Evidence map›Paper›PMID 26834550›Full record

ArticleFrontiers in neuroscience2015

The Ever-Changing Morphology of Hippocampal Granule Neurons in Physiology and Pathology.

María Llorens-Martín, Alberto Rábano, Jesús Ávila

Abstract read
In one paragraph

Article in Frontiers in neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Article
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  4. Back to the future: improving storage of Golgi-stained mouse brain.European journal of histochemistry : EJH · 2026
    Article
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  8. Review
  9. Dynamic Organization of Neuronal Extracellular Matrix Revealed by HaloTag-HAPLN1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  10. Deoxynivalenol induces mCell biology and toxicology · 2024
    Article
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  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

María Llorens-MartínMolecular Neurobiology, Function of Microtubular Proteins, Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid)Madrid, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (Instituto de Salud Carlos III)Madrid, Spain.
Alberto RábanoCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (Instituto de Salud Carlos III)Madrid, Spain; Neuropathology Department, CIEN FoundationMadrid, Spain.
Jesús ÁvilaMolecular Neurobiology, Function of Microtubular Proteins, Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid)Madrid, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (Instituto de Salud Carlos III)Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Newborn neurons are continuously added to the hippocampal dentate gyrus throughout adulthood. In this review, we analyze the maturational stages that newborn granule neurons go through, with a focus on their unique morphological features during each stage under both physiological and pathological circumstances. In addition, the influence of deleterious (such as schizophrenia, stress, Alzheimer's disease, seizures, stroke, inflammation, dietary deficiencies, or the consumption of drugs of abuse or toxic substances) and neuroprotective (physical exercise and environmental enrichment) stimuli on the maturation of these cells will be examined. Finally, the regulation of this process by proteins involved in neurodegenerative and neurological disorders such as Glycogen synthase kinase 3β, Disrupted in Schizophrenia 1 (DISC-1), Glucocorticoid receptor, pro-inflammatory mediators, Presenilin-1, Amyloid precursor protein, Cyclin-dependent kinase 5 (CDK5), among others, will be evaluated. Given the recently acquired relevance of the dendritic branch as a functional synaptic unit required for memory storage, a full understanding of the morphological alterations observed in newborn neurons may have important consequences for the prevention and treatment of the cognitive and affective alterations that evolve in conjunction with impaired adult hippocampal neurogenesis.

Indexed as

golgihippocampusmorphologyneurodegenerationneurogenesisneuroprotectionnewborn granule neuronretrovirus

Identifiers

PMID26834550
PMCPMC4717329

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.