Evidence map›Paper›PMID 26834552›Full record

ReviewFrontiers in neuroscience2015

Thermal Regulation of the Brain-An Anatomical and Physiological Review for Clinical Neuroscientists.

Huan Wang, Miri Kim, Kieran P Normoyle, Daniel Llano

Abstract readReview
In one paragraph

Review in Frontiers in neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Understanding the Blood-Brain Barrier: From Physiology to Pathology.Advances in experimental medicine and biology · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Differential Cutaneous Thermal Sensitivity in Humans: Method of Limit vs. Method of Sensation Magnitude.International journal of environmental research and public health · 2021
    Article
  15. Article
  16. What's in a name? That which we callMultiple sclerosis (Houndmills, Basingstoke, England) · 2021
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Huan WangDepartment of Neurosurgery, Carle Foundation HospitalUrbana, IL, USA; Thermal Neuroscience Laboratory, Beckman Institute, University of Illinois at Urbana-ChampaignUrbana, IL, USA; University of Illinois College of Medicine at Urbana-ChampaignUrbana, IL, USA.
Miri KimUniversity of Illinois College of Medicine at Urbana-ChampaignUrbana, IL, USA; Neuroscience Program and Department of Cell and Developmental Biology, University of Illinois at Urbana-ChampaignUrbana, IL, USA.
Kieran P NormoyleUniversity of Illinois College of Medicine at Urbana-ChampaignUrbana, IL, USA; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-ChampaignUrbana, IL, USA; Department of Child Neurology, Massachusetts General HospitalBoston, MA, USA.
Daniel LlanoDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-ChampaignUrbana, IL, USA; NeuroTech Group, Beckman Institute, University of Illinois at Urbana-ChampaignUrbana, IL, USA; Department of Neurology, Carle Foundation HospitalUrbana, IL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Humans, like all mammals and birds, maintain a near constant core body temperature of 36-37.5°C over a broad range of environmental conditions and are thus referred to as endotherms. The evolution of the brain and its supporting structures in mammals and birds coincided with this development of endothermy. Despite the recognition that a more evolved and complicated brain with all of its temperature-dependent cerebral circuitry and neuronal processes would require more sophisticated thermal control mechanisms, the current understanding of brain temperature regulation remains limited. To optimize the development and maintenance of the brain in health and to accelerate its healing and restoration in illness, focused, and committed efforts are much needed to advance the fundamental understanding of brain temperature. To effectively study and examine brain temperature and its regulation, we must first understand relevant anatomical and physiological properties of thermoregulation in the head-neck regions.

Indexed as

carotid retecerebral circulationcerebral thermoregulationcerebrovasculatureneuroanatomy

Identifiers

PMID26834552
PMCPMC4720747

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.