glucuronidase (GUS) reporter in transgenic tomato. We found that RIPENING INHIBITOR (RIN), a MADS box family transcription factor acts as positive transcriptional regulator of α-Man during fruit ripening. RIN directly bound to the α-Man promoter sequence and promoter activation/α-Man expression was compromised in rin mutant fruit. Deletion analysis revealed that a promoter fragment (567 bp upstream of translational start site) that contained three CArG boxes (binding sites for RIN) was sufficient to drive GUS expression in fruits. In addition, α-Man expression was down-regulated in fruits of Nr mutant which is impaired in ethylene perception and promoter activation/α-Man expression was induced in wild type following treatment with a precursor of ethylene biosynthesis, 1-aminocyclopropane-1-carboxylic acid (ACC). Although, α-Man expression was induced in rin mutant after ACC treatment, the transcript level was less as compared to ACC-treated wild type. Taken together, these results suggest RIN-mediated direct transcriptional regulation of α-Man during fruit ripening and ethylene may acts in RIN-dependent and -independent ways to regulate α-Man expression.
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