ReviewFrontiers in neural circuits2015
The Slow Oscillation in Cortical and Thalamic Networks: Mechanisms and Functions.
Review in Frontiers in neural circuits, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04206059 (Closed Loop Acoustic Stimulation During Sedation With Dexmedetomidine), which is not on this map. Cited by 173 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Closed Loop Acoustic Stimulation During Sedation With Dexmedetomidine
Who cites it
173 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- The Effects of Transcranial Electrical Stimulation of the Brain on Sleep: A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- Closed-loop modulation of sleep in children undergoing intracranial recordings.Cell reports. Medicine · 2026Trial
- Infraslow Closed-Loop Brain Training for Anxiety and Depression (ISAD): A pilot randomised, sham-controlled trial in adult females with internalizing disorders.Cognitive, affective & behavioral neuroscience · 2025Trial
- Auditory associative learning drives synaptic responses in tail of the striatum spiny projection neurons.iScience · 2026Article
- Article
- Article
- A claustro-cortical loop times state transitions for flexible behavior.Research square · 2026Article
- Induction of cortical on/off periods in awake mice fulfills sleep functions.Nature neuroscience · 2026Article
- Mirtazapine and Slow-Wave Sleep: A Focused Narrative Review of Human Polysomnographic Evidence.Cureus · 2026Review
- Natural Frequencies of Levodopa-Induced Dyskinesia in Parkinson's Disease.Annals of clinical and translational neurology · 2026Article
- Slow Oscillations Track Acute Stroke Injury but Not Functional Recovery.bioRxiv : the preprint server for biology · 2026Article
- A claustro-cortical loop times state transitions for flexible behavior.bioRxiv : the preprint server for biology · 2026Article
- Spatially structured heterogeneity shapes large-scale cortical dynamics in a model of the human cortex.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Whisker stimulation reinforces a resting-state network in the barrel cortex: Nested oscillations and avalanches.PLoS computational biology · 2026Article
- Predictability of sleep slow oscillation emergence and spatial extent from pre-onset neural dynamics.Scientific reports · 2026Article
- Convulsive-Like Movements in Posterior Circulation Large Vessel Occlusion: Associations With Midbrain Injury and Poor Outcome.CNS neuroscience & therapeutics · 2026Article
- Thalamic involvement defines distinct slow-wave subtypes in NREM sleep.Communications biology · 2026Article
- Classifying Sleep Slow Oscillations in Low Density EEG.Neuroinformatics · 2026Article
- State-Dependent Organization of Microscale Functional Circuitry in Visual Cortex.bioRxiv : the preprint server for biology · 2026Article
113 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
During even the most quiescent behavioral periods, the cortex and thalamus express rich spontaneous activity in the form of slow (<1 Hz), synchronous network state transitions. Throughout this so-called slow oscillation, cortical and thalamic neurons fluctuate between periods of intense synaptic activity (Up states) and almost complete silence (Down states). The two decades since the original characterization of the slow oscillation in the cortex and thalamus have seen considerable advances in deciphering the cellular and network mechanisms associated with this pervasive phenomenon. There are, nevertheless, many questions regarding the slow oscillation that await more thorough illumination, particularly the mechanisms by which Up states initiate and terminate, the functional role of the rhythmic activity cycles in unconscious or minimally conscious states, and the precise relation between Up states and the activated states associated with waking behavior. Given the substantial advances in multineuronal recording and imaging methods in both in vivo and in vitro preparations, the time is ripe to take stock of our current understanding of the slow oscillation and pave the way for future investigations of its mechanisms and functions. My aim in this Review is to provide a comprehensive account of the mechanisms and functions of the slow oscillation, and to suggest avenues for further exploration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.