ArticleFrontiers in aging neuroscience2015
Age-Related Modifications of Diffusion Tensor Imaging Parameters and White Matter Hyperintensities as Inter-Dependent Processes.
Article in Frontiers in aging neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cerebral small vessel disease genomics and its implications across the lifespan.Nature communications · 2020Pooled it
- Free water: A marker of age-related modifications of the cingulum white matter and its association with cognitive decline.PloS one · 2020Trial
- A comparative evaluation of brain MRI modalities, modality-specific measures, brain regions, and cognitive tests for brain age prediction.GeroScience · 2026Article
- Role of disturbed structural connectivity network in patients with white matter lesions and cognitive impairment revealed by diffusion-tensor magnetic resonance imaging.The Journal of international medical research · 2026Article
- Frailty subtypes and white matter alterations in older adults without dementia.Psychiatry and clinical neurosciences · 2025Article
- The impact of occupational nonhypoxic hypobaria on cerebral function and integrity.Scientific reports · 2025Observational
- Longitudinal diffusion tensor imaging correlates with amyloid burden in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Glymphatic system and psychiatric disorders: need for a new paradigm?Frontiers in psychiatry · 2025Review
- Clinical utility of diffusion tensor imaging in sport-related concussion: a systematic review.BJR open · 2025Article
- Viability of AMURA biomarkers from single-shell diffusion MRI in clinical studies.Frontiers in neuroscience · 2023Article
- Normal-Appearing White Matter Deteriorates over the Year After an Ischemic Stroke and Is Associated with Global Cognition.Translational stroke research · 2022Article
- Genetics of common cerebral small vessel disease.Nature reviews. Neurology · 2022Review
- The Function of the Autonomic Nervous System in Asian Patients With Chronic Migraine.Frontiers in neuroscience · 2022Article
- Aging of the Nigrostriatal Tract in the Human Brain: A Diffusion Tensor Imaging Study.Medicina (Kaunas, Lithuania) · 2021Article
- The effect of vascular health factors on white matter microstructure mediates age-related differences in executive function performance.Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
- White Matter Hyperintensity Volume and Location: Associations With WM Microstructure, Brain Iron, and Cerebral Perfusion.Frontiers in aging neuroscience · 2021Article
- Alternative Microstructural Measures to Complement Diffusion Tensor Imaging in Migraine Studies with Standard MRI Acquisition.Brain sciences · 2020Article
- Aortic Stiffness and White Matter Microstructural Integrity Assessed by Diffusion Tensor Imaging: The ARIC-NCS.Journal of the American Heart Association · 2020Article
- Effects of chemotherapy on aging white matter microstructure: A longitudinal diffusion tensor imaging study.Journal of geriatric oncology · 2020Article
- Retinal sublayer defect is independently associated with the severity of hypertensive white matter hyperintensity.Brain and behavior · 2020Article
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Authors and funding
11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Microstructural changes of White Matter (WM) associated with aging have been widely described through Diffusion Tensor Imaging (DTI) parameters. In parallel, White Matter Hyperintensities (WMH) as observed on a T2-weighted MRI are extremely common in older individuals. However, few studies have investigated both phenomena conjointly. The present study investigates aging effects on DTI parameters in absence and in presence of WMH. Diffusion maps were constructed based on 21 directions DTI scans of young adults (n = 19, mean age = 33 SD = 7.4) and two age-matched groups of older adults, one presenting low-level-WMH (n = 20, mean age = 78, SD = 3.2) and one presenting high-level-WMH (n = 20, mean age = 79, SD = 5.4). Older subjects with low-level-WMH presented modifications of DTI parameters in comparison to younger subjects, fitting with the DTI pattern classically described in aging, i.e., Fractional Anisotropy (FA) decrease/Radial Diffusivity (RD) increase. Furthermore, older subjects with high-level-WMH showed higher DTI modifications in Normal Appearing White Matter (NAWM) in comparison to those with low-level-WMH. Finally, in older subjects with high-level-WMH, FA, and RD values of NAWM were associated with to WMH burden. Therefore, our findings suggest that DTI modifications and the presence of WMH would be two inter-dependent processes but occurring within different temporal windows. DTI changes would reflect the early phase of white matter changes and WMH would appear as a consequence of those changes.
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