ArticleFrontiers in microbiology2015
Genomic Investigation of a Legionellosis Outbreak in a Persistently Colonized Hotel.
Article in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Legionellosis Associated with Recreational Waters: A Systematic Review of Cases and Outbreaks in Swimming Pools, Spa Pools, and Similar Environments.International journal of environmental research and public health · 2018Pooled it
- Comparative genome analysis investigation of nosocomial and community-acquired cases of Legionnaires' disease caused by ST2858 and ST378.Microbiology spectrum · 2025Article
- Characterisation ofMicroorganisms · 2024Article
- High performanceApplied and environmental microbiology · 2024Article
- Rapid adaptations ofMicrobial genomics · 2023Article
- Comparative Genomics ofMicroorganisms · 2023Article
- Genome analysis ofLife science alliance · 2022Article
- A Community Outbreak of Legionnaires' Disease with Two Strains ofInternational journal of environmental research and public health · 2022Article
- Natural outbreaks and bioterrorism: How to deal with the two sides of the same coin?Journal of global health · 2020Review
- A Snapshot of the Prevalence and Molecular Diversity ofPathogens (Basel, Switzerland) · 2020Article
- Multiple Sources of the Outbreak of Legionnaires' Disease in Genesee County, Michigan, in 2014 and 2015.Environmental health perspectives · 2019Article
- Factors associated with Legionnaires' disease recurrence in hotel and holiday rental accommodation sites.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2019Article
- Electrophoretic mobility of Legionella pneumophila serogroups 1 to 14.FEMS microbiology letters · 2018Article
- Genome Sequencing Links Persistent Outbreak of Legionellosis in Sydney (New South Wales, Australia) to an Emerging Clone of Legionella pneumophila Sequence Type 211.Applied and environmental microbiology · 2018Article
- Genomic heterogeneity differentiates clinical and environmental subgroups of Legionella pneumophila sequence type 1.PloS one · 2018Article
- Street Cleaning Trucks as Potential Sources of Legionella pneumophila.Emerging infectious diseases · 2017Article
- Epidemiological information is key when interpreting whole genome sequence data - lessons learned from a largeEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2017Article
- A Supervised Statistical Learning Approach for Accurate Legionella pneumophila Source Attribution during Outbreaks.Applied and environmental microbiology · 2017Article
- Dynamics and impact of homologous recombination on the evolution of Legionella pneumophila.PLoS genetics · 2017Article
- Seeding and Establishment of Legionella pneumophila in Hospitals: Implications for Genomic Investigations of Nosocomial Legionnaires' Disease.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesA long-lasting legionellosis outbreak was reported between November 2011 and July 2012 in a hotel in Calpe (Spain) affecting 44 patients including six deaths. Intensive epidemiological and microbiological investigations were performed in order to detect the reservoirs.
methodsClinical and environmental samples were tested for the presence and genetic characterization of Legionella pneumophila. Six of the isolates were subjected to whole-genome sequencing.
resultsSequencing of 14 clinical and 260 environmental samples revealed sequence type (ST) 23 as the main responsible strain for the infections. This ST was found in the spa pool, from where it spread to other hotel public spaces, explaining the ST23 clinical cases, including guests who had not visited the spa. Uncultured clinical specimens showed profiles compatible with ST23, ST578, and mixed patterns. Profiles compatible with ST578 were obtained by direct sequencing from biofilm samples collected from the domestic water system, which provided evidence for the source of infection for non ST23 patients. Whole genome data from five ST23 strains and the identification of different STs and Legionella species showed that different hotel premises were likely colonized since the hotel opening thus explaining how different patients had been infected by distinct STs.
conclusionsBoth epidemiological and molecular data are essential in the investigation of legionellosis outbreaks. Whole-genome sequencing data revealed significant intra-ST variability and allowed to make further inference on the short-term evolution of a local colonization of L. pneumophila.
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