ArticleFrontiers in immunology2015
Adipose Mesenchymal Stem Cells Isolated after Manual or Water-jet-Assisted Liposuction Display Similar Properties.
Article in Frontiers in immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Analyzing the Clinical Potential of Stromal Vascular Fraction: A Comprehensive Literature Review.Medicina (Kaunas, Lithuania) · 2024Pooled it
- Stemness and clinical performance of water-jet technology: A translational study in breast reconstruction.JPRAS open · 2025Article
- Molecular Regulation of Thermogenic Mechanisms in Beige Adipocytes.International journal of molecular sciences · 2024Review
- Extracellular vesicles from senescent mesenchymal stromal cells are defective and cannot prevent osteoarthritis.Journal of nanobiotechnology · 2024Article
- Women's contribution to stem cell research for osteoarthritis: an opinion paper.Frontiers in cell and developmental biology · 2023Review
- Editorial: Biology and clinical applications of adipose-derived cells for skeletal regeneration.Frontiers in bioengineering and biotechnology · 2023Article
- Inter-center comparison of good manufacturing practices-compliant stromal vascular fraction and proposal for release acceptance criteria: a review of 364 productions.Stem cell research & therapy · 2021Review
- Extracellular Vesicles Are More Potent Than Adipose Mesenchymal Stromal Cells to Exert an Anti-Fibrotic Effect in an In Vitro Model of Systemic Sclerosis.International journal of molecular sciences · 2021Article
- Accentuating the sources of mesenchymal stem cells as cellular therapy for osteoarthritis knees-a panoramic review.Stem cell investigation · 2021Review
- Autologous fat grafting: Harvesting techniques.Annals of medicine and surgery (2012) · 2018Review
- Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis.Theranostics · 2018Article
- Adipose tissue-derived stromal vascular fraction in regenerative medicine: a brief review on biology and translation.Stem cell research & therapy · 2017Review
- Adipose-derived mesenchymal stem cells from liposuction and resected fat are feasible sources for regenerative medicine.European journal of medical research · 2017Article
- Adipose-Derived Mesenchymal Stem Cells in Autoimmune Disorders: State of the Art and Perspectives for Systemic Sclerosis.Clinical reviews in allergy & immunology · 2017Review
- Effect of Stromal Vascular Fractions on Angiogenesis of Injected Diced Cartilage.The Journal of craniofacial surgeryArticle
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mesenchymal stem or stromal cells (MSC) are under investigation in many clinical trials for their therapeutic potential in a variety of diseases, including autoimmune and inflammatory disorders. One of the main sources of MSCs is the adipose tissue, which is mainly obtained by manual liposuction using a cannula linked to a syringe. However, in the past years, a number of devices for fat liposuction intended for clinical use have been commercialized but few papers have compared these procedures in terms of stromal vascular fraction (SVF) or adipose mesenchymal stromal cells (ASC). The objective of the present study was to compare and qualify for clinical use the ASC obtained from fat isolated with the manual or the Bodyjet(®) water-jet-assisted procedure. Although the initial number of cells obtained after collagenase digestion was higher with the manual procedure, the percentage of dead cells, the number of colony forming unit-fibroblast and the phenotype of cells were identical in the SVF at isolation (day 0) and in the ASC populations at day 14. We also showed that the osteogenic and adipogenic differentiation potentials of ASCs were identical between preparations while a slight but significant higher in vitro immunosuppressive effect was observed with ASCs isolated from fat removed with a cannula. The difference in the immunomodulatory effect between ASC populations was, however, not observed in vivo using the delayed-type hypersensitivity (DTH) model. Our data, therefore, indicate that the procedure for fat liposuction does not impact the characteristics or the therapeutic function of ASCs.
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