Evidence map›Paper›PMID 26834544›Full record

ArticleFrontiers in neuroscience2015

Tractography Activation Patterns in Dorsolateral Prefrontal Cortex Suggest Better Clinical Responses in OCD DBS.

Christian J Hartmann, J Luis Lujan, Ashutosh Chaturvedi, Wayne K Goodman, Michael S Okun, Cameron C McIntyre, Ihtsham U Haq

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In one paragraph

Article in Frontiers in neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  4. Invasive and Non-invasive Neurostimulation for OCD.Current topics in behavioral neurosciences · 2021
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  11. Prefrontal Network Mechanisms of Psychiatric Deep Brain Stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
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  15. Basal Ganglia Pathways Associated With Therapeutic Pallidal Deep Brain Stimulation for Tourette Syndrome.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Christian J HartmannDepartment of Biomedical Engineering, Cleveland Clinic FoundationCleveland, OH, USA; Department of Neurology, Medical Faculty, Institute of Clinical Neuroscience and Medical Psychology, Heinrich-Heine University DüsseldorfDüsseldorf, Germany.
J Luis LujanDepartment of Neurologic Surgery, Mayo ClinicRochester, MN, USA; Department of Physiology and Biomedical Engineering, Mayo ClinicRochester, MN, USA.
Ashutosh ChaturvediDepartment of Biomedical Engineering, Case Western Reserve University Cleveland, OH, USA.
Wayne K GoodmanDepartment of Psychiatry, Friedman Brain Institute and Mount Sinai School of Medicine New York, NY, USA.
Michael S OkunDepartment of Neurology and Neurosurgery, Center for Movement Disorders and Neurorestoration, University of Florida Gainesville, FL, USA.
Cameron C McIntyreDepartment of Biomedical Engineering, Case Western Reserve University Cleveland, OH, USA.
Ihtsham U HaqDepartment of Neurology, Wake Forest University School of Medicine Winston-Salem, NC, USA.

Funding

Tractography-Activation Models for Neuropsychiatric Deep StimulationR01MH102238 · NIMH · DUKE UNIVERSITY · PI MCINTYRE, CAMERON · 2014 to 2025
$4.5M
NIMH NIH HHS R01 MH102238
6 · The paper itself

Abstract

backgroundMedication resistant obsessive-compulsive disorder (OCD) patients can be successfully treated with Deep Brain Stimulation (DBS) which targets the anterior limb of the internal capsule (ALIC) and the nucleus accumbens (NA). Growing evidence suggests that in patients who respond to DBS, axonal fiber bundles surrounding the electrode are activated, but it is currently unknown which discrete pathways are critical for optimal benefit. Our aim was to identify axonal pathways mediating clinical effects of ALIC-NA DBS.

methodsWe created computational models of ALIC-NA DBS to simulate the activation of fiber tracts and to identify connected cerebral regions. The pattern of activated axons and their cortical targets was investigated in six OCD patients who underwent ALIC-NA DBS.

resultsModulation of the right anterior middle frontal gyrus (dorsolateral prefrontal cortex) was associated with an excellent response. In contrast, non-responders showed high activation in the orbital part of the right inferior frontal gyrus (lateral orbitofrontal cortex/anterior ventrolateral prefrontal cortex). Factor analysis followed by step-wise linear regression indicated that YBOCS improvement was inversely associated with factors that were predominantly determined by gray matter activation results. DISCUSSION: Our findings support the hypothesis that optimal therapeutic results are associated with the activation of distinct fiber pathways. This suggests that in DBS for OCD, focused stimulation of specific fiber pathways, which would allow for stimulation with lower amplitudes, may be superior to activation of a wide array of pathways, typically associated with higher stimulation amplitudes.

Indexed as

clinical efficacydeep brain stimulationobsessive-compulsive disordertractography; simulation

Identifiers

PMID26834544
PMCPMC4717315

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.